KEGG   PATHWAY: ypb02020
Entry
ypb02020                    Pathway                                
Name
Two-component system - Yersinia pseudotuberculosis PB1/+ (serotype 1B)
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
ypb02020  Two-component system
ypb02020

Other DBs
GO: 0000160
Organism
Yersinia pseudotuberculosis PB1/+ (serotype 1B) [GN:ypb]
Gene
YPTS_0959  PAS/PAC sensor signal transduction histidine kinase [KO:K07636] [EC:2.7.13.3]
YPTS_0958  two component transcriptional regulator, winged helix family [KO:K07657]
YPTS_2829  two component transcriptional regulator, winged helix family [KO:K07658]
YPTS_2298  Alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
YPTS_0960  phosphate binding protein [KO:K02040]
YPTS_4186  phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
YPTS_2519  integral membrane sensor signal transduction histidine kinase [KO:K07637] [EC:2.7.13.3]
YPTS_2518  two component transcriptional regulator, winged helix family [KO:K07660]
YPTS_2273  protein of unknown function DUF6 transmembrane [KO:K07790]
YPTS_3959  integral membrane sensor signal transduction histidine kinase [KO:K07638] [EC:2.7.13.3]
YPTS_3960  two component transcriptional regulator, winged helix family [KO:K07659]
YPTS_1350  porin Gram-negative type [KO:K09475]
YPTS_1537  porin Gram-negative type [KO:K09476]
YPTS_0070  integral membrane sensor signal transduction histidine kinase [KO:K07640] [EC:2.7.13.3]
YPTS_0071  two component transcriptional regulator, winged helix family [KO:K07662]
YPTS_3668  conserved hypothetical protein [KO:K25864]
YPTS_2308  integral membrane sensor signal transduction histidine kinase [KO:K07639] [EC:2.7.13.3]
YPTS_2307  two component transcriptional regulator, winged helix family [KO:K07661]
YPTS_0782  protease Do [KO:K04771] [EC:3.4.21.107]
YPTS_3301  integral membrane sensor signal transduction histidine kinase [KO:K07641] [EC:2.7.13.3]
YPTS_3302  two component transcriptional regulator, winged helix family [KO:K07663]
YPTS_2923  integral membrane sensor signal transduction histidine kinase [KO:K07642] [EC:2.7.13.3]
YPTS_2924  two component transcriptional regulator, winged helix family [KO:K07664]
YPTS_2919  efflux transporter, RND family, MFP subunit [KO:K07799]
YPTS_2920  acriflavin resistance protein [KO:K07788]
YPTS_2921  acriflavin resistance protein [KO:K07789]
YPTS_2922  major facilitator superfamily MFS_1 [KO:K18326]
YPTS_2869  transporter, hydrophobe/amphiphile efflux-1 (HAE1) family [KO:K18324]
YPTS_0498  integral membrane sensor signal transduction histidine kinase [KO:K07643] [EC:2.7.13.3]
YPTS_0499  two component transcriptional regulator, winged helix family [KO:K07771]
YPTS_2405  DegT/DnrJ/EryC1/StrS aminotransferase [KO:K07806] [EC:2.6.1.87]
YPTS_2049  heavy metal sensor signal transduction histidine kinase [KO:K07644] [EC:2.7.13.3]
YPTS_2050  two component heavy metal response transcriptional regulator, winged helix family [KO:K07665]
YPTS_2488  flagellar transcriptional activator [KO:K02403]
YPTS_2487  flagellar transcriptional activator FlhC [KO:K02402]
YPTS_3461  flagellin domain protein [KO:K02406]
YPTS_3462  flagellin domain protein [KO:K02406]
YPTS_1842  flagellin domain protein [KO:K02406]
YPTS_3455  RNA polymerase, sigma 28 subunit, FliA/WhiG [KO:K02405]
YPTS_1843  RNA polymerase, sigma 28 subunit, FliA/WhiG [KO:K02405]
YPTS_2486  chemotaxis protein MotA [KO:K02556]
YPTS_3454  MotA/TolQ/ExbB proton channel [KO:K02556]
YPTS_3034  osmosensitive K+ channel signal transduction histidine kinase [KO:K07646] [EC:2.7.13.3]
YPTS_3035  two component transcriptional regulator, winged helix family [KO:K07667]
YPTS_3031  potassium-transporting ATPase, A subunit [KO:K01546]
YPTS_3032  K+-transporting ATPase, B subunit [KO:K01547] [EC:7.2.2.6]
YPTS_3033  potassium-transporting ATPase, C subunit [KO:K01548]
YPTS_3684  multi-sensor hybrid histidine kinase [KO:K07648] [EC:2.7.13.3]
YPTS_0624  two component transcriptional regulator, winged helix family [KO:K07773]
YPTS_0001  chromosomal replication initiator protein DnaA [KO:K02313]
YPTS_0875  anaerobic c4-dicarboxylate antiporter, Dcu family [KO:K07792]
YPTS_1636  malic protein NAD-binding [KO:K00027] [EC:1.1.1.38]
YPTS_2007  integral membrane sensor signal transduction histidine kinase [KO:K07673] [EC:2.7.13.3]
YPTS_2867  two component transcriptional regulator, LuxR family [KO:K07685]
YPTS_0439  fumarate reductase, flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
YPTS_0438  succinate dehydrogenase and fumarate reductase iron-sulfur protein [KO:K00245] [EC:1.3.5.1]
YPTS_0437  fumarate reductase subunit C [KO:K00246]
