KEGG   PATHWAY: surl00260
Entry
surl00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Sporosarcina ureilytica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
surl00260  Glycine, serine and threonine metabolism
surl00260

Module
surl_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:surl00260]
surl_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:surl00260]
surl_M00621  Glycine cleavage system [PATH:surl00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sporosarcina ureilytica [GN:surl]
Gene
BI350_06940  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BI350_01055  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BI350_13055  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BI350_12225  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BI350_00205  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BI350_01050  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BI350_01040  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BI350_01045  threonine synthase [KO:K01733] [EC:4.2.3.1]
BI350_15625  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BI350_16280  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BI350_03895  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BI350_09555  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BI350_09525  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
BI350_04550  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BI350_05800  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BI350_00470  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BI350_00475  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BI350_05790  haloacid dehalogenase [KO:K25528] [EC:3.1.3.3]
BI350_15950  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BI350_10050  glycine dehydrogenase (aminomethyl-transferring) [KO:K00282] [EC:1.4.4.2]
BI350_10045  glycine dehydrogenase (aminomethyl-transferring) [KO:K00283] [EC:1.4.4.2]
BI350_10055  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BI350_09835  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BI350_13185  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BI350_04810  glycine cleavage system protein H [KO:K02437]
BI350_12675  L-serine dehydratase, iron-sulfur-dependent subunit alpha [KO:K01752] [EC:4.3.1.17]
BI350_12680  L-serine dehydratase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
BI350_09700  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BI350_10955  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BI350_01720  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BI350_01520  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BI350_01515  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
surl00010  Glycolysis / Gluconeogenesis
surl00020  Citrate cycle (TCA cycle)
surl00230  Purine metabolism
surl00250  Alanine, aspartate and glutamate metabolism
surl00270  Cysteine and methionine metabolism
surl00290  Valine, leucine and isoleucine biosynthesis
surl00300  Lysine biosynthesis
surl00330  Arginine and proline metabolism
surl00460  Cyanoamino acid metabolism
surl00470  D-Amino acid metabolism
surl00564  Glycerophospholipid metabolism
surl00620  Pyruvate metabolism
surl00630  Glyoxylate and dicarboxylate metabolism
surl00640  Propanoate metabolism
surl00680  Methane metabolism
surl00860  Porphyrin metabolism
surl00920  Sulfur metabolism
KO pathway
ko00260   
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