KEGG ORTHOLOGY: K19949

ORTHOLOGY: K19949

Entry

K19949                      KO

Symbol

OTOF

Name

otoferlin

Disease

H00605

Deafness, autosomal recessive

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K19949  OTOF; otoferlin
Membrane trafficking [BR:ko04131]
Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K19949  OTOF; otoferlin

Other DBs

GO:

0035612

Genes

HSA:	9381(OTOF)

PTR:	459083(OTOF)

PPS:	100980705(OTOF)

GGO:	101128177(OTOF)

PON:	100455478(OTOF)

PPYG:

129030068(OTOF)

NLE:	100596202(OTOF)

HMH:	116480447(OTOF)

SSYN:

129467253(OTOF)

MCC:	696717(OTOF)

MCF:	102141058(OTOF)

MTHB:

126933761

MNI:	105479784(OTOF)

CSAB:

103220633(OTOF)

CATY:

105578497(OTOF)

PANU:

101018741(OTOF)

TGE:	112604720(OTOF)

MLEU:

105534065(OTOF)

RRO:	104677897(OTOF)

RBB:	108532767(OTOF)

TFN:	117062597(OTOF)

PTEH:

111554471(OTOF)

CANG:

105517616(OTOF)

CJC:	100408695(OTOF)

SBQ:	101042656(OTOF)

CIMI:

108315896(OTOF)

ANAN:

105733232(OTOF)

CSYR:

103270548(OTOF)

MMUR:

105884374(OTOF)

LCAT:

123636694(OTOF)

PCOQ:

105816911(OTOF)

OGA:	100957414(OTOF)

MMU:	83762(Otof)

MCAL:

110293846(Otof)

MPAH:

110324811(Otof)

RNO:	84573(Otof)

MCOC:

116079961(Otof)

ANU:	117716945(Otof)

ASYL:

127686733(Otof)

MUN:	110547706(Otof)

CGE:	100759573(Otof)

MAUA:

101837431(Otof)

PROB:

127220065(Otof)

PLEU:

114696535(Otof)

MORG:

121432879 121439643

MFOT:

126492246

AAMP:

119806918(Otof)

NGI:	103735665(Otof)

HGL:	101698163(Otof)

CPOC:

100730931(Otof)

CCAN:

109699096(Otof)

DORD:

105983613(Otof)

DSP:	122122466(Otof)

PLOP:

125356930(Otof)

NCAR:

124963089

MMMA:

107137439(Otof)

ITI:	101978664(Otof)

OCU:

100354010

OPI:	101533088(OTOF)

TUP:	102470675(OTOF)

GVR:	103582007(OTOF)

CFA:	607961(OTOF)

CLUD:

112664657(OTOF)

VVP:	112908503(OTOF)

VLG:	121490965(OTOF)

NPO:	129511005(OTOF)

AML:	100479400(OTOF)

UMR:	103671923(OTOF)

UAH:	113270860(OTOF)

UAR:	123799934(OTOF)

ELK:

111154097

LLV:

125109934

MPUF:

101688673(OTOF)

MNP:	132022247(OTOF)

MLK:	131807273(OTOF)

NVS:	122915795(OTOF)

ORO:	101363283(OTOF)

EJU:	114205971(OTOF)

ZCA:	113938360(OTOF)

MLX:	118007406(OTOF)

NSU:	110587148(OTOF)

LWW:	102750436(OTOF)

FCA:	101083509(OTOF)

PYU:	121044223(OTOF)

PCOO:

112864098(OTOF)

PBG:	122497363(OTOF)

PVIV:

125162850(OTOF)

LRUF:

124503574

LGF:	123581398(OTOF)

AJU:

106967907

PTG:	102949330(OTOF)

PPAD:

109262711(OTOF)

PUC:

125937616

PLEZ:

122216532(OTOF)

HHV:	120235842(OTOF)

BTA:	617299(OTOF)

BOM:	102264385(OTOF)

BIU:	109566310(OTOF)

BBUB:

102396005(OTOF)

BBIS:

104989123(OTOF)

CHX:	102181693(OTOF)

OAS:	101111175(OTOF)

BTAX:

128055275(OTOF)

CSUM:

138087198(OTOF)

ODA:	120851583(OTOF)