YPTS_0436  fumarate reductase D subunit [KO:K00247]
YPTS_4063  phosphoglycerate transporter [KO:K07783]
YPTS_4064  integral membrane sensor signal transduction histidine kinase [KO:K07675] [EC:2.7.13.3]
YPTS_4065  two component transcriptional regulator, LuxR family [KO:K07686]
YPTS_1721  two component transcriptional regulator, LuxR family [KO:K20264]
YPTS_3096  putative lipoprotein [KO:K06080]
YPTS_1345  integral membrane sensor hybrid histidine kinase [KO:K07677] [EC:2.7.13.3]
YPTS_1347  multi-sensor signal transduction histidine kinase [KO:K07676] [EC:2.7.13.3]
YPTS_1346  two component transcriptional regulator, LuxR family [KO:K07687]
YPTS_0783  multi-sensor hybrid histidine kinase [KO:K07678] [EC:2.7.13.3]
YPTS_1867  two component transcriptional regulator, LuxR family [KO:K07689]
YPTS_0862  carbon storage regulator, CsrA [KO:K03563]
YPTS_1971  histidine kinase [KO:K07679] [EC:2.7.13.3]
YPTS_1972  two component transcriptional regulator, LuxR family [KO:K07688]
YPTS_2457  Spore coat U domain protein [KO:K27078]
YPTS_2461  Spore coat U domain protein [KO:K27078]
YPTS_2458  Spore coat U domain protein [KO:K27078]
YPTS_2456  Spore coat U domain protein [KO:K27078]
YPTS_2444  Pili assembly chaperone, N-terminal [KO:K07346]
YPTS_2459  pilus assembly chaperone [KO:K07346]
YPTS_0170  Pili assembly chaperone, N-terminal [KO:K07346]
YPTS_1431  fimbrial biogenesis outer membrane usher protein [KO:K07347]
YPTS_2446  fimbrial biogenesis outer membrane usher protein [KO:K07347]
YPTS_2460  fimbrial biogenesis outer membrane usher protein [KO:K07347]
YPTS_0169  fimbrial biogenesis outer membrane usher protein [KO:K07347]
YPTS_2765  fimbrial biogenesis outer membrane usher protein [KO:K07347]
YPTS_1968  fimbrial biogenesis outer membrane usher protein [KO:K07347]
YPTS_3509  putative membrane protein [KO:K02279]
YPTS_3510  type II and III secretion system protein [KO:K02280]
YPTS_3512  conserved hypothetical protein [KO:K02282]
YPTS_3513  type II secretion system protein E [KO:K02283] [EC:7.4.2.8]
YPTS_3514  type II secretion system protein [KO:K12510]
YPTS_3515  type II secretion system protein [KO:K12511]
YPTS_3125  UTP-GlnB uridylyltransferase, GlnD [KO:K00990] [EC:2.7.7.59]
YPTS_2981  nitrogen regulatory protein P-II [KO:K04751]
YPTS_0024  signal transduction histidine kinase, nitrogen specific, NtrB [KO:K07708] [EC:2.7.13.3]
YPTS_0023  nitrogen metabolism transcriptional regulator, NtrC, Fis Family [KO:K07712]
YPTS_0025  glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
YPTS_1284  signal transduction histidine kinase, nitrogen specific, NtrB [KO:K07709] [EC:2.7.13.3]
YPTS_1285  two component, sigma54 specific, transcriptional regulator, Fis family [KO:K07713]
YPTS_1283  conserved hypothetical protein [KO:K07803]
YPTS_4048  sodium:dicarboxylate symporter [KO:K11103]
YPTS_3712  RNA polymerase, sigma 54 subunit, RpoN [KO:K03092]
YPTS_2986  integral membrane sensor signal transduction histidine kinase [KO:K07711] [EC:2.7.13.3]
YPTS_2984  two component, sigma54 specific, transcriptional regulator, Fis family [KO:K07715]
YPTS_2478  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
YPTS_1354  methyl-accepting chemotaxis sensory transducer with Cache sensor [KO:K03406]
YPTS_2646  methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor [KO:K03406]
YPTS_2480  methyl-accepting chemotaxis sensory transducer [KO:K05874]
YPTS_3173  methyl-accepting chemotaxis sensory transducer [KO:K05874]
YPTS_4146  methyl-accepting chemotaxis sensory transducer [KO:K05875]
YPTS_2491  methyl-accepting chemotaxis sensory transducer [KO:K05876]
YPTS_2479  methyl-accepting chemotaxis sensory transducer [KO:K05877]
YPTS_2507  methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor [KO:K03776]
YPTS_2483  CheW protein [KO:K03408]
YPTS_2484  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
YPTS_2476  response regulator receiver protein [KO:K03413]
YPTS_2477  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
YPTS_0335  multi-sensor hybrid histidine kinase [KO:K14978]
YPTS_0334  two component transcriptional regulator, LuxR family [KO:K14979]
YPTS_3486  sigma54 specific transcriptional regulator, Fis family [KO:K10943]
YPTS_1162  ABC transporter related [KO:K10004] [EC:7.4.2.1]
YPTS_1163  polar amino acid ABC transporter, inner membrane subunit [KO:K10002]
YPTS_1164  polar amino acid ABC transporter, inner membrane subunit [KO:K10003]
YPTS_1165  extracellular solute-binding protein family 3 [KO:K10001]
YPTS_3921  transcriptional regulator, Crp/Fnr family [KO:K10914]
YPTS_1986  Glutaminase, core [KO:K01425] [EC:3.5.1.2]
