KEGG   PATHWAY: pphe00260
Entry
pphe00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudoalteromonas phenolica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pphe00260  Glycine, serine and threonine metabolism
pphe00260

Module
pphe_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pphe00260]
pphe_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pphe00260]
pphe_M00555  Betaine biosynthesis, choline => betaine [PATH:pphe00260]
pphe_M00621  Glycine cleavage system [PATH:pphe00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudoalteromonas phenolica [GN:pphe]
Gene
PP2015_1474  Aspartokinase [KO:K00928] [EC:2.7.2.4]
PP2015_3482  Aspartokinase [KO:K00928] [EC:2.7.2.4]
PP2015_2690  Bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
PP2015_3005  Bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
PP2015_2083  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PP2015_4222  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PP2015_2689  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
PP2015_2688  Threonine synthase [KO:K01733] [EC:4.2.3.1]
PP2015_2161  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
PP2015_2687  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PP2015_2426  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
PP2015_844  Dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PP2015_557  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PP2015_1949  Putative kinase [KO:K15918] [EC:2.7.1.31]
PP2015_2750  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PP2015_1532  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
PP2015_2483  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PP2015_716  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
PP2015_717  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
PP2015_599  Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PP2015_597  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PP2015_2473  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PP2015_598  Glycine cleavage system H protein [KO:K02437]
PP2015_1497  Phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
PP2015_1234  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PP2015_1235  Glycine betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PP2015_1252  L-serine deaminase I [KO:K01752] [EC:4.3.1.17]
PP2015_3131  Threonine deaminase [KO:K01754] [EC:4.3.1.19]
PP2015_3575  Racemase [KO:K25316] [EC:5.1.1.10]
PP2015_1862  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PP2015_1861  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pphe00010  Glycolysis / Gluconeogenesis
pphe00020  Citrate cycle (TCA cycle)
pphe00230  Purine metabolism
pphe00250  Alanine, aspartate and glutamate metabolism
pphe00270  Cysteine and methionine metabolism
pphe00290  Valine, leucine and isoleucine biosynthesis
pphe00300  Lysine biosynthesis
pphe00330  Arginine and proline metabolism
pphe00460  Cyanoamino acid metabolism
pphe00470  D-Amino acid metabolism
pphe00564  Glycerophospholipid metabolism
pphe00600  Sphingolipid metabolism
pphe00620  Pyruvate metabolism
pphe00630  Glyoxylate and dicarboxylate metabolism
pphe00640  Propanoate metabolism
pphe00680  Methane metabolism
pphe00860  Porphyrin metabolism
pphe00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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