KEGG   PATHWAY: pcw00591
Entry
pcw00591                    Pathway                                
Name
Linoleic acid metabolism - Phascolarctos cinereus (koala)
Class
Metabolism; Lipid metabolism
Pathway map
pcw00591  Linoleic acid metabolism
pcw00591

Other DBs
GO: 0043651
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110192182  PROCA1; protein PROCA1 isoform X1 [KO:K01047] [EC:3.1.1.4]
110218625  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198733  calcium-dependent phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
110198734  group IIE secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110198735  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
110198736  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
110198737  basic phospholipase A2 9-like [KO:K01047] [EC:3.1.1.4]
110198738  basic phospholipase A2 RVV-VD-like [KO:K01047] [EC:3.1.1.4]
110198741  calcium-dependent phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110198750  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198758  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110197820  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
110221510  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
110222785  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198759  group IID secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110215309  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198317  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110219868  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
110223640  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110223689  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
110223735  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
110223736  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
110206877  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
110205775  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110206446  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
110195469  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
110194258  LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase-like [KO:K00460] [EC:1.13.11.33]
110213926  LOW QUALITY PROTEIN: cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
110200601  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
110215468  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110200600  cytochrome P450 2C23-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110213986  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
110192769  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110212934  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110212942  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110212976  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110212978  LOW QUALITY PROTEIN: cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110214053  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
110201906  cytochrome P450 3A24-like isoform X1 [KO:K07424] [EC:1.14.14.1]
110201914  cytochrome P450 3A4-like isoform X1 [KO:K07424] [EC:1.14.14.1]
110201917  cytochrome P450 3A9-like [KO:K07424] [EC:1.14.14.1]
110201912  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
pcw00590  Arachidonic acid metabolism
KO pathway
ko00591   
LinkDB

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