KEGG   PATHWAY: srpz00630
Entry
srpz00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Streptomyces sp. RPA4-2
Class
Metabolism; Carbohydrate metabolism
Pathway map
srpz00630  Glyoxylate and dicarboxylate metabolism
srpz00630

Module
srpz_M00012  Glyoxylate cycle [PATH:srpz00630]
srpz_M00621  Glycine cleavage system [PATH:srpz00630]
srpz_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:srpz00630]
Other DBs
GO: 0046487 0043648
Organism
Streptomyces sp. RPA4-2 [GN:srpz]
Gene
HEP85_02360  fdh; formate dehydrogenase [KO:K00123] [EC:1.17.1.9]
HEP85_02365  [KO:K00124]
HEP85_03415  [KO:K01847] [EC:5.4.99.2]
HEP85_03420  scpA; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
HEP85_04455  [KO:K00626] [EC:2.3.1.9]
HEP85_07550  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HEP85_08835  [KO:K01915] [EC:6.3.1.2]
HEP85_09255  [KO:K00127]
HEP85_12150  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HEP85_12235  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
HEP85_12285  glnII; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HEP85_12455  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
HEP85_12770  eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
HEP85_15240  [KO:K01647] [EC:2.3.3.1]
HEP85_16150  [KO:K00104] [EC:1.1.99.14]
HEP85_17070  [KO:K00626] [EC:2.3.1.9]
HEP85_18295  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
HEP85_18360  [KO:K01647] [EC:2.3.3.1]
HEP85_18560  [KO:K01091] [EC:3.1.3.18]
HEP85_21115  [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
HEP85_21775  [KO:K00122] [EC:1.17.1.9]
HEP85_24565  [KO:K00024] [EC:1.1.1.37]
HEP85_24645  [KO:K00600] [EC:2.1.2.1]
HEP85_24860  [KO:K01848] [EC:5.4.99.2]
HEP85_25145  [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
HEP85_25165  [KO:K27095]
HEP85_25170  [KO:K27094]
HEP85_25780  [KO:K03781] [EC:1.11.1.6]
HEP85_26540  [KO:K03781] [EC:1.11.1.6]
HEP85_26910  [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
HEP85_27375  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HEP85_27520  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
HEP85_27525  [KO:K00626] [EC:2.3.1.9]
HEP85_27885  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HEP85_27890  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HEP85_27895  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HEP85_29665  [KO:K01647] [EC:2.3.3.1]
HEP85_29670  [KO:K01647] [EC:2.3.3.1]
HEP85_30060  acnA; aconitate hydratase AcnA [KO:K27802]
HEP85_31030  [KO:K01895] [EC:6.2.1.1]
HEP85_31045  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
HEP85_31060  [KO:K03781] [EC:1.11.1.6]
HEP85_31065  [KO:K00042] [EC:1.1.1.60]
HEP85_31070  [KO:K01816] [EC:5.3.1.22]
HEP85_31205  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
HEP85_31750  [KO:K00865] [EC:2.7.1.165]
HEP85_31810  [KO:K14447] [EC:5.4.99.63]
HEP85_32315  frc; formyl-CoA transferase [KO:K07749] [EC:2.8.3.16]
HEP85_33225  [KO:K00626] [EC:2.3.1.9]
HEP85_34770  [KO:K01625] [EC:4.1.2.14 4.1.3.42]
HEP85_35075  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HEP85_37275  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
HEP85_42795  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HEP85_43245  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
HEP85_43250  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
HEP85_43360  [KO:K01647] [EC:2.3.3.1]
HEP85_44275  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
srpz00010  Glycolysis / Gluconeogenesis
srpz00020  Citrate cycle (TCA cycle)
srpz00030  Pentose phosphate pathway
srpz00053  Ascorbate and aldarate metabolism
srpz00071  Fatty acid degradation
srpz00230  Purine metabolism
srpz00250  Alanine, aspartate and glutamate metabolism
srpz00260  Glycine, serine and threonine metabolism
srpz00270  Cysteine and methionine metabolism
srpz00620  Pyruvate metabolism
srpz00710  Carbon fixation by Calvin cycle
srpz00750  Vitamin B6 metabolism
srpz00910  Nitrogen metabolism
KO pathway
ko00630   

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