Entry Name Synaptic vesicle cycle - Pan troglodytes (chimpanzee)
Description Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class Organismal Systems; Nervous systemBRITE hierarchy
Pathway map Other DBs Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 100610064 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X2 [KO:K03661 ]
100610704 SLC17A6; vesicular glutamate transporter 2 isoform X1 [KO:K12302 ]
100614945 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046 ]
450180 SLC1A2; excitatory amino acid transporter 2 isoform X3 [KO:K05613 ]
450939 AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824 ]
452161 SLC17A8; vesicular glutamate transporter 3 [KO:K12302 ]
452354 ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154 ]
453837 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c isoform X1 [KO:K02155 ]
454096 SLC6A2; sodium-dependent noradrenaline transporter isoform X1 [KO:K05035 ]
454587 AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825 ]
454685 ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X2 [KO:K02154 ]
455766 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3 [KO:K04344 ]
455789 SLC1A6; excitatory amino acid transporter 4 [KO:K05617 ]
455844 UNC13A; protein unc-13 homolog A isoform X4 [KO:K15293 ]
456156 AP2S1; AP-2 complex subunit sigma isoform X1 [KO:K11827 ]
456168 NAPA; alpha-soluble NSF attachment protein [KO:K15296 ]
456204 SLC17A7; vesicular glutamate transporter 1 [KO:K12302 ]
456520 SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X10 [KO:K05038 ]
458096 SNAP25; synaptosomal-associated protein 25 isoform X2 [KO:K18211 ]
458633 ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150 ]
458648 CLTCL1; clathrin heavy chain 2 isoform X11 [KO:K04646 ]
460169 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
460170 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
461918 SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614 ]
463765 ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154 ]
463832 ATP6V0E2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153 ]
464032 SLC18A1; chromaffin granule amine transporter [KO:K08155 ]
464033 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
464150 UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293 ]
464326 ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148 ]
464750 STXBP1; syntaxin-binding protein 1 isoform X2 [KO:K15292 ]
464893 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
464974 SLC1A1; excitatory amino acid transporter 3 isoform X1 [KO:K05612 ]
466071 SLC18A3; vesicular acetylcholine transporter [KO:K14636 ]
466213 SLC18A2; synaptic vesicular amine transporter [KO:K08155 ]
466470 SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038 ]
466895 TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X2 [KO:K02154 ]
467192 SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045 ]
468201 SLC6A4; sodium-dependent serotonin transporter isoform X2 [KO:K05037 ]
468956 AP2A1; AP-2 complex subunit alpha-1 isoform X2 [KO:K11824 ]
469329 SLC1A7; excitatory amino acid transporter 5 isoform X2 [KO:K05618 ]
469629 ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152 ]
469940 SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015 ]
470401 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
471694 SLC6A7; sodium-dependent proline transporter isoform X2 [KO:K05040 ]
472054 RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X3 [KO:K15291 ]
472809 ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146 ]
473030 ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152 ]
740229 ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144 ]
740323 ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153 ]
741872 ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146 ]
744244 ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152 ]
744772 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148 ]
747237 VAMP2; vesicle-associated membrane protein 2 isoform X2 [KO:K13504 ]
750842 SLC6A3; sodium-dependent dopamine transporter isoform X1 [KO:K05036 ]
Compound Reference Authors Li L, Chin LS
Title The molecular machinery of synaptic vesicle exocytosis.
Journal Reference Authors Nestler EJ, Hyman SE, Malenka RC.
Title Molecular neuropharmacology: A foundation for clinical neuroscience
Journal The McGraw-Hill Companies, Inc. (2001)
Reference Authors Chapman ER
Title How does synaptotagmin trigger neurotransmitter release?
Journal Reference Authors Benfenati F, Onofri F, Giovedi S
Title Protein-protein interactions and protein modules in the control of neurotransmitter release.
Journal Reference Authors de Saint Basile G, Menasche G, Fischer A
Title Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
Journal Reference Authors Carr CM, Munson M
Title Tag team action at the synapse.
Journal Reference Authors Sudhof TC
Title The synaptic vesicle cycle.
Journal Reference Authors Gundelfinger ED, Kessels MM, Qualmann B
Title Temporal and spatial coordination of exocytosis and endocytosis.
Journal Reference Authors Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
Title A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Journal Reference Authors Chapman ER
Title Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
Journal Reference Authors Sudhof TC
Title The synaptic vesicle cycle: a cascade of protein-protein interactions.
Journal Reference Authors Rizo J, Sudhof TC
Title Snares and Munc18 in synaptic vesicle fusion.
Journal Reference Authors Malsam J, Kreye S, Sollner TH
Title Membrane fusion: SNAREs and regulation.
Journal Related KO pathway