YPTS_3355  Glutaminase, core [KO:K01425] [EC:3.5.1.2]
YPTS_1228  cytochrome bd ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
YPTS_1229  cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
YPTS_1230  cyd operon protein YbgT [KO:K00424] [EC:7.1.1.7]
YPTS_2239  type I secretion system ATPase [KO:K12530]
YPTS_2240  type I secretion membrane fusion protein, HlyD family [KO:K12532]
YPTS_2241  type I secretion system ATPase [KO:K12531]
YPTS_3541  type I secretion outer membrane protein, TolC family [KO:K12340]
YPTS_0182  UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
YPTS_0183  nucleotide sugar dehydrogenase [KO:K02472] [EC:1.1.1.336]
YPTS_0591  Pectinesterase [KO:K01051] [EC:3.1.1.11]
YPTS_3478  putative flagellar regulatory protein [KO:K02398]
YPTS_1797  anti-sigma-28 factor, FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
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Reference
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  Title
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  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
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Reference
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  Title
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  Journal
J Bacteriol 182:961-6 (2000)
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Reference
PMID:15326287
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  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
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Reference
PMID:2666399
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  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
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Reference
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  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
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  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
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Reference
PMID:15937169
  Authors
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  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
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Reference
PMID:15601704
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  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
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Reference
PMID:17448786
  Authors
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  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
PMID:19308662
  Authors
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  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
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Reference
PMID:7751278
  Authors
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  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
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Reference
PMID:10089160
  Authors
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  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
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Reference
PMID:11673427
  Authors
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  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
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Reference
PMID:11889485
  Authors
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  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
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Reference
PMID:12167640
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
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Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
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Reference
PMID:10940023
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
PMID:11807079
  Authors
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  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
DOI:10.1046/j.1365-2958.1997.4131779.x
Reference
PMID:12107138
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
DOI:10.1128/JB.184.15.4205-4210.2002
Reference
PMID:13129944
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
DOI:10.1128/JB.185.19.5735-5746.2003
Reference
PMID:12951338
  Authors
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Related
pathway
ypb00190  Oxidative phosphorylation
ypb00550  Peptidoglycan biosynthesis
ypb00910  Nitrogen metabolism
ypb02030  Bacterial chemotaxis
ypb02040  Flagellar assembly
ypb03070  Bacterial secretion system
KO pathway
ko02020   
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