KEGG   PATHWAY: pta00260
Entry
pta00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paenibacillus terrae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pta00260  Glycine, serine and threonine metabolism
pta00260

Module
pta_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pta00260]
pta_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pta00260]
pta_M00621  Glycine cleavage system [PATH:pta00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paenibacillus terrae [GN:pta]
Gene
HPL003_18445  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
HPL003_24145  aspartokinase [KO:K00928] [EC:2.7.2.4]
HPL003_18440  aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) [KO:K00133] [EC:1.2.1.11]
HPL003_00025  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HPL003_00020  homoserine kinase [KO:K00872] [EC:2.7.1.39]
HPL003_26385  aminoglycoside phosphotransferase [KO:K02204] [EC:2.7.1.39]
HPL003_26765  threonine synthase (TS) [KO:K01733] [EC:4.2.3.1]
HPL003_03435  threonine aldolase [KO:K01620] [EC:4.1.2.48]
HPL003_04815  serine hydroxymethyltransferase (serine methylase) (SHMT) [KO:K00600] [EC:2.1.2.1]
HPL003_06910  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HPL003_26410  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HPL003_05835  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
HPL003_07995  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HPL003_08395  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
HPL003_23565  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HPL003_15740  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
HPL003_20110  HAD superfamily hydrolase [KO:K25528] [EC:3.1.3.3]
HPL003_27555  glycine dehydrogenase [decarboxylating] subunit 1 [KO:K00282] [EC:1.4.4.2]
HPL003_27560  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
HPL003_27550  glycine cleavage system aminomethyltransferase t [KO:K00605] [EC:2.1.2.10]
HPL003_20290  dihydrolipoyl dehydrogenase (E3 component of pyruvate complex) [KO:K00382] [EC:1.8.1.4]
HPL003_23830  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HPL003_16435  dihydrolipoyl dehydrogenase (E3 component of pyruvate complex) [KO:K00382] [EC:1.8.1.4]
HPL003_27545  glycine cleavage system H protein [KO:K02437]
HPL003_04035  cdp-diacylglycerol/serine o-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HPL003_10940  diguanylate cyclase/phosphodiesterase with pas/pac sensor(s) [KO:K17103] [EC:2.7.8.8]
HPL003_02090  type 11 methyltransferase [KO:K18896] [EC:2.1.1.156]
HPL003_19390  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
HPL003_02390  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
HPL003_09605  L-serine dehydratase subunit alpha [KO:K01752] [EC:4.3.1.17]
HPL003_09610  L-serine dehydratase subunit beta [KO:K01752] [EC:4.3.1.17]
HPL003_11900  threonine dehydratase biosynthetic (threonine deaminase) [KO:K01754] [EC:4.3.1.19]
HPL003_23345  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HPL003_23350  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HPL003_22390  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pta00010  Glycolysis / Gluconeogenesis
pta00020  Citrate cycle (TCA cycle)
pta00230  Purine metabolism
pta00250  Alanine, aspartate and glutamate metabolism
pta00270  Cysteine and methionine metabolism
pta00290  Valine, leucine and isoleucine biosynthesis
pta00300  Lysine biosynthesis
pta00330  Arginine and proline metabolism
pta00460  Cyanoamino acid metabolism
pta00470  D-Amino acid metabolism
pta00564  Glycerophospholipid metabolism
pta00600  Sphingolipid metabolism
pta00620  Pyruvate metabolism
pta00630  Glyoxylate and dicarboxylate metabolism
pta00640  Propanoate metabolism
pta00680  Methane metabolism
pta00860  Porphyrin metabolism
pta00920  Sulfur metabolism
KO pathway
ko00260   
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