KEGG   PATHWAY: vko03440
Entry
vko03440                    Pathway                                
Name
Homologous recombination - Varanus komodoensis (Komodo dragon)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
vko03440  Homologous recombination
vko03440

Other DBs
GO: 0000724
Organism
Varanus komodoensis (Komodo dragon) [GN:vko]
Gene
123028876  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 [KO:K03111]
123035754  DNA repair protein RAD50-like isoform X1 [KO:K10866] [EC:3.6.-.-]
123029388  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
123020319  NBN; nibrin isoform X1 [KO:K10867]
123028999  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
123017394  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
123024408  BARD1; BRCA1-associated RING domain protein 1 [KO:K10683]
123020305  RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
123023423  BRIP1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
123036630  TOPBP1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
123022839  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
123033990  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
123018712  BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776]
123028305  BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
123022089  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
123034845  PALB2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
123029080  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
123028829  SYCP3; synaptonemal complex protein 3 [KO:K19528]
123023690  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
123025861  RPA2; replication protein A 32 kDa subunit [KO:K10739]
123022754  RPA3; replication protein A 14 kDa subunit [KO:K10740]
123026873  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
123016524  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
123026426  RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
123023405  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
123036744  RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
123020910  XRCC2; DNA repair protein XRCC2 [KO:K10879]
123026956  XRCC3; DNA repair protein XRCC3 [KO:K10880]
123024211  RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
123020492  RAD54B; DNA repair and recombination protein RAD54B [KO:K10877] [EC:5.6.2.-]
123030647  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
123027003  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
123017289  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
123027369  POLD4; DNA polymerase delta subunit 4 isoform X1 [KO:K03505]
123030757  BLM; Bloom syndrome protein isoform X1 [KO:K10901] [EC:5.6.2.4]
123028677  TOP3B; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
123025022  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
123032700  MUS81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
123018154  EME1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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