KEGG PATHWAY: spo00564

PATHWAY: spo00564

Entry

spo00564                    Pathway

Name

Glycerophospholipid metabolism - Schizosaccharomyces pombe (fission yeast)

Class

Metabolism; Lipid metabolism

Pathway map

spo00564

Glycerophospholipid metabolism

Module

spo_M00091

Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:spo00564]

spo_M00093

Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:spo00564]

Other DBs

GO:

0006650

Organism

Schizosaccharomyces pombe (fission yeast) [GN:spo]

Gene

2540455

gpd1; glycerol-3-phosphate dehydrogenase Gpd1 [KO:K00006] [EC:1.1.1.8]

2541502

gpd2; glycerol-3-phosphate dehydrogenase Gpd2 [KO:K00006] [EC:1.1.1.8]

2539217

gut2; glycerol-3-phosphate dehydrogenase Gut2 [KO:K00111] [EC:1.1.5.3]

2540110

sct1; glycerol-3-phosphate O-acyltransferase [KO:K13507] [EC:2.3.1.15 2.3.1.42]

2542560

slc1; 1-acylglycerol-3-phosphate O-acyltransferase Slc1 [KO:K13509] [EC:2.3.1.51]

2539940

ale1; MBOAT family O-acyltransferase [KO:K13519] [EC:2.3.1.51 2.3.1.23 2.3.1.-]

2542205

ptl3; triacylglycerol lipase [KO:K14674] [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]

2542362

vps66; acyltransferase [KO:K22831] [EC:2.3.1.51]

2541489

ayr1; 1-acyldihydroxyacetone phosphate reductase [KO:K06123] [EC:1.1.1.101]

2542274

ned1; lipin, phosphatidate phosphatase Ned1 [KO:K15728] [EC:3.1.3.4]

2541078

SPOM_SPBC409.18; phosphatidic acid phosphatase [KO:K18693] [EC:3.6.1.75 3.1.3.4]

2540998

ptp4; phosphatidate cytidylyltransferase Ptp4 [KO:K16368] [EC:2.7.1.174]

2543587

pgc1; glycerophosphoryl diester phosphodiesterase [KO:K18694] [EC:3.1.4.-]

2542065

pld1; phospholipase D Pld1 [KO:K01115] [EC:3.1.4.4]

2542889

SPOM_SPAC8E11.04C; palmitoyl-(protein) hydrolase [KO:K06130] [EC:3.1.1.5]

5802732

SPOM_SPBC1348.10C; phospholipase [KO:K13333] [EC:3.1.1.5]

2542220

plb3; lysophospholipase Plb3 [KO:K13333] [EC:3.1.1.5]

2542497

plb1; lysophospholipase 1 [KO:K13333] [EC:3.1.1.5]

2542164

plb2; phospholipase [KO:K13333] [EC:3.1.1.5]

2541836

plb4; phospholipase [KO:K13333] [EC:3.1.1.5]

2539134

plb5; phospholipase Plb5 [KO:K13333] [EC:3.1.1.5]

2539411

nte1; lysophospholipase [KO:K14676] [EC:3.1.1.5]

2543677

gde1; glycerophosphoryl diester phosphodiesterase Gde1 [KO:K18696] [EC:3.1.4.46]

2542839

eki1; choline kinase [KO:K00866] [EC:2.7.1.32]

2539176

pcy1; cholinephosphate cytidylyltransferase [KO:K00968] [EC:2.7.7.15]

2541829

ept1; CDP-alcohol phosphatidyltransferase class-I family protein [KO:K00993] [EC:2.7.8.1]

2542775

ect1; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]

2540995

cho1; putative phosphatidyl-N-methylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]

2540538

cho2; phosphatidylethanolamine N-methyltransferase Cho2 [KO:K16369] [EC:2.1.1.17]

2540017

bbl1; phosphatidate cytidylyltransferase [KO:K00981] [EC:2.7.7.41]

2538911

pps1; CDP-diacylglycerol-serine O-phosphatidyltransferase Pps1 [KO:K17103] [EC:2.7.8.8]

2541447

psd2; phosphatidylserine decarboxylase Psd2 [KO:K01613] [EC:4.1.1.65]

