KEGG   PATHWAY: pfs00362
Entry
pfs00362                    Pathway                                
Name
Benzoate degradation - Pseudomonas fluorescens SBW25
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pfs00362  Benzoate degradation
pfs00362

Module
pfs_M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:pfs00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Pseudomonas fluorescens SBW25 [GN:pfs]
Gene
PFLU_5190  Catechol 1,2-dioxygenase (EC [KO:K03381] [EC:1.13.11.1]
PFLU_5192  Muconate cycloisomerase 1 (EC [KO:K01856] [EC:5.5.1.1]
PFLU_5191  Muconolactone Delta-isomerase (MIase) (EC [KO:K03464] [EC:5.3.3.4]
PFLU_1370  Putative aromatic-hydrocarbons degradation-related hydrolase [KO:K01055] [EC:3.1.1.24]
PFLU_4532  Putative esterase [KO:K01055] [EC:3.1.1.24]
PFLU_1554  faoB; 3-ketoacyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]
PFLU_4316  Putative thiolase [KO:K00632] [EC:2.3.1.16]
PFLU_1365  pcaF; 3-oxoadipyl-CoA thiolase (EC (Beta-ketoadipyl-CoA thiolase) [KO:K07823] [EC:2.3.1.174]
PFLU_3080  Putative 2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
PFLU_1367  pcaG; Protocatechuate 3,4-dioxygenase alpha chain (EC [KO:K00448] [EC:1.13.11.3]
PFLU_1366  pcaH; Protocatechuate 3,4-dioxygenase beta chain (EC [KO:K00449] [EC:1.13.11.3]
PFLU_1369  pcaB; 3-carboxy-cis,cis-muconate cycloisomerase (EC [KO:K01857] [EC:5.5.1.2]
PFLU_1371  pcaC; 4-carboxymuconolactone decarboxylase (EC [KO:K01607] [EC:4.1.1.44]
PFLU_0857  pcaC; 4-carboxymuconolactone decarboxylase (EC [KO:K01607] [EC:4.1.1.44]
PFLU_1510  pobA; p-hydroxybenzoate hydroxylase (EC [KO:K00481] [EC:1.14.13.2]
PFLU_4912  Putative thioesterase [KO:K01075] [EC:3.1.2.23]
PFLU_4661  Putative fatty acid oxidative multifunctional enzyme [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
PFLU_1553  fadB; Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC (EC (EC; 3-hydroxyacyl-CoA dehydrogenase (EC ] [KO:K01825] [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
PFLU_0115  Putative acyl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
PFLU_3030  Putative phenylacetic acid degradation enoyl-CoA hydratase (EC [KO:K01692] [EC:4.2.1.17]
PFLU_3028  Putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PFLU_3297  Putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PFLU_3526  Putative 3-ketoacyl-CoA thiolase (EC [KO:K00626] [EC:2.3.1.9]
PFLU_0655  Putative thiolase [KO:K00626] [EC:2.3.1.9]
PFLU_4662  Putative acetyl CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PFLU_2150  Putative acetyl-CoA transferase [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
pfs00010  Glycolysis / Gluconeogenesis
pfs00020  Citrate cycle (TCA cycle)
pfs00350  Tyrosine metabolism
pfs00360  Phenylalanine metabolism
pfs00361  Chlorocyclohexane and chlorobenzene degradation
pfs00627  Aminobenzoate degradation
pfs00790  Folate biosynthesis
KO pathway
ko00362   
LinkDB

DBGET integrated database retrieval system