CCAD:

122441972(OTOF)

MREE:

136162749(OTOF)

OVR:	110150769(OTOF)

MBEZ:

129539214(OTOF)

SSC:	100737937(OTOF)

CFR:	102522842(OTOF)

CBAI:

105063855(OTOF) 105074226

CDK:	105098515(OTOF)

VPC:	102527417(OTOF)

BACU:

103004941(OTOF)

BMUS:

118906503(OTOF)

LVE:	103088353(OTOF)

OOR:	101288561(OTOF)

LALB:

132531057(OTOF)

DLE:	111174764(OTOF)

PCAD:

102995179(OTOF)

PSIU:

116764249(OTOF)

NASI:

112412779(OTOF)

ECB:	100071343(OTOF)

EPZ:	103546457(OTOF)

EAI:	106832680(OTOF)

MYB:	102261809(OTOF)

MYD:	102756134(OTOF)

MMYO:

118669202(OTOF)

MLF:	102423619(OTOF)

MDT:	132213724(OTOF)

MYUM:

139019749(OTOF)

PKL:	118717217(OTOF)

EFUS:

103305538(OTOF)

MNA:	107534882(OTOF)

DRO:	112298107(OTOF)

SHON:

119001240(OTOF)

AJM:	119050446(OTOF)

PDIC:

114499246(OTOF)

PHAS:

123822459(OTOF)

MMF:	118630615(OTOF)

PPAM:

129065029(OTOF)

HAI:	109382606(OTOF)

RFQ:	117033288(OTOF)

PALE:

102890486(OTOF)

PGIG:

120621869(OTOF)

PVP:	105289750(OTOF)

RAY:	107505203(OTOF)

MJV:	108391217(OTOF)

TOD:	119259489(OTOF)

SARA:

101543850(OTOF)

SFUM:

130031685(OTOF)

SETR:

126024023(OTOF)

LAV:	100676144(OTOF)

TMU:

101354001

ETF:

101650581

DNM:	101415007(OTOF)

MDO:	100025656(OTOF)

GAS:	123234998(OTOF)

SHR:	100928554(OTOF)

AFZ:

127548766

PCW:	110206504(OTOF)

TVP:	118843039(OTOF)

PBRV:

138148983(OTOF)

OAA:	103170127(OTOF)

TACU:

119932015(OTOF)

GGA:	422007(OTOF)

PCOC:

116235625(OTOF)

MGP:	100551454(OTOF)

CJO:	107312424(OTOF)

TPAI:

128084589(OTOF)

LMUT:

125689750(OTOF)

NMEL:

110396621(OTOF)

APLA:

101789780(OTOF)

ACYG:

106038199(OTOF)

CATA:

118256523(OTOF)

AFUL:

116487686(OTOF)

TGU:	115494589(OTOF)

LSR:	110479889(OTOF)

SCAN:

103824562(OTOF)

PMOA:

120504172(OTOF)

OTC:	121336228(OTOF)

PRUF:

121357882(OTOF)

ATRC:

139584853(OTOF)

GFR:	102041419(OTOF)

FAB:	101810022(OTOF)

OMA:	130250664(OTOF)

PHI:	102111966(OTOF)

PMAJ:

107198812(OTOF)

CCAE:

111927325(OTOF)

CCW:	104683142(OTOF)

CBRC:

103616394

ACOE:

138108790(OTOF)

ZAB:

102073218

ZLE:	135446261(OTOF)

ACHL:

103809522

SVG:	106860366(OTOF)

MMEA:

130586160

HRT:	120750263(OTOF)

SATI:

136358663(OTOF)

CCIC:

134041539(OTOF)

FPG:	101923819(OTOF)

FCH:	102049256(OTOF)

CCRI:

104167817

NNT:

104410255

SHAB:

115609803(OTOF)

ACUN:

113478312(OTOF)

TALA:

104356034(OTOF)

ACHC:

115350840(OTOF)

HALD:

104314101

HLE:	104841490(OTOF)

AGEN:

126046525

HHAR:

128151890(OTOF)

GCL:

127014193

CSTI:

104557716(OTOF)

MNB:	103782217(OTOF)

DPUB:

104307331(OTOF)

PPUS:

135176995(OTOF)

