KEGG   PATHWAY: ppq00260
Entry
ppq00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paenibacillus polymyxa SQR-21
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ppq00260  Glycine, serine and threonine metabolism
ppq00260

Module
ppq_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppq00260]
ppq_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ppq00260]
ppq_M00621  Glycine cleavage system [PATH:ppq00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paenibacillus polymyxa SQR-21 [GN:ppq]
Gene
PPSQR21_020250  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
PPSQR21_030130  aspartokinase [KO:K00928] [EC:2.7.2.4]
PPSQR21_020240  asd; strongly aspartate-semialdehyde dehydrogenase asd [KO:K00133] [EC:1.2.1.11]
PPSQR21_038950  thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PPSQR21_038940  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
PPSQR21_035960  aminoglycoside phosphotransferase [KO:K02204] [EC:2.7.1.39]
PPSQR21_036680  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PPSQR21_044300  gLY1; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PPSQR21_047170  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PPSQR21_050760  glycerate kinase [KO:K00865] [EC:2.7.1.165]
PPSQR21_023250  sixA; sixA [KO:K01834] [EC:5.4.2.11]
PPSQR21_049180  gpmA; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PPSQR21_050930  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PPSQR21_001910  gpmI; phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PPSQR21_029370  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PPSQR21_015550  serC; phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
PPSQR21_027260  had-superfamily hydrolase subfamily ia, variant 1 [KO:K25528] [EC:3.1.3.3]
PPSQR21_025300  amine oxidase [KO:K00274] [EC:1.4.3.4]
PPSQR21_037800  gcvP; glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
PPSQR21_037810  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
PPSQR21_037790  gcvT; glycine cleavage system aminomethyltransferase t [KO:K00605] [EC:2.1.2.10]
PPSQR21_006500  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PPSQR21_029800  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PPSQR21_026900  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PPSQR21_037780  gcvH; acetyl-CoA carboxylase carboxyl transferase subunit beta [KO:K02437]
PPSQR21_006760  pssA; diguanylate cyclase/phosphodiesterase with pas/pac sensor(s) [KO:K17103] [EC:2.7.8.8]
PPSQR21_045620  cdp-diacylglycerol/serine o-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PPSQR21_021960  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
PPSQR21_003930  sdaA; L-serine dehydratase, iron-sulfur-dependent subunit alpha [KO:K01752] [EC:4.3.1.17]
PPSQR21_003940  L-serine dehydratase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
PPSQR21_008550  ilvA; threonine dehydratase (threonine ammonia-lyase) [KO:K01754] [EC:4.3.1.19]
PPSQR21_028940  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PPSQR21_028950  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
PPSQR21_023550  gabT; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ppq00010  Glycolysis / Gluconeogenesis
ppq00020  Citrate cycle (TCA cycle)
ppq00230  Purine metabolism
ppq00250  Alanine, aspartate and glutamate metabolism
ppq00270  Cysteine and methionine metabolism
ppq00290  Valine, leucine and isoleucine biosynthesis
ppq00300  Lysine biosynthesis
ppq00330  Arginine and proline metabolism
ppq00460  Cyanoamino acid metabolism
ppq00470  D-Amino acid metabolism
ppq00564  Glycerophospholipid metabolism
ppq00600  Sphingolipid metabolism
ppq00620  Pyruvate metabolism
ppq00630  Glyoxylate and dicarboxylate metabolism
ppq00640  Propanoate metabolism
ppq00680  Methane metabolism
ppq00860  Porphyrin metabolism
ppq00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system