KEGG   PATHWAY: ypi00260
Entry
ypi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yersinia pseudotuberculosis IP 31758 (serotype O:1b)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ypi00260  Glycine, serine and threonine metabolism
ypi00260

Module
ypi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ypi00260]
ypi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ypi00260]
ypi_M00555  Betaine biosynthesis, choline => betaine [PATH:ypi00260]
ypi_M00621  Glycine cleavage system [PATH:ypi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yersinia pseudotuberculosis IP 31758 (serotype O:1b) [GN:ypi]
Gene
YpsIP31758_0301  asparate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
YpsIP31758_3476  thrA; bifunctional aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
YpsIP31758_0122  metL; bifunctional aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
YpsIP31758_4013  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
YpsIP31758_3475  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
YpsIP31758_3474  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
YpsIP31758_2620  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
YpsIP31758_1158  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
YpsIP31758_4137  tkrA; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
YpsIP31758_4052  glycerate kinase [KO:K00865] [EC:2.7.1.165]
YpsIP31758_2861  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
YpsIP31758_3480  phosphoglycerate mutase family protein [KO:K15634] [EC:5.4.2.11]
YpsIP31758_0075  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
YpsIP31758_0856  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YpsIP31758_2694  D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YpsIP31758_2583  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
YpsIP31758_3493  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
YpsIP31758_1864  oxidoreductase, short chain dehydrogenase/reductase family protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
YpsIP31758_0071  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
YpsIP31758_0072  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
YpsIP31758_0865  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
YpsIP31758_0863  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
YpsIP31758_0135  pyridine nucleotide-disulfide oxidoreductase family protein [KO:K00382] [EC:1.8.1.4]
YpsIP31758_3360  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
YpsIP31758_0864  gcvH; glycine cleavage system H protein [KO:K02437]
YpsIP31758_3207  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
YpsIP31758_2831  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
YpsIP31758_2830  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
YpsIP31758_2355  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
YpsIP31758_4146  putative threonine ammonia-lyase, catabolic [KO:K01754] [EC:4.3.1.19]
YpsIP31758_0158  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
YpsIP31758_1412  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
YpsIP31758_1652  alr1; alanine racemase [KO:K25317] [EC:5.1.1.10]
YpsIP31758_1937  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
YpsIP31758_1936  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
YpsIP31758_2448  pyridoxal-dependent decarboxylase domain protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ypi00010  Glycolysis / Gluconeogenesis
ypi00020  Citrate cycle (TCA cycle)
ypi00230  Purine metabolism
ypi00250  Alanine, aspartate and glutamate metabolism
ypi00270  Cysteine and methionine metabolism
ypi00290  Valine, leucine and isoleucine biosynthesis
ypi00300  Lysine biosynthesis
ypi00330  Arginine and proline metabolism
ypi00460  Cyanoamino acid metabolism
ypi00470  D-Amino acid metabolism
ypi00564  Glycerophospholipid metabolism
ypi00600  Sphingolipid metabolism
ypi00620  Pyruvate metabolism
ypi00630  Glyoxylate and dicarboxylate metabolism
ypi00640  Propanoate metabolism
ypi00680  Methane metabolism
ypi00860  Porphyrin metabolism
ypi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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