KEGG   PATHWAY: ptex03440
Entry
ptex03440                   Pathway                                
Name
Homologous recombination - Pseudonaja textilis (eastern brown snake)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ptex03440  Homologous recombination
ptex03440

Other DBs
GO: 0000724
Organism
Pseudonaja textilis (eastern brown snake) [GN:ptex]
Gene
113451732  SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
113433730  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
113440449  MRE11; double-strand break repair protein MRE11 [KO:K10865]
113439924  NBN; nibrin isoform X1 [KO:K10867]
113449884  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
113441017  BARD1; BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
113435479  RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
113442541  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
113449319  TOPBP1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
113434880  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
113455191  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
113453437  BRISC and BRCA1-A complex member 1-like [KO:K20776]
113453438  BRISC and BRCA1-A complex member 1-like [KO:K20776]
113433193  BABAM2; BRISC and BRCA1-A complex member 2 [KO:K12173]
113437822  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
113438928  PALB2; partner and localizer of BRCA2 [KO:K10897]
113440553  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
113454605  SYCP3; synaptonemal complex protein 3 [KO:K19528]
113450011  RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
113437447  RPA2; replication protein A 32 kDa subunit [KO:K10739]
113440120  RPA3; replication protein A 14 kDa subunit [KO:K10740]
113439168  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
113434306  RAD52; DNA repair protein RAD52 homolog [KO:K10873]
113441582  RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
113442595  DNA repair protein RAD51 homolog 3-like [KO:K10870]
113441595  RAD51D; DNA repair protein RAD51 homolog 4 [KO:K10871]
113449007  XRCC2; DNA repair protein XRCC2 isoform X1 [KO:K10879]
113435032  XRCC3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
113440666  RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
113439907  RAD54B; DNA repair and recombination protein RAD54B [KO:K10877] [EC:5.6.2.-]
113442900  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
113447730  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
113453011  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
113453504  POLD4; LOW QUALITY PROTEIN: DNA polymerase delta subunit 4 [KO:K03505]
113442021  BLM; Bloom syndrome protein [KO:K10901] [EC:5.6.2.4]
113446503  TOP3B; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
113438846  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
113446654  MUS81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
113437107  EME1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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