Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis - Streptomyces sp. Mg1

Hertweck C

The biosynthetic logic of polyketide diversity.

Angew Chem Int Ed Engl 48:4688-716 (2009)
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Long PF, Wilkinson CJ, Bisang CP, Cortes J, Dunster N, Oliynyk M, McCormick E, McArthur H, Mendez C, Salas JA, Staunton J, Leadlay PF

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase.

Mol Microbiol 43:1215-25 (2002)
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Bisang C, Long PF, Cortes J, Westcott J, Crosby J, Matharu AL, Cox RJ, Simpson TJ, Staunton J, Leadlay PF

A chain initiation factor common to both modular and aromatic polyketide synthases.

Nature 401:502-5 (1999)
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Katz L

The DEBS paradigm for type I modular polyketide synthases and beyond.

Methods Enzymol 459:113-42 (2009)
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Kittendorf JD, Beck BJ, Buchholz TJ, Seufert W, Sherman DH

Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase.

Chem Biol 14:944-54 (2007)
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Beck BJ, Yoon YJ, Reynolds KA, Sherman DH

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase.

Chem Biol 9:575-83 (2002)
DOI:10.1016/S1074-5521(02)00146-1

Chen S, Roberts JB, Xue Y, Sherman DH, Reynolds KA

The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide.

Gene 263:255-64 (2001)
DOI:10.1016/S0378-1119(00)00560-6

Kim BS, Cropp TA, Beck BJ, Sherman DH, Reynolds KA

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin.

J Biol Chem 277:48028-34 (2002)
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Ikeda H, Omura S

Avermectin Biosynthesis.

Chem Rev 97:2591-2610 (1997)
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Ikeda H, Nonomiya T, Omura S

Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.

J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092

Volchegursky Y, Hu Z, Katz L, McDaniel R

Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.

Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x

Peiru S, Menzella HG, Rodriguez E, Carney J, Gramajo H

Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.

Appl Environ Microbiol 71:2539-47 (2005)
DOI:10.1128/AEM.71.5.2539-2547.2005

Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H

TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.

Appl Environ Microbiol 76:3869-77 (2010)
DOI:10.1128/AEM.03083-09

Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.

Proc Natl Acad Sci U S A 98:14808-13 (2001)
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Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B

Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.

J Biol Chem 284:29170-9 (2009)
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Hsieh YJ, Kolattukudy PE.

Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea.

J Bacteriol 176:714-24 (1994)
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Donadio S, Staver MJ, Katz L.

Erythromycin production in Saccharopolyspora erythraea does not require a functional propionyl-CoA carboxylase.

Mol Microbiol 19:977-84 (1996)
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Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.

Microbiology 143:3251-62 (1997)
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Rawlings BJ.

Type I polyketide biosynthesis in bacteria (part B).

Nat Prod Rep 18:231-81 (2001)
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Rawlings BJ.

Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).

Nat Prod Rep 18:190-227 (2001)
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Borisova SA, Liu HW

Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.

Biochemistry 49:8071-84 (2010)
DOI:10.1021/bi1007657

Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ

Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.

Gene 386:123-30 (2007)
DOI:10.1016/j.gene.2006.08.021

Rodriguez E, Peiru S, Carney JR, Gramajo H

In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.

Microbiology 152:667-73 (2006)
DOI:10.1099/mic.0.28680-0

Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF

Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII.

J Mol Biol 415:92-101 (2012)
DOI:10.1016/j.jmb.2011.10.036

Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.

J Am Chem Soc 127:14128-9 (2005)
DOI:10.1021/ja053704n

Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.

J Biol Chem 281:26289-97 (2006)
DOI:10.1074/jbc.M605478200

Li S, Ouellet H, Sherman DH, Podust LM

Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae.

J Biol Chem 284:5723-30 (2009)
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