KEGG   PATHWAY: spu00480
Entry
spu00480                    Pathway                                
Name
Glutathione metabolism - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Metabolism of other amino acids
Pathway map
spu00480  Glutathione metabolism
spu00480

Module
spu_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:spu00480]
Other DBs
GO: 0006749
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
586229  glutathione hydrolase 2 isoform X2 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
583278  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
580355  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
592814  glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
585707  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100891710  glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
575501  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
584671  glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
575675  putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform X1 [KO:K07232] [EC:4.3.2.7]
589767  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
589474  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
590426  glutamate--cysteine ligase regulatory subunit [KO:K11205]
585694  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
591446  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
105437067  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
115921023  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
581093  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
115924033  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
590902  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
578352  aminopeptidase N isoform X3 [KO:K11140] [EC:3.4.11.2]
584441  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
590831  aminopeptidase N isoform X1 [KO:K11140] [EC:3.4.11.2]
115919332  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
115918303  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
590806  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
592805  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
115923973  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
574617  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
115924707  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
580123  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
115927263  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
587311  aminopeptidase Ey isoform X1 [KO:K11140] [EC:3.4.11.2]
100889727  glutamyl aminopeptidase [KO:K11140] [EC:3.4.11.2]
755759  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
115928304  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
579110  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
754063  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
583081  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
579788  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
574614  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
584003  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
588493  microsomal glutathione S-transferase 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
581106  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
574739  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
578378  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
587859  glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100893229  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
574676  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
756610  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
591844  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
579911  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
591076  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
753016  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
754437  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
105436784  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115929465  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
593100  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
593456  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
587704  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
582141  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
590176  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115920029  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115917905  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
588398  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
589776  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
115926743  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115918827  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115926457  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115918233  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
105443894  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
587401  glutathione S-transferase alpha M14-like [KO:K00799] [EC:2.5.1.18]
115927915  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
115927845  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
582092  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
585297  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
579729  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
587669  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
589095  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
593058  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
593074  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
593086  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
588420  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
581044  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
587692  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
580662  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
115918957  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
100888775  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
581825  hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
754374  probable glutathione S-transferase 6 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
580461  glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
105446747  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100892764  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
764071  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
754707  glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
592059  S-crystallin SL11 isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
592441  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100888935  S-crystallin 4 isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
752853  S-crystallin SL11-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
754207  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
586571  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100889420  glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
115918029  S-crystallin 4-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
580774  glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
581551  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
575696  glutathione S-transferase 3 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
590986  S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
589396  glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
581147  isocitrate dehydrogenase [NADP] cytoplasmic isoform X1 [KO:K00031] [EC:1.1.1.42]
580429  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
575941  LOW QUALITY PROTEIN: 6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
764148  glucose-6-phosphate 1-dehydrogenase X isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
586825  thioredoxin domain-containing protein 12 [KO:K05360] [EC:1.8.4.2]
581130  thioredoxin domain-containing protein 12 [KO:K05360] [EC:1.8.4.2]
105446740  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928699  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928810  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928836  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928859  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928587  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928830  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
115928720  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
588243  glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
587759  glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
105437350  glutathione peroxidase 7-like [KO:K00432] [EC:1.11.1.9]
115921720  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
579284  peroxiredoxin-6 isoform X1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
589060  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
105439774  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
591935  spermidine synthase [KO:K00797] [EC:2.5.1.16]
584264  spermine synthase [KO:K00802] [EC:2.5.1.22]
115919270  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
581431  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
577596  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
594140  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
PMID:12049631
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
PMID:12750367
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
PMID:12967709
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
PMID:12121990
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
PMID:15537651
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
PMID:12751784
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
PMID:18395526
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
PMID:11150302
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
PMID:12949079
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
PMID:12446213
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
PMID:10713147
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
PMID:17922848
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
PMID:12466271
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
PMID:14982633
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
spu00220  Arginine biosynthesis
spu00250  Alanine, aspartate and glutamate metabolism
spu00270  Cysteine and methionine metabolism
spu00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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