KEGG PATHWAY: rme00790

PATHWAY: rme00790

Entry

rme00790                    Pathway

Name

Folate biosynthesis - Cupriavidus metallidurans

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

rme00790

Folate biosynthesis

Module

rme_M00126

Tetrahydrofolate biosynthesis, GTP => THF [PATH:rme00790]

rme_M00880

Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:rme00790]

rme_M00988

PreQ1 biosynthesis, GTP => 7-Aminomethyl-7-deazaguanine [PATH:rme00790]

Other DBs

GO:

0046656

Organism

Cupriavidus metallidurans [GN:rme]

Gene

Rmet_0183

folB; dihydroneopterin aldolase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]

Rmet_0194

ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]

Rmet_0353

queF; NADPH-dependent 7-cyano-7-deazaguanine reductase (NADPH-dependent nitrile oxidoreductase) [KO:K06879] [EC:1.7.1.13]

Rmet_0358

[KO:K07141] [EC:2.7.7.76]

Rmet_0380

ntpA; dATP pyrophosphohydrolase protein [KO:K08310] [EC:3.6.1.67]

Rmet_0486

moaC; molybdopterin biosynthesis, protein C [KO:K03637] [EC:4.6.1.17]

Rmet_1099

[KO:K09007] [EC:3.5.4.16]

Rmet_1101

[KO:K01737] [EC:4.2.3.12 4.1.2.50]

Rmet_1571

[KO:K10026] [EC:4.3.99.3]

Rmet_1572

ptpS; 6-Pyruvoyl tetrahydrobiopterin synthase protein [KO:K01737] [EC:4.2.3.12 4.1.2.50]

Rmet_1962

moaE; molybdopterin synthase, large subunit [KO:K03635] [EC:2.8.1.12]

Rmet_1964

moeA; molybdopterin biosynthesis protein (MoeA-like, domain I and II) [KO:K03750] [EC:2.10.1.1]

Rmet_2187

folP; 7,8-dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]

Rmet_2441

moaA; molybdopterin biosynthesis protein A [KO:K03639] [EC:4.1.99.22]

Rmet_2442

mobA; Molybdopterin-guanine dinucleotide biosynthesis protein A [KO:K03752] [EC:2.7.7.77]

Rmet_2443

moeA; molybdopterin biosynthesis protein [KO:K03750] [EC:2.10.1.1]

Rmet_2463

folC; bifunctional folylpolyglutamate synthase and dihydrofolate synthase [KO:K11754] [EC:6.3.2.12 6.3.2.17]

Rmet_2569

folA; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]

Rmet_2572

mogA; molybdochelatase MogA, involved in Moco biosynthesis [KO:K03831] [EC:2.7.7.75]

Rmet_2583

phoD; Phosphodiesterase/alkaline phosphatase D [KO:K01113] [EC:3.1.3.1]

Rmet_2613

[KO:K01113] [EC:3.1.3.1]

Rmet_2614

[KO:K09007] [EC:3.5.4.16]

Rmet_2672

queC; Queuosine biosynthesis protein queC [KO:K06920] [EC:6.3.4.20]

Rmet_2693

ribBA; bifunctional riboflavin biosynthesis protein RibBA: 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II [KO:K14652] [EC:4.1.99.12 3.5.4.25]

Rmet_2915

folK; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]

Rmet_2920

pabB; Anthranilate/para-aminobenzoate synthase component I [KO:K03342] [EC:2.6.1.85 4.1.3.38]

Rmet_3533

phhA; phenylalanine-4-hydroxylase (PAH) (Phe-4-monooxygenase) [KO:K00500] [EC:1.14.16.1]

Rmet_3534

phhB; pterin-4-alpha-carbinolamine dehydratase (transcriptional co-activator) [KO:K01724] [EC:4.2.1.96]

Rmet_3990

folE; GTP cyclohydrolase I [KO:K01495] [EC:3.5.4.16]

Rmet_4084

phoA1; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

Rmet_4085

phoA2; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

Compound

C00044

GTP

C00101

Tetrahydrofolate

C00119

5-Phospho-alpha-D-ribose 1-diphosphate

C00156

4-Hydroxybenzoate

C00251

Chorismate

C00266

Glycolaldehyde

C00268

Dihydrobiopterin

C00272

Tetrahydrobiopterin

C00415

Dihydrofolate

C00504

Folate

C00568

4-Aminobenzoate

C00835

Sepiapterin

C00921

Dihydropteroate

C01217

5,6,7,8-Tetrahydromethanopterin

C01300

6-(Hydroxymethyl)-7,8-dihydropterin

C01304

2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

C02587

Pyrimidodiazepine

C02953

7,8-Dihydrobiopterin

C03541

THF-polyglutamate

C03684

6-Pyruvoyltetrahydropterin

C04244

6-Lactoyl-5,6,7,8-tetrahydropterin

C04807

6-Hydroxymethyl-7,8-dihydropterin diphosphate

C04874

7,8-Dihydroneopterin

C04895

7,8-Dihydroneopterin 3'-triphosphate

C05922

Formamidopyrimidine nucleoside triphosphate

C05923

2,5-Diaminopyrimidine nucleoside triphosphate

C05924

Molybdopterin

C05925

Dihydroneopterin phosphate

C05926

Neopterin

C05927

7,8-Dihydromethanopterin

C06148

2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

C06313

Biopterin

C09332

THF-L-glutamate

C11355

4-Amino-4-deoxychorismate

C15522

4a-Hydroxytetrahydrobiopterin

C15996

7-Cyano-7-carbaguanine

C16675

7-Aminomethyl-7-carbaguanine

C18237

Molybdoenzyme molybdenum cofactor

C18239

Precursor Z

C18802

Tetrahydrosarcinapterin

C19848

Adenylated molybdopterin

C19871

Guanylyl molybdenum cofactor

C20239

6-Carboxy-5,6,7,8-tetrahydropterin

C20248

7-Carboxy-7-carbaguanine

C20264

L-threo-Tetrahydrobiopterin

C20559

4-(beta-D-Ribofuranosyl)aniline 5'-phosphate

C20562

N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate

C20566

7,8-Dihydroneopterin 2'-phosphate

C20567

7,8-Dihydroneopterin 2',3'-cyclic phosphate

C21007

5,6,7,8-Tetrahydromonapterin

C21008

7,8-Dihydromonapterin

C21065

7,8-Dihydroxanthopterin

C21094

7,8-Dihydromonapterin 3'-triphosphate

C21107

4-(beta-D-Ribofuranosyl)phenol 5'-phosphate

C21310

(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate

C21485

Cytidylyl molybdenum cofactor

C21486

Thio-molybdenum cofactor

C21640

6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19675644

Authors

Schwarz G, Mendel RR, Ribbe MW

Title

Molybdenum cofactors, enzymes and pathways.

Journal

Nature 460:839-47 (2009)
DOI:10.1038/nature08302

Reference

PMID:16632608

Authors

Hanzelmann P, Schindelin H

Title

Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.

Journal

Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103

Reference

PMID:18092812

Authors

Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H

Title

Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.

Journal

Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g

Reference

PMID:12571226

Authors

Wuebbens MM, Rajagopalan KV

Title

Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.

Journal

J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200

Reference

PMID:21867484