PATHWAY: rn00280 Help Entry rn00280                     Pathway                                 Name Valine, leucine and isoleucine degradation Class Metabolism; Amino acid metabolism Pathway map rn00280   Valine, leucine and isoleucine degradation Module M00036   Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:rn00280] M00741   Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:rn00280] Other DBs GO:  0006550 0006552 0006574 Reaction R00238   acetyl-CoA:acetyl-CoA C-acetyltransferase R00410   succinyl-CoA:acetoacetate CoA-transferase R00833   (R)-methylmalonyl-CoA CoA-carbonylmutase R00922   2-methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating) R00927   acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase; 2-methylacetoacetyl-CoA thiolase R01088   L-leucine:NAD+ oxidoreductase (deaminating) R01090   L-leucine:2-oxoglutarate aminotransferase R01214   L-valine:2-oxoglutarate aminotransferase R01357   acetoacetate:CoA ligase (AMP-forming) R01360   (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) R01434   L-valine:NAD+ oxidoreductase(deaminating) R01859   propanoyl-CoA:carbon-dioxide ligase (ADP-forming) R01978   acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) R02050   (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase R02085   (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming) R02197   L-isoleucine:oxygen oxidoreductase (deaminating) R02199   L-isoleucine:2-oxoglutarate aminotransferase R02661   2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase R02662   2-methylpropanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase R02663   R02764   (S)-methylmalonyl-CoA hydrolase R02765   methylmalonyl-CoA epimerase R03172   (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase R03174   (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase R03175   R03383   methylmalonate:CoA ligase (AMP-forming) R03869   (S)-methylmalonate semialdehyde:NAD+ oxidoreductase R03871   (S)-methylmalonate semialdehyde:oxygen oxidoreductase R04095   3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase R04097   3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase R04098   R04137   3-hydroxyisovaleryl-CoA hydro-lyase R04138   3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) R04187   L-alanine:3-oxopropanoate aminotransferase R04188   L-3-amino-isobutanoate:2-oxoglutarate aminotransferase R04203   (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase R04204   (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase R04224   (S)-3-hydroxyisobutyryl-CoA hydro-lyase R05064   (S)-3-hydroxyisobutyryl-CoA hydrolase R05066   3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase R07160   3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating) R07599   R07600   R07601   R07602   R07603   R07604   R07618   enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase R08566   4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating) R08567   (S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating) R10759   Compound C00024   Acetyl-CoA C00068   Thiamin diphosphate C00091   Succinyl-CoA C00100   Propanoyl-CoA C00123   L-Leucine C00141   3-Methyl-2-oxobutanoic acid C00164   Acetoacetate C00183   L-Valine C00233   4-Methyl-2-oxopentanoate C00332   Acetoacetyl-CoA C00349   2-Methyl-3-oxopropanoate C00356   (S)-3-Hydroxy-3-methylglutaryl-CoA C00407   L-Isoleucine C00630   2-Methylpropanoyl-CoA C00671   (S)-3-Methyl-2-oxopentanoic acid C00683   (S)-Methylmalonyl-CoA C01205   (R)-3-Amino-2-methylpropanoate C01213   (R)-Methylmalonyl-CoA C02170   Methylmalonate C02939   3-Methylbutanoyl-CoA C03069   3-Methylcrotonyl-CoA C03231   3-Methylglutaconyl-CoA C03284   L-3-Aminoisobutanoate C03344   2-Methylacetoacetyl-CoA C03345   2-Methylbut-2-enoyl-CoA C03460   2-Methylprop-2-enoyl-CoA C04405   (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA C05996   Branched chain fatty acid C05998   3-Hydroxyisovaleryl-CoA C06000   (S)-3-Hydroxyisobutyryl-CoA C06001   (S)-3-Hydroxyisobutyrate C06002   (S)-Methylmalonate semialdehyde C15972   Enzyme N6-(lipoyl)lysine C15973   Enzyme N6-(dihydrolipoyl)lysine C15974   3-Methyl-1-hydroxybutyl-ThPP C15975   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine C15976   2-Methyl-1-hydroxypropyl-ThPP C15977   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine C15978   2-Methyl-1-hydroxybutyl-ThPP C15979   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine C15980   (S)-2-Methylbutanoyl-CoA C20827   3-Hydroxyisovalerate Related pathway rn00020   Citrate cycle (TCA cycle) rn00240   Pyrimidine metabolism rn00290   Valine, leucine and isoleucine biosynthesis rn00522   Biosynthesis of 12-, 14- and 16-membered macrolides rn00640   Propanoate metabolism rn00900   Terpenoid backbone biosynthesis rn01056   Biosynthesis of type II polyketide backbone KO pathway ko00280

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