2543178

psd3; phosphatidylserine decarboxylase Psd3 [KO:K01613] [EC:4.1.1.65]

2539756

psd1; phosphatidylserine decarboxylase Psd1 [KO:K01613] [EC:4.1.1.65]

2541243

pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [KO:K00995] [EC:2.7.8.5]

2539038

gep4; cardiolipin synthase PGP phosphatase domain-containing Gep4 [KO:K01094] [EC:3.1.3.27]

2542281

cld1; cardiolipin-specific phospholipase Cld1 [KO:K13535] [EC:3.1.1.-]

2542487

pis1; phosphatidylinositol synthase (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) Pis1 [KO:K00999] [EC:2.7.8.11]

Compound

C00040

Acyl-CoA

C00065

L-Serine

C00084

Acetaldehyde

C00093

sn-Glycerol 3-phosphate

C00111

Glycerone phosphate

C00114

Choline

C00157

Phosphatidylcholine

C00189

Ethanolamine

C00269

CDP-diacylglycerol

C00307

CDP-choline

C00344

Phosphatidylglycerol

C00346

Ethanolamine phosphate

C00350

Phosphatidylethanolamine

C00416

Phosphatidate

C00513

CDP-glycerol

C00570

CDP-ethanolamine

C00588

Choline phosphate

C00623

sn-Glycerol 1-phosphate

C00641

1,2-Diacyl-sn-glycerol

C00670

sn-Glycero-3-phosphocholine

C00681

1-Acyl-sn-glycerol 3-phosphate

C01194

1-Phosphatidyl-D-myo-inositol

C01210

N-Methylethanolamine phosphate

C01233

sn-Glycero-3-phosphoethanolamine

C01241

Phosphatidyl-N-methylethanolamine

C01996

Acetylcholine

C02737

Phosphatidylserine

C03372

Acylglycerone phosphate

C03819

1-Acylglycerophosphoinositol

C03872

L-Serine-phosphoethanolamine

C03892

Phosphatidylglycerophosphate

C03974

2-Acyl-sn-glycerol 3-phosphate

C04230

1-Acyl-sn-glycero-3-phosphocholine

C04233

2-Acyl-sn-glycero-3-phosphocholine

C04308

Phosphatidyl-N-dimethylethanolamine

C04438

1-Acyl-sn-glycero-3-phosphoethanolamine

C04590

3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate

C04638

2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate

C05973

2-Acyl-sn-glycero-3-phosphoethanolamine

C05974

2-Acyl-sn-glycero-3-phosphoserine

C05976

Aminoacyl-phosphatidylglycerol

C05980

Cardiolipin

C06771

Triethanolamine

C06772

Diethanolamine

C13482

Phosphodimethylethanolamine

C18059

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol

C18125

1-Acyl-sn-glycero-3-phosphoserine

C18126

1-Acyl-sn-glycero-3-phosphoglycerol

C18129

Monolysocardiolipin

C18168

Diacylglycerylhomoserine

C18169

Diacylglyceryl-N,N,N-trimethylhomoserine

C20466

2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine

C20518

2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate

C22340

Heptaprenylglyceryl phosphate

C22341

Heptaprenylglycerol

C22342

Diacetylheptaprenylglycerol

Reference

PMID:1512203

Authors

Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.

Title

The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.

Journal

J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992

Reference

PMID:10092508

Authors

Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.

Title

Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.

Journal

Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411

Reference

PMID:10542045

Authors

Athenstaedt K, Daum G.

Title

Phosphatidic acid, a key intermediate in lipid metabolism.

Journal

Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x

Reference

PMID:12431977

Authors

Shields DJ, Lehner R, Agellon LB, Vance DE.

Title

Membrane topography of human phosphatidylethanolamine N-methyltransferase.

Journal

J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200

Reference

PMID:14663079

Authors

Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.

Title

Pathways for phosphatidylcholine biosynthesis in bacteria.

Journal

Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0

Reference

PMID:15522832

Authors

Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.

Title

Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.

Journal

Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007

Reference

PMID:1649829

Authors

Hsu L, Jackowski S, Rock CO

Title

Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.

Journal

J Biol Chem 266:13783-8 (1991)

Reference

PMID:10938271

Authors

Stone SJ, Vance JE.

Title

Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.

Journal

J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200

Related
pathway

spo00010