KEGG   PATHWAY: rme00230
Entry
rme00230                    Pathway                                
Name
Purine metabolism - Cupriavidus metallidurans
Class
Metabolism; Nucleotide metabolism
Pathway map
rme00230  Purine metabolism
rme00230

Module
rme_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:rme00230]
rme_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:rme00230]
rme_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:rme00230]
rme_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:rme00230]
rme_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:rme00230]
rme_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:rme00230]
rme_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:rme00230]
Other DBs
GO: 0006163 0042278
Organism
Cupriavidus metallidurans [GN:rme]
Gene
Rmet_0289  prs; Ribose-phosphate pyrophosphokinase (RPPK) (Phosphoribosyl pyrophosphate synthetase) (P-Rib-PP synthetase) (PRPP synthetase) [KO:K00948] [EC:2.7.6.1]
Rmet_0311  apt; adenine phosphoribosyltransferase (APRT) [KO:K00759] [EC:2.4.2.7]
Rmet_0427  purH; fused IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Rmet_0504  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) [KO:K01923] [EC:6.3.2.6]
Rmet_0505  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
Rmet_0506  purK; Phosphoribosylaminoimidazole carboxylase ATPase subunit (AIR carboxylase) (AIRC) [KO:K01589] [EC:6.3.4.18]
Rmet_0532  adk; adenylate kinase (ATP-AMP transphosphorylase) [KO:K00939] [EC:2.7.4.3]
Rmet_0572  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
Rmet_0784  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
Rmet_0851  yggV; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
Rmet_0856  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
Rmet_0858  spoT; bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Rmet_0881  [KO:K13485] [EC:4.1.1.97]
Rmet_0882  [KO:K16842] [EC:3.5.2.5]
Rmet_0885  [KO:K07127] [EC:3.5.2.17]
Rmet_0889  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
Rmet_0890  add; adenosine deaminase [KO:K21053] [EC:3.5.4.2]
Rmet_0892  xdhB; xanthine dehydrogenase, subunit B [KO:K13482] [EC:1.17.1.4]
Rmet_0893  xdhA; xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [KO:K13481] [EC:1.17.1.4]
Rmet_0942  [KO:K01515] [EC:3.6.1.13 3.6.1.-]
Rmet_0958  ureA; Urea amidohydrolase (urease) gamma subunit [KO:K01430] [EC:3.5.1.5]
Rmet_0960  ureB; Urea amidohydrolase (urease) beta subunit [KO:K01429] [EC:3.5.1.5]
Rmet_0961  ureC; Urea amidohydrolase (urease) alpha subunit [KO:K01428] [EC:3.5.1.5]
Rmet_1159  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
Rmet_1354  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
Rmet_1461  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
Rmet_1463  guaA; GMP synthetase (glutamine aminotransferase) [KO:K01951] [EC:6.3.5.2]
Rmet_1579  [KO:K01951] [EC:6.3.5.2]
Rmet_1820  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
Rmet_1870  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
Rmet_1945  [KO:K02083] [EC:3.5.3.9]
Rmet_2096  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Rmet_2110  ndk; multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
Rmet_2118  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
Rmet_2130  nrdJ; ribonucleotide reductase, coenzyme B12-dependent [KO:K00525] [EC:1.17.4.1]
Rmet_2177  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Rmet_2460  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
Rmet_2716  cpsG; phosphomannomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
Rmet_2736  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
Rmet_2812  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
Rmet_2813  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
Rmet_2878  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
Rmet_2901  [KO:K09913] [EC:2.4.2.1 2.4.2.2]
Rmet_2911  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
Rmet_2956  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
Rmet_3069  [KO:K00856] [EC:2.7.1.20]
Rmet_3087  nrdB; Ribonucleoside-diphosphate reductase beta subunit [KO:K00526] [EC:1.17.4.1]
Rmet_3088  nrdA; Ribonucleoside-diphosphate reductase alpha subunit [KO:K00525] [EC:1.17.4.1]
Rmet_3095  hpt; Hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Rmet_3265  dgt; dGTP Triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
Rmet_3443  [KO:K02083] [EC:3.5.3.9]
Rmet_3722  [KO:K01487] [EC:3.5.4.3]
Rmet_3885  [KO:K16841] [EC:5.1.99.3]
Rmet_4019  surE; 5'-nucleotidase; stationary-phase survival protein; protein damage control [KO:K03787] [EC:3.1.3.5 3.1.3.6]
Rmet_4844  [KO:K03651] [EC:3.1.4.53]
Rmet_5139  nrdD; anaerobic ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
Rmet_5885  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
rme00030  Pentose phosphate pathway
rme00220  Arginine biosynthesis
rme00250  Alanine, aspartate and glutamate metabolism
rme00260  Glycine, serine and threonine metabolism
rme00340  Histidine metabolism
rme00630  Glyoxylate and dicarboxylate metabolism
rme00730  Thiamine metabolism
rme00740  Riboflavin metabolism
rme00790  Folate biosynthesis
KO pathway
ko00230   

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