KEGG   PATHWAY: pcw00590
Entry
pcw00590                    Pathway                                
Name
Arachidonic acid metabolism - Phascolarctos cinereus (koala)
Class
Metabolism; Lipid metabolism
Pathway map
pcw00590  Arachidonic acid metabolism
pcw00590

Other DBs
GO: 0019369
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110192182  PROCA1; protein PROCA1 isoform X1 [KO:K01047] [EC:3.1.1.4]
110218625  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198733  calcium-dependent phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
110198734  group IIE secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110198735  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
110198736  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
110198737  basic phospholipase A2 9-like [KO:K01047] [EC:3.1.1.4]
110198738  basic phospholipase A2 RVV-VD-like [KO:K01047] [EC:3.1.1.4]
110198741  calcium-dependent phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110198750  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198758  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110197820  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
110221510  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
110222785  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198759  group IID secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110215309  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110198317  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110219868  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
110223640  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110223689  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
110223735  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
110223736  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
110206877  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
110205775  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110206446  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
110195469  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
110194982  prostaglandin G/H synthase 1-like [KO:K00509] [EC:1.14.99.1]
110194994  prostaglandin G/H synthase 1-like [KO:K00509] [EC:1.14.99.1]
110206875  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
110198944  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
110193776  PTGES2; prostaglandin E synthase 2 isoform X1 [KO:K05309] [EC:5.3.99.3]
110211129  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
110214881  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
110214859  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
110214882  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
110214894  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
110218298  carbonyl reductase [NADPH] 2-like isoform X1 [KO:K00081] [EC:1.1.1.184]
110200413  FAM213B; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
110215988  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
110216137  TBXAS1; thromboxane-A synthase isoform X1 [KO:K01832] [EC:5.3.99.5]
110205307  PTGDS; prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
110205092  major urinary protein 20-like [KO:K01830] [EC:5.3.99.2]
110223073  HPGDS; hematopoietic prostaglandin D synthase isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
110206638  PTGIS; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
110213916  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
110221755  LTA4H; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
110215796  ZADH2; prostaglandin reductase 3 isoform X1 [KO:K07119] [EC:1.3.1.48]
110208344  prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
110208345  prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
110208346  prostaglandin reductase 2-like isoform X1 [KO:K13949] [EC:1.3.1.48]
110208347  prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
110208348  prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
110200834  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
110216768  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
110201750  GGT5; gamma-glutamyltransferase 5 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110201755  gamma-glutamyltranspeptidase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110223406  GPX4; phospholipid hydroperoxide glutathione peroxidase, mitochondrial [KO:K05361] [EC:1.11.1.12]
110214053  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
110212934  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110212942  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110212976  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110212978  LOW QUALITY PROTEIN: cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110218598  cytochrome P450 2U1 isoform X1 [KO:K07422] [EC:1.14.14.80]
110209309  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
110209310  LOW QUALITY PROTEIN: cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
110194257  arachidonate 12-lipoxygenase, 12S-type-like isoform X1 [KO:K00458] [EC:1.13.11.31]
110194412  hydroperoxide isomerase ALOXE3-like [KO:K18684] [EC:4.2.1.152 5.4.4.7]
110194205  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
110198215  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
110198316  LOW QUALITY PROTEIN: cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
110203819  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
110204171  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
110200601  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
110215468  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110200600  cytochrome P450 2C23-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110213986  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
110192769  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110206532  EPHX2; LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
110194258  LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase-like [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
pcw00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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