AVIT:

104270547

BRHI:

104493520

EGZ:	104130937(OTOF)

NNI:	104014777(OTOF)

PCRI:

104035866(OTOF)

PCAO:

104053062

PADL:

103923915(OTOF)

AFOR:

103895535(OTOF)

FGA:

104080472

GSTE:

104263903(OTOF)

CBOY:

140649864(OTOF)

CLV:

102087372

PGUU:

104470737

PLET:

104618735

CMAC:

104477613(OTOF)

CUCA:

104061772(OTOF)

TEO:

104378641

BREG:

104634771

OHA:

104338319

ACAR:

104528660(OTOF)

CPEA:

104392773(OTOF)

CVF:	104291165(OTOF)

RTD:	128906669(OTOF)

CRID:

134513693(OTOF)

AAM:	106486440(OTOF)

AROW:

112960790(OTOF)

NPD:	112955309(OTOF)

TGT:	104566807(OTOF)

DNE:	112992946(OTOF)

ASN:	102367739(OTOF)

AMJ:	106737038(OTOF)

CPOO:

109312067(OTOF)

GGN:	109300223(OTOF)

CMY:	102939484(OTOF)

CCAY:

125634803(OTOF)

DCC:	119853524(OTOF)

CPIC:

101940868(OTOF)

TST:	117875554(OTOF)

CABI:

116835647(OTOF)

MRV:	120402031(OTOF)

ACS:

100558712

ASAO:

132761700(OTOF)

PVT:	110089592(OTOF)

SUND:

121929589

PBI:	103051407(OTOF)

PMUR:

107289054(OTOF)

CTIG:

120309120(OTOF)

TSR:	106551857(OTOF)

PGUT:

117667678(OTOF)

APRI:

131189000(OTOF)

PTEX:

113446320(OTOF)

NSS:	113414520(OTOF)

VKO:	123033618(OTOF)

PMUA:

114593441(OTOF)

PRAF:

128411493(OTOF)

ZVI:	118082712(OTOF)

HCG:	128324805(OTOF)

GJA:	107126276(OTOF)

STOW:

125444173(OTOF)

EMC:	129328071(OTOF)

XLA:	108717273(otof.L) 108718319(otof.S)

XTR:	100125064(otof)

NPR:	108800175(OTOF)

RTEM:

120936205(OTOF)

BBUF:

120997138(OTOF)

BGAR:

122934130(OTOF)

PWL:	138295409(OTOF)

MUO:	115467015(OTOF)

GSH:	117357540(OTOF)

DRE:	100331283(otofb) 557476(otofa)

SRX:	107723281 107726465 107732639 107752720

SANH:

107693216 107696112 107701524 107702229

SGH:	107549123(otof) 107565006 107589784 107602556

CCAR:

109074456 109090005 109112642 109112648

CAUA:

113060422 113062825 113116947 113120786

CGIB:

127938468 127975799 127983447 128031394

PTET:

122324926(otofa) 122361562

LROH:

127179768 127182991(otofa)

OMC:	131523001 131526791(otofa)

PPRM:

120479085 120494303(otofa)

RKG:	130075464(otofa) 130076707

MAMB:

125268288 125278074(otofa)

CIDE:

127498036 127502858

CERY:

137006126 137018816(otofa)

MASI:

127410925 127415628 127455346 127456703

TROS:

130560050 130565617(otofa)

TDW:	130434977(otofa) 130436439

MANU:

129417752 129429352(otofa)

PDAB:

135738061 135738738 135748979 135778297

IPU:	108258004(otofa) 108269528

IFU:	128600862(otofa) 128612966

PHYP:

113532001 113538567

SMEO:

124377383(otofa) 124390093

TFD:	113655687(otofa) 113659321

TVC:	132843205(otofa) 132852007

CGAR:

128515158(otofa) 128535633

NGRA:

132883880(otofa) 132893959

TRN:	134320094(otofa) 134325821

AMEX:

103024701 103039766(otofa)

CMAO:

118815608(otofa) 118823961

EEE:	113570554(otof) 113572686

CHAR:

105895720 105909573(otofa)

SPIL:

134067981 134098560(otofa)

