KEGG   PATHWAY: ko00310
Entry
ko00310                     Pathway                                
Name
Lysine degradation
Class
Metabolism; Amino acid metabolism
Pathway map
ko00310  Lysine degradation
ko00310

Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ko00310]
M00956  Lysine degradation, bacteria, L-lysine => succinate [PATH:ko00310]
M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA [PATH:ko00310]
M00960  Lysine degradation, bacteria, L-lysine => D-lysine => succinate [PATH:ko00310]
Other DBs
GO: 0006554
Orthology
K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00128  ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K00135  gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
K00137  prr; aminobutyraldehyde dehydrogenase [EC:1.2.1.19]
K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00252  GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
K00306  PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]
K00382  DLD, lpd, pdhD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00468  davB; lysine 2-monooxygenase
K00471  BBOX1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
K00473  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
K00474  TMLHE; trimethyllysine dioxygenase [EC:1.14.11.8]
K00626  ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00658  DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K00824  dat; D-alanine transaminase [EC:2.6.1.21]
K00825  AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
K01034  atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
K01035  atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
K01041  gcdG, caiB; glutaryl-CoA transferase
K01506  davA; 5-aminopentanamidase
K01582  E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18]
K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
K01782  fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K01843  kamA; lysine 2,3-aminomutase [EC:5.4.3.2]
K01844  kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]
K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]
K07250  gabT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]
K07511  ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]
K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]
K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]
K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]
K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]
K09251  patA; putrescine aminotransferase [EC:2.6.1.82]
K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]
K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]
K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K11424  WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357]
K11425  WHSC1L1, NSD3; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371]
K11426  SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357]
K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
K11428  SETD8; [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361]
K11429  SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362]
K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
K11431  SETD7; [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364]
K11432  PRDM2, RIZ; [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355]
K11433  SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357]
K11703  GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
K13609  dpkA, lhpD; delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
K13645  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
K13646  PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]
K13647  PLODN; procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
K14085  ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K14157  AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]
K14268  davT, gabT; 5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19]
K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
K15588  NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357]
K15736  lhgO; (S)-2-hydroxyglutarate dehydrogenase [EC:1.1.5.13]
K15737  csiD; glutarate dioxygenase [EC:1.14.11.64]
K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]
K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
K18011  kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]
K18012  kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]
K18013  kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]
K18014  kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]
K18201  AGPHD1; hydroxylysine kinase [EC:2.7.1.81]
K18202  AGXT2L2; 5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134]
K18494  SETDB2; [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355]
K18804  CTM1; [cytochrome c]-lysine N-methyltransferase [EC:2.1.1.59]
K18826  CAMKMT; calmodulin-lysine N-methyltransferase [EC:2.1.1.60]
K18854  LYC1; acetyl-CoA:lysine N6-acetyltransferase [EC:2.3.1.306]
K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
K20795  PRDM6; [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361]
K20796  PRDM7_9; [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]
K21672  ord; 2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
K22410  PRDM16; [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367]
K22748  ATXR3, SDG2; [histone H3]-lysine4 N-trimethyltransferase ATXR3 [EC:2.1.1.354]
K23385  dokD; D-ornithine/D-lysine decarboxylase
K23700  SET2; [histone H3]-lysine36 N-trimethyltransferase
K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
K24405  SUVH1; [histone H3]-lysine9 N-dimethyltransferase
K24406  ATXR5_6; [histone H3]-lysine27 N-methyltransferase
K24407  SET9; [histone H4]-lysine20 N-trimethyltransferase
K25316  racX, ygeA; amino-acid racemase
K25317  alr, bsrV; amino-acid racemase
K25986  ydcJ; 2-oxoadipate dioxygenase/decarboxylase
K26061  amaB; L-aminoadipate-semialdehyde dehydrogenase
K26062  K26062; 2-aminoadipate transaminase
K26063  ydiJ; (R)-2-hydroxyglutarate dehydrogenase
K26064  amaD; D-lysine oxidase
K26065  amaA; L-pipecolate oxidase
K28522  HGLS; 2-oxoadipate dioxygenase/decarboxylase
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00300  Lysine biosynthesis
ko00311  Penicillin and cephalosporin biosynthesis
ko00780  Biotin metabolism

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