KEGG   PATHWAY: rn00290
Entry
rn00290                     Pathway                                
Name
Valine, leucine and isoleucine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
rn00290  Valine, leucine and isoleucine biosynthesis
rn00290

Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:rn00290]
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:rn00290]
M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:rn00290]
M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:rn00290]
Other DBs
GO: 0009097 0009098 0009099
Reaction
R00226  pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
R00994  (2R,3S)-3-methylmalate:NAD+ oxidoreductase
R00996  L-threonine ammonia-lyase (2-oxobutanoate-forming)
R01088  L-leucine:NAD+ oxidoreductase (deaminating)
R01090  L-leucine:2-oxoglutarate aminotransferase
R01213  acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
R01214  L-valine:2-oxoglutarate aminotransferase
R01215  L-valine:pyruvate aminotransferase
R01434  L-valine:NAD+ oxidoreductase(deaminating)
R01652  
R02196  L-isoleucine:NAD+ oxidoreductase(deaminating)
R02199  L-isoleucine:2-oxoglutarate aminotransferase
R03896  (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
R03898  2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
R03968  2-isopropylmalate hydro-lyase
R04001  3-isopropylmalate hydro-lyase
R04426  (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
R04440  (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
R04441  (R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
R05068  (R)-2,3-dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing)
R05069  (S)-2-aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing)
R05070  (R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
R05071  (S)-2-acetolactate methylmutase
R07399  
R08648  pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
rn00260  Glycine, serine and threonine metabolism
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
KO pathway
ko00290   

DBGET integrated database retrieval system