Membrane Trafficking - Homo sapiens (human)

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     KO
 Exocytosis
   Calcium ion-dependent exocytosis
     Synaptotagmins
     Septins
     DOC-2 proteins
     Acrosomal exocytosis proteins
       49 ACR; acrosin
       2683 B4GALT1; beta-1,4-galactosyltransferase 1
       10321 CRISP3; cysteine rich secretory protein 3
       167 CRISP1; cysteine rich secretory protein 1
       7180 CRISP2; cysteine rich secretory protein 2
       54586 EQTN; equatorin
       2741 GLRA1; glycine receptor alpha 1
       2743 GLRB; glycine receptor beta
       54760 PCSK4; proprotein convertase subtilisin/kexin type 4
       5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
       10343 PKDREJ; polycystin family receptor for egg jelly
       22999 RIMS1; regulating synaptic membrane exocytosis 1
       9699 RIMS2; regulating synaptic membrane exocytosis 2
       9783 RIMS3; regulating synaptic membrane exocytosis 3
       140730 RIMS4; regulating synaptic membrane exocytosis 4
       9256 TSPOAP1; TSPO associated protein 1
       6382 SDC1; syndecan 1
       246777 SPESP1; sperm equatorial segment protein 1
       153218 SPINK13; serine peptidase inhibitor Kazal type 13
       7142 TNP2; transition protein 2
       55521 TRIM36; tripartite motif containing 36
       22917 ZP1; zona pellucida glycoprotein 1
       7783 ZP2; zona pellucida glycoprotein 2
       7784 ZP3; zona pellucida glycoprotein 3
K01317 ACR; acrosin [EC:3.4.21.10] 
K07966 B4GALT1; beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-] 
K19919 CRISP; cysteine-rich secretory protein 
K19919 CRISP; cysteine-rich secretory protein 
K19919 CRISP; cysteine-rich secretory protein 
K19920 EQTN; equatorin 
K05193 GLRA1; glycine receptor alpha-1 
K05196 GLRB; glycine receptor beta 
K08671 PCSK4; proprotein convertase subtilisin/kexin type 4 [EC:3.4.21.-] 
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1] 
K19921 PKDREJ; polycystic kidney disease and receptor for egg jelly-related protein 
K15291 RIMS1; regulating synaptic membrane exocytosis protein 1 
K15297 RIMS2; regulating synaptic membrane exocytosis protein 2 
K15298 RIMS3; regulating synaptic membrane exocytosis protein 3 
K15299 RIMS4; regulating synaptic membrane exocytosis protein 4 
K19922 BZRAP1; peripheral-type benzodiazepine receptor-associated protein 1 
K06257 SDC1; syndecan 1 
K19923 SPESP1; sperm equatorial segment protein 1 
K19924 SPINK13; serine protease inhibitor Kazal-type 13 
K19925 TNP2; nuclear transition protein 2 
K12013 TRIM36; tripartite motif-containing protein 36 [EC:2.3.2.27] 
K19926 ZP1; zona pellucida sperm-binding protein 1 
K19927 ZP2; zona pellucida sperm-binding protein 2 
K19928 ZP3; zona pellucida sperm-binding protein 3 
     Phospholipases
     Kinases and associated proteins
     Others
   Small GTPases and associated proteins
     Rab GTPases
     Rab associated proteins
       117177 RAB3IP; RAB3A interacting protein
       5866 RAB3IL1; RAB3A interacting protein like 1
       22930 RAB3GAP1; RAB3 GTPase activating protein catalytic subunit 1
       25782 RAB3GAP2; RAB3 GTPase activating non-catalytic protein subunit 2
       22895 RPH3A; rabphilin 3A
       9501 RPH3AL; rabphilin 3A like (without C2 domains)
       87 ACTN1; actinin alpha 1
       81 ACTN4; actinin alpha 4
       89 ACTN3; actinin alpha 3
       88 ACTN2; actinin alpha 2
       810 CALML3; calmodulin like 3
       805 CALM2; calmodulin 2
       808 CALM3; calmodulin 3
       801 CALM1; calmodulin 1
       163688 CALML6; calmodulin like 6
       51806 CALML5; calmodulin like 5
       91860 CALML4; calmodulin like 4
       6853 SYN1; synapsin I
       6854 SYN2; synapsin II
       8224 SYN3; synapsin III
       54843 SYTL2; synaptotagmin like 2
       84958 SYTL1; synaptotagmin like 1
       94120 SYTL3; synaptotagmin like 3
       94121 SYTL4; synaptotagmin like 4
       94122 SYTL5; synaptotagmin like 5
       6812 STXBP1; syntaxin binding protein 1
       134957 STXBP5; syntaxin binding protein 5
       9515 STXBP5L; syntaxin binding protein 5 like
       9342 SNAP29; synaptosome associated protein 29
       22999 RIMS1; regulating synaptic membrane exocytosis 1
       9699 RIMS2; regulating synaptic membrane exocytosis 2
       5877 RABIF; RAB interacting factor
       2622 GAS8; growth arrest specific 8
       11130 ZWINT; ZW10 interacting kinetochore protein
       4952 OCRL; OCRL inositol polyphosphate-5-phosphatase
       3633 INPP5B; inositol polyphosphate-5-phosphatase B
       23216 TBC1D1; TBC1 domain family member 1
       9882 TBC1D4; TBC1 domain family member 4
