KEGG   PATHWAY: rn00290
Entry
rn00290                     Pathway                                

Name
Valine, leucine and isoleucine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
rn00290  Valine, leucine and isoleucine biosynthesis
rn00290

Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:rn00290]
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:rn00290]
M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:rn00290]
M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:rn00290]
Other DBs
GO: 0009097 0009098 0009099
Reaction
R00226  pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
R00994  (2R,3S)-3-methylmalate:NAD+ oxidoreductase
R00996  L-threonine ammonia-lyase (2-oxobutanoate-forming)
R01088  L-leucine:NAD+ oxidoreductase (deaminating)
R01090  L-Leucine:2-oxoglutarate aminotransferase
R01213  acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
R01214  L-Valine:2-oxoglutarate aminotransferase
R01215  L-Valine:pyruvate aminotransferase
R01434  L-valine:NAD+ oxidoreductase(deaminating)
R01652   
R02196  L-Isoleucine:NAD+ oxidoreductase(deaminating)
R02199  L-Isoleucine:2-oxoglutarate aminotransferase
R03896  (R)-2-Methylmalate hydro-lyase (2-methylmaleate-forming)
R03898  2-methylmaleate hydratase
R03968  2-Isopropylmalate hydro-lyase
R04001  3-Isopropylmalate hydro-lyase
R04426  (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
R04440  (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
R04441  (R)-2,3-Dihydroxy-3-methylbutanoate hydro-lyase
R05068  (R)-2,3-Dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing)
R05069  (S)-2-Aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing)
R05070  (R)-2,3-Dihydroxy-3-methylpentanoate hydro-lyase
R05071  (S)-2-Acetolactate methylmutase
R07399   
R08648  pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
rn00260  Glycine, serine and threonine metabolism
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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