KEGG   PATHWAY: zju00480
Entry
zju00480                    Pathway                                
Name
Glutathione metabolism - Ziziphus jujuba (Chinese jujube)
Class
Metabolism; Metabolism of other amino acids
Pathway map
zju00480  Glutathione metabolism
zju00480

Module
zju_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:zju00480]
Other DBs
GO: 0006749
Organism
Ziziphus jujuba (Chinese jujube) [GN:zju]
Gene
107425414  glutathione hydrolase 1 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107432786  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107432818  LOW QUALITY PROTEIN: glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107425418  glutathione hydrolase 1 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107425421  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107432767  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107432775  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107429933  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
107404632  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
107432701  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
112488868  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
107429881  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
107429880  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107429899  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107429901  LOW QUALITY PROTEIN: glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107411964  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107426924  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
107429861  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
107409956  GST; glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107405225  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
107428781  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
132800487  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
125422263  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
132800738  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132799287  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112491683  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
125422444  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
125422445  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
125422452  LOW QUALITY PROTEIN: glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
107422765  LOW QUALITY PROTEIN: probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132803120  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
125423139  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132799179  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132799202  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132803289  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107405514  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
107405516  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107405981  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107405983  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
125422179  uncharacterized protein LOC125422179 [KO:K00799] [EC:2.5.1.18]
107411172  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
107411567  probable glutathione S-transferase ParA [KO:K00799] [EC:2.5.1.18]
107411578  probable glutathione S-transferase ParA [KO:K00799] [EC:2.5.1.18]
125418778  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
132799416  probable glutathione S-transferase ParA [KO:K00799] [EC:2.5.1.18]
107430680  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107412528  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107413619  protein IN2-1 homolog B isoform X1 [KO:K00799] [EC:2.5.1.18]
107421383  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
107416184  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
107422872  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107426258  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
107426286  glutathione S-transferase PARB [KO:K00799] [EC:2.5.1.18]
107430666  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107430668  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107430677  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107430679  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107430681  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107430684  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107433279  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
107422753  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
107423369  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107428790  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
107429902  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
107419265  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107422605  glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
107426457  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
107429002  LOW QUALITY PROTEIN: glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
107423430  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107423437  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107423451  probable glutathione S-transferase ParC [KO:K00799] [EC:2.5.1.18]
107415982  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
107422694  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107413560  glutathione S-transferase DHAR1, mitochondrial isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107416296  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107422513  glutathione reductase, chloroplastic isoform X1 [KO:K00383] [EC:1.8.1.7]
107425938  glutathione reductase, chloroplastic isoform X1 [KO:K00383] [EC:1.8.1.7]
107415286  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107415806  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107424540  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107406679  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107406734  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic isoform X1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107429152  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107411652  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107433907  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107429733  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107415153  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107407004  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
107429895  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
107429896  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
107430547  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107433375  1-Cys peroxiredoxin isoform X1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
107422492  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
125418593  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
107414606  spermine synthase [KO:K00797] [EC:2.5.1.16]
107404477  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107405610  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
132803817  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
107411283  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
107424422  L-ascorbate peroxidase 3-like isoform X1 [KO:K00434] [EC:1.11.1.11]
107432898  L-ascorbate peroxidase 2, cytosolic isoform X1 [KO:K00434] [EC:1.11.1.11]
107421180  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
107425514  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
107408486  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107423228  ribonucleoside-diphosphate reductase small chain A isoform X1 [KO:K10808] [EC:1.17.4.1]
107427918  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
zju00220  Arginine biosynthesis
zju00250  Alanine, aspartate and glutamate metabolism
zju00270  Cysteine and methionine metabolism
zju00430  Taurine and hypotaurine metabolism
zju00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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