Entry |
|
Name |
Valine, leucine and isoleucine biosynthesis |
Class |
Metabolism; Amino acid metabolism
|
Pathway map |
rn00290 | Valine, leucine and isoleucine biosynthesis |

|
Module |
M00019 | Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:rn00290] |
M00432 | Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:rn00290] |
M00535 | Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:rn00290] |
M00570 | Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:rn00290] |
|
Other DBs |
|
Reaction |
R00226 | pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating) |
R00994 | (2R,3S)-3-methylmalate:NAD+ oxidoreductase |
R00996 | L-threonine ammonia-lyase (2-oxobutanoate-forming) |
R01088 | L-leucine:NAD+ oxidoreductase (deaminating) |
R01090 | L-leucine:2-oxoglutarate aminotransferase |
R01213 | acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) |
R01214 | L-valine:2-oxoglutarate aminotransferase |
R01215 | L-valine:pyruvate aminotransferase |
R01434 | L-valine:NAD+ oxidoreductase(deaminating) |
R02196 | L-isoleucine:NAD+ oxidoreductase(deaminating) |
R02199 | L-isoleucine:2-oxoglutarate aminotransferase |
R03896 | (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming) |
R03898 | 2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming) |
R03968 | 2-isopropylmalate hydro-lyase |
R04001 | 3-isopropylmalate hydro-lyase |
R04426 | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase |
R04440 | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) |
R04441 | (R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase |
R05068 | (R)-2,3-dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing) |
R05069 | (S)-2-aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing) |
R05070 | (R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase |
R05071 | (S)-2-acetolactate methylmutase |
R08648 | pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating) |
|
Compound |
C00141 | 3-Methyl-2-oxobutanoic acid |
C00233 | 4-Methyl-2-oxopentanoate |
C00671 | (S)-3-Methyl-2-oxopentanoic acid |
C04181 | 3-Hydroxy-3-methyl-2-oxobutanoic acid |
C04236 | (2S)-2-Isopropyl-3-oxosuccinate |
C04272 | (R)-2,3-Dihydroxy-3-methylbutanoate |
C04411 | (2R,3S)-3-Isopropylmalate |
C06006 | (S)-2-Aceto-2-hydroxybutanoate |
C06007 | (R)-2,3-Dihydroxy-3-methylpentanoate |
C06032 | D-erythro-3-Methylmalate |
C14463 | (R)-3-Hydroxy-3-methyl-2-oxopentanoate |
|
Reference |
|
Authors |
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G. |
Title |
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. |
Journal |
|
Related pathway |
rn00260 | Glycine, serine and threonine metabolism |
rn00280 | Valine, leucine and isoleucine degradation |
|
KO pathway |
|