TRU:	101070078 101076793

TFS:	130516607(otofa) 130539938

TNG:	GSTEN00023104G001 GSTEN00035728G001

LCO:	104922546 104938731

NCC:	104966098(otof)

TBEN:

117492761(otofa)

CGOB:

115027156 115028991

PGEO:

117439897(otofa)

GACU:

117549042 117555819(otofa)

EMAC:

134877156(otofa) 134881521

ELY:	117266611 117270759(otofa)

EFO:	125896577(otofa) 125901050

PLEP:

121953387 121955578(otofa)

SLUC:

116057532 116066199(otofa)

ECRA:

117936163 117961474(otofa)

ESP:	116670329 116706030(otof)

PFLV:

114546382 114573155(otof)

GAT:	120808439(otofa) 120833257

PPUG:

119194949(otofa) 119227712

AFB:	129103794 129106901(otofa)

CLUM:

117727326(otofa) 117751424

PSWI:

130201360 130202731(otofa)

CANA:

137785412(otofa) 137787445

CVE:	137880276 137882322(otofa)

MSAM:

119909157(otofa) 119910495

SCHU:

122861890 122863161(otofa)

CUD:	121520932(otofa) 121525839

SPUL:

138585427(otofa) 138590894

LMIX:

132984915(otofa) 132993484

ALAT:

119005210 119012316(otofa)

ASTR:

137610603 137613533(otofa)

MZE:	101464447 101481419(otof)

ONL:	100710657 102075960(otof)

OAU:	116310767(otofa) 116318129

OLA:	101155482 101160130

OML:	112142306 112157756(otofa)

CSAI:

133418680(otofa) 133462199

XMA:	102218789 102219633(otof)

XCO:	114134831 114158755

XHE:	116708819 116734446

PRET:

103457483 103458372(otof)

PFOR:

103134535 103134562 103148355

PLAI:

106941405 106961281 106961474

PMEI:

106904568 106908951 106921908

GAF:	122825817(otofa) 122845956

PPRL:

129352430(otofa) 129377432

CVG:	107081396 107098345

CTUL:

119781258(otofa) 119792808

GMU:	124855551 124882258(otofa)

NFU:	107377626 107392000(otof)

KMR:	108233467(otofa) 108239095

ALIM:

106518636(otof) 106531053

NWH:	119418561(otofa) 119427258

AOCE:

111566490 111574216(otofa)

EJA:	138203359(otofa) 138205162

BFRE:

138628524 138633737(otofa)

MCEP:

124999321(otofa) 125023130

CSEM:

103380349(otof) 103380976

POV:	109636186 109642304

SSEN:

122782667 122783860(otofa)

SSOE:

131443728(otofa) 131444594

HHIP:

117756445 117758120(otofa)

HSP:	118099933(otofa) 118115885

PPLT:

128451481 128460370(otofa)

SMAU:

118286696 118290113(otofa)

LCF:	108883122 108902023

SDU:	111225347 111236804(otof)

SLAL:

111658321 111665816(otof)

XGL:	120788856(otofa) 120795244

HCQ:	109513246 109528174

SSCV:

125980477 125990343(otofa)

SBIA:

133496192(otofa) 133513574

PEE:	133412531 133416632(otofa)

PTAO:

133468293(otofa) 133488254

BPEC:

110159977 110162755

ENY:	140360928(otofa) 140369882

MALB:

109952845 109964567

BSPL:

114848697 114849671(otofa)

SJO:	128374871 128376843(otofa)

SSCO:

133997963(otofa) 134001056

GMH:	115534651(otof) 115543881

SASA:

106571765(otof) 106603637 106611328

STRU:

115162009 115172259 115174464 115175094

OTW:	112217802(otofa) 112232964 112255797 112262439

OMY:	110498696 110504237 110522432 110530908

OGO:	123991013 123995267 124001426 124046973

ONE:	115108014(otof) 115118250 115138844 115145933

OKI:	109866151 109894801 109900988(otof) 109904301

OKE:	118361833 118369119 118386621 118397707

OMM:	135505729 135507456 135526898 135557782

OCLA:

139374189 139383375 139407283 139415665

SALP:

111954555 111963071 111963077 111973302

SNH:	120019539 120023017 120024315 120060066

CCLU:

121538933 121544253 121548745 121552294(otofa)

ELS:	105015449 105030558

OEP:	134024537(otofa) 134026602

SFM:	108920081 108921091

PKI:	111841127 111857938

AANG:

118223114 118230688(otofa)

AROT:

135254232 135258058(otofa)

CCOG:

133126188 133128465(otofa)

LOC:	102693398(otof)

PSPA:

121315571 121317477

ARUT:

117402240 117411175

PSEX:

120525741(otofa)

LCM:	102360804(OTOF) 102363059

CMK:	103183133(otofa)

RTP:	109938484(otofa)

CPLA:

122540472(otofa)

HOC:	132834887(otofa)

LERI:

129697157(otofa)

PMRN:

116942631(OTOF) 116945254 116945255

LRJ:	133349209(OTOF) 133353377 133353402

BFO:

BBEL:

CIN:

SCLV:

SPU:

AJJ:

APLC:

AFIL:

SKO:	100329046(Otof)

PFLL:

139132862 139132875

DME:	Dmel_CG5747(mfr)

DER:

6545480

DSE:

6604950

DSI:	Dsimw501_GD12956(Dsim_GD12956)

DYA:	Dyak_GE21275

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI12402

DAZ:

DNV:

DHE:

CCAT:

BOD:	106617046 106619923

BDR:	105230084 105231372

RZE:

108358124

AOQ:	129239460 129242522

ALUD:

128858223 128861676

TDA:	119670147 119683493

MDE:	101893069 101895685

SCAC:

106081311 106092824

LCQ:	111678977 111680352

LSQ:

119609532

CVJ:	135954068(mfr) 135957467

GFS:	119633122 119644955

ECOE:

129944220 129948519

CLON:

129605238 129608952

HIS:

119657361

AGA:	1271860 1275097

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:	110674827 110676122 5565414

AALB:

109407443 109416559 109422096 109428456 115263139

ASUA:

134207708 134211004

CQU:	CpipJ_CPIJ010863

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:	410318 724747

ACER:

ALAB:

ADR:

AFLR:

BIM:	100744963 100748889

BBIF:

117206260 117211858

BVK:	117233079 117233179

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:	122535607 122536045

CCAL:

108622719 108631584

OBB:	114878963 114881269

OLG:	117602068 117609906

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105149641 105152109

ACEP:

105619026 105621655

PBAR:

105425806 105434176

VEM:	105560462 105567530

COBS:

139101594 139111674

TLN:	139818555 139822250

HST:	105184228 105189331

DQU:	106740772 106748081

CFO:	105257499 112639332

FEX:	115238629 115246338

PMEC:

138934414 138936896

LHU:	105670639 105673832

PGC:	109855400 109860002

OBO:	105275662 109610987

PCF:	106790364 106792579

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

LHT:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:	107220924 107228236

NVG:

124299157

AROA:

105694077 125500697

TCA:	657013 658785

TMOL:

138131338 138132910

DPA:	109544744 109544897

ESIM:

136411950 136418168

EFOR:

136340971 136346138(mfr)

SOY:	115878496 115889719

AGRG:

ATD:

CSET:

HAXR:

AGB:	108907312 108909875

LDC:

111518193

DVV:	114337495 126890248

NVL:	108558676 108566266

DCOR:

135793983 135802261

APLN:

108744296

PPYR:

116174614 116174662 116179484

BMOR:

101743144 101743859

BMAN:

114246306

MSEX:

115439939 115445035

DPL:	KGM_203021

MJU:	123879781 123880142

NIQ:

126780582

VCD:	124543385 124543398

MCIX:

123668472

PMAC:

106716998 106719925

PPOT:

106108339 106110602

PXU:	106126170 106126476

BPHI:

PRAP:

PBX:

PNAP:

ZCE:	119835783 119835878

CCRC:

123705334

LSIN:

126978888

AAGE:

121738416

HAW:	110372475 110373002

HZE:	124644822 124645318

TNL:	113495737 113508409

SLIU:

111361106 111361113

OFU:

114353094

ONU:	135087155 135087196

ATRA:

106133811 106133888

GMW:	113509187 113520180

PXY:	105381351 105390319

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103512257 113472744

CLEC:

106664295 106674042

HHAL:

106685