KEGG   PATHWAY: vpd00350
Entry
vpd00350                    Pathway                                
Name
Tyrosine metabolism - Variovorax paradoxus B4
Class
Metabolism; Amino acid metabolism
Pathway map
vpd00350  Tyrosine metabolism
vpd00350

Module
vpd_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:vpd00350]
vpd_M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:vpd00350]
Other DBs
GO: 0006570
Organism
Variovorax paradoxus B4 [GN:vpd]
Gene
VAPA_1c01060  [KO:K01555] [EC:3.7.1.2]
VAPA_1c02930  [KO:K02510] [EC:4.1.2.52]
VAPA_1c02940  [KO:K02509] [EC:4.2.1.-]
VAPA_1c02950  [KO:K01826] [EC:5.3.3.10]
VAPA_1c02960  [KO:K00455] [EC:1.13.11.15]
VAPA_1c02970  [KO:K00151] [EC:1.2.1.60]
VAPA_1c02980  [KO:K05921] [EC:4.1.1.68 5.3.3.-]
VAPA_1c02990  [KO:K05921] [EC:4.1.1.68 5.3.3.-]
VAPA_1c03500  [KO:K01555] [EC:3.7.1.2]
VAPA_1c03510  hmgA; homogentisate 1,2-dioxygenase HmgA [KO:K00451] [EC:1.13.11.5]
VAPA_1c03770  aat1; aspartate aminotransferase Aat [KO:K00812] [EC:2.6.1.1]
VAPA_1c04190  [KO:K00450] [EC:1.13.11.4]
VAPA_1c04200  [KO:K16165] [EC:3.7.1.20]
VAPA_1c06860  maiA; maleylacetoacetate isomerase MaiA [KO:K01801] [EC:5.2.1.4]
VAPA_1c06990  [KO:K00450] [EC:1.13.11.4]
VAPA_1c07000  [KO:K16165] [EC:3.7.1.20]
VAPA_1c08430  [KO:K13574] [EC:1.1.1.237 1.1.1.-]
VAPA_1c12260  hisC1; histidinol-phosphate aminotransferase HisC [KO:K00817] [EC:2.6.1.9]
VAPA_1c15710  hisC2; histidinol-phosphate aminotransferase HisC [KO:K00817] [EC:2.6.1.9]
VAPA_1c17910  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
VAPA_1c20830  hpcH; 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase HpcH [KO:K02510] [EC:4.1.2.52]
VAPA_1c20840  gabD1; succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
VAPA_1c21390  [KO:K16165] [EC:3.7.1.20]
VAPA_1c21400  [KO:K01800] [EC:5.2.1.2]
VAPA_1c22430  hisC3; histidinol-phosphate aminotransferase HisC [KO:K00817] [EC:2.6.1.9]
VAPA_1c22500  [KO:K02510] [EC:4.1.2.52]
VAPA_1c22520  gabD2; succinate-semialdehyde dehydrogenase NADP+ [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
VAPA_1c22640  [KO:K05921] [EC:4.1.1.68 5.3.3.-]
VAPA_1c22650  [KO:K05921] [EC:4.1.1.68 5.3.3.-]
VAPA_1c22660  hpcC; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase HpcC [KO:K00151] [EC:1.2.1.60]
VAPA_1c22670  hpcB; 3,4-dihydroxyphenylacetate 2,3-dioxygenase HpcB [KO:K00455] [EC:1.13.11.15]
VAPA_1c22680  hpcG; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase HpcG [KO:K02509] [EC:4.2.1.-]
VAPA_1c23090  [KO:K00832] [EC:2.6.1.57]
VAPA_1c24260  [KO:K00817] [EC:2.6.1.9]
VAPA_1c29970  [KO:K00817] [EC:2.6.1.9]
VAPA_1c36660  [KO:K16165] [EC:3.7.1.20]
VAPA_1c40430  [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
VAPA_1c48550  gabD3; succinate-semialdehyde dehydrogenase NADP+ [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
VAPA_1c49220  hpd; 4-hydroxyphenylpyruvate dioxygenase Hpd [KO:K00457] [EC:1.13.11.27]
VAPA_1c49490  [KO:K16171] [EC:3.7.1.2]
VAPA_2c02560  gabD; succinate-semialdehyde dehydrogenase NADP+ [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
VAPA_2c03310  adh; alcohol dehydrogenase Adh [KO:K13953] [EC:1.1.1.1]
VAPA_2c03430  [KO:K13953] [EC:1.1.1.1]
VAPA_2c07380  [KO:K00812] [EC:2.6.1.1]
VAPA_2c11760  palB; putative aminotransferase PalB [KO:K00812] [EC:2.6.1.1]
VAPA_2c12050  [KO:K00832] [EC:2.6.1.57]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
C23042  Atromentin
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
vpd00020  Citrate cycle (TCA cycle)
vpd00360  Phenylalanine metabolism
vpd00400  Phenylalanine, tyrosine and tryptophan biosynthesis
vpd00620  Pyruvate metabolism
vpd00621  Dioxin degradation
vpd00650  Butanoate metabolism
KO pathway
ko00350   

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