       79774 GRTP1; growth hormone regulated TBC protein 1
       11138 TBC1D8; TBC1 domain family member 8
       54885 TBC1D8B; TBC1 domain family member 8B
       23158 TBC1D9; TBC1 domain family member 9
       23061 TBC1D9B; TBC1 domain family member 9B
       374403 TBC1D10C; TBC1 domain family member 10C
       26000 TBC1D10B; TBC1 domain family member 10B
       83874 TBC1D10A; TBC1 domain family member 10A
       79735 TBC1D17; TBC1 domain family member 17
       10133 OPTN; optineurin
       57553 MICAL3; microtubule associated monooxygenase, calponin and LIM domain containing 3
       64780 MICAL1; microtubule associated monooxygenase, calponin and LIM domain containing 1
       9645 MICAL2; microtubule associated monooxygenase, calponin and LIM domain containing 2
       85377 MICALL1; MICAL like 1
       79778 MICALL2; MICAL like 2
       5830 PEX5; peroxisomal biogenesis factor 5
       51555 PEX5L; peroxisomal biogenesis factor 5 like
       9381 OTOF; otoferlin
       3993 LLGL2; LLGL scribble cell polarity complex component 2
       3996 LLGL1; LLGL scribble cell polarity complex component 1
       1121 CHM; CHM Rab escort protein
       1122 CHML; CHM like Rab escort protein
       5875 RABGGTA; Rab geranylgeranyltransferase subunit alpha
       5876 RABGGTB; Rab geranylgeranyltransferase subunit beta
       79083 MLPH; melanophilin
       23086 EXPH5; exophilin 5
       25924 MYRIP; myosin VIIA and Rab interacting protein
       1657 DMXL1; Dmx like 1
       23312 DMXL2; Dmx like 2
K16779 RAB3IP; Rab-3A-interacting protein 
K16779 RAB3IP; Rab-3A-interacting protein 
K18270 RAB3GAP1; Rab3 GTPase-activating protein catalytic subunit 
K19937 RAB3GAP2; Rab3 GTPase-activating protein non-catalytic subunit 
K19938 RPH3A; rabphilin-3A 
K19939 RPH3AL; Rab effector Noc2 
K05699 ACTN1_4; actinin alpha 1/4 
K05699 ACTN1_4; actinin alpha 1/4 
K21073 ACTN2_3; actinin alpha 2/3 
K21073 ACTN2_3; actinin alpha 2/3 
K02183 CALM; calmodulin 
K02183 CALM; calmodulin 
K02183 CALM; calmodulin 
K02183 CALM; calmodulin 
K02183 CALM; calmodulin 
K02183 CALM; calmodulin 
K02183 CALM; calmodulin 
K19941 SYN; synapsin 
K19941 SYN; synapsin 
K19941 SYN; synapsin 
K17598 SYTL; synaptotagmin-like protein 
K17598 SYTL; synaptotagmin-like protein 
K17598 SYTL; synaptotagmin-like protein 
K17598 SYTL; synaptotagmin-like protein 
K17598 SYTL; synaptotagmin-like protein 
K15292 STXBP1; syntaxin-binding protein 1 
K08518 STXBP5; syntaxin-binding protein 5 
K08518 STXBP5; syntaxin-binding protein 5 
K08509 SNAP29; synaptosomal-associated protein 29 
K15291 RIMS1; regulating synaptic membrane exocytosis protein 1 
K15297 RIMS2; regulating synaptic membrane exocytosis protein 2 
K19952 RABIF; guanine nucleotide exchange factor 
K19942 GAS8; growth arrest-specific protein 8 
K19943 ZWINT; ZW10 interactor 
K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36] 
K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36] 
K18341 TBC1D1; TBC1 domain family member 1 
K17902 TBC1D4; TBC1 domain family member 4 
K19953 GRTP1; TBC1 domain family member 6 
K19951 TBC1D8_9; TBC1 domain family member 8/9 
K19951 TBC1D8_9; TBC1 domain family member 8/9 
K19951 TBC1D8_9; TBC1 domain family member 8/9 
K19951 TBC1D8_9; TBC1 domain family member 8/9 
K19944 TBC1D10; TBC1 domain family member 10 
K19944 TBC1D10; TBC1 domain family member 10 
K19944 TBC1D10; TBC1 domain family member 10 
K19945 TBC1D17; TBC1 domain family member 17 
K19946 OPTN; optineurin 
K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225] 
K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225] 
K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225] 
K19948 MICALL1; MICAL-like protein 1 
K21068 MICALL2; MICAL-like protein 2 
K13342 PEX5; peroxin-5 
K13342 PEX5; peroxin-5 
K19949 OTOF; otoferlin 
K06094 LLGL; lethal(2) giant larvae protein 
K06094 LLGL; lethal(2) giant larvae protein 
K23460 CHM; Rab proteins geranylgeranyltransferase component A 
K23460 CHM; Rab proteins geranylgeranyltransferase component A 
K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60] 
K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60] 
K22235 MLPH; melanophilin 
K22236 EXPH5; exophilin-5 
K22237 MYRIP; Rab effector MyRIP 
K24155 DMXL; DmX-like protein 
K24155 DMXL; DmX-like protein 
     Rho GTPases
   Tethering complex
   Others
 
 SNARE
 
 Endocytosis
 
 Endosome - Lysosome transport
 
 Protein recycling
 
 Endosome - Golgi transport
 
 Endoplasmic reticulum (ER) - Golgi transport
 
 Autophagy
 
 Others

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Last updated: December 23, 2020