KEGG   PATHWAY: rn00310
Entry
rn00310                     Pathway                                
Name
Lysine degradation
Class
Metabolism; Amino acid metabolism
Pathway map
rn00310  Lysine degradation
rn00310

Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:rn00310]
M00956  Lysine degradation, bacteria, L-lysine => succinate [PATH:rn00310]
M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA [PATH:rn00310]
M00960  Lysine degradation, bacteria, L-lysine => D-lysine => succinate [PATH:rn00310]
Other DBs
GO: 0006554
Reaction
R00238  acetyl-CoA:acetyl-CoA C-acetyltransferase
R00447  L-lysine:oxygen 2-oxidoreductase (deaminating)
R00449  L-lysine:oxygen 2-oxidoreductase (decarboxylating)
R00452  N2-(D-1-carboxylethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
R00454  acetyl-CoA:L-lysine N6-acetyltransferase
R00458  N6-acetyl-L-lysine amidohydrolase
R00460  lysine racemase
R00461  L-lysine 2,3-aminomutase
R00462  L-lysine carboxy-lyase (cadaverine-forming)
R00715  N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
R00716  N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
R01171  butanoyl-CoA:NAD+ trans-2-oxidoreductase
R01365  butanoyl-CoA:acetoacetate CoA-transferase
R01620  acetyl-phosphate:L-lysine N6-acetyltransferase
R01939  L-2-aminoadipate:2-oxoglutarate aminotransferase
R01975  (S)-3-hydroxybutanoyl-CoA:NAD+ oxidoreductase
R02201  L-pipecolate:NAD+ 2-oxidoreductase
R02203  L-pipecolate:NADP+ 2-oxidoreductase
R02204  L-pipecolate:oxygen 1,6-oxidoreductase
R02205  L-pipecolate:(acceptor) 1,6-oxidoreductase
R02273  5-aminopentanamide amidohydrolase
R02274  5-aminopentanoate:2-oxoglutarate aminotransferase
R02276  5-acetamidopentanoate amidohydrolase
R02313  N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
R02315  N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
R02317  (S)-2-amino-6-oxohexanoate hydro-lyase (spontaneous)
R02397  4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
R02401  glutarate-semialdehyde:NAD+ oxidoreductase
R02402  glutarate:CoA ligase (ADP-forming)
R02488  glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
R02571  glutaryl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-glutaryltransferase
R02851  D-lysine:2-oxocarboxylate aminotransferase
R02852  D-2,6-diaminohexanoic acid 5,6-aminomutase
R03026  (S)-3-hydroxybutanoyl-CoA hydro-lyase
R03030  L-3-aminobutyryl-CoA ammonia-lyase
R03102  L-2-aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase
R03103  L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
R03275  (3S)-3,6-diaminohexanoate 5,6-aminomutase
R03283  4-trimethylammoniobutanal:NAD+ 1-oxidoreductase; 4-trimethylammoniobutanal:NAD+ oxidoreductase
R03284  
R03349  L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)
R03376  [procollagen]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
R03378  GTP:5-hydroxy-L-lysine O-phosphotransferase
R03380  UDP-alpha-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
R03451  N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
R03875  
R04029  N6-acetyl-L-lysine:2-oxoglutarate aminotransferase
R04142  
R04174  6-acetamido-2-oxohexanoate amidohydrolase
R04175  
R04313  
R04687  2,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)
R04688  2,5-diaminohexanoate:NADP+ oxidoreductase (deaminating)
R04866  S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase
R04867  S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase
R07618  enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
R08414  
R09738  butanoyl-CoA:NADP+ 2,3-oxidoreductase
R10270  (5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
R10564  (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase
R12214  cadaverine:2-oxoglutarate aminotransferase
R12215  5-aminopentanal:NAD+ 1-oxidoreductase
R12216  glutarate,2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)
R12217  (S)-2-hydroxyglutarate:quinone oxidoreductase
R12305  D-lysine carboxy-lyase
R13011  2-oxoadipate dioxygenase/carboxy lyase
R13034  
R13035  
R13036  
R13037  
R13166  
R13167  
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
rn00020  Citrate cycle (TCA cycle)
rn00300  Lysine biosynthesis
rn00311  Penicillin and cephalosporin biosynthesis
rn00780  Biotin metabolism
KO pathway
ko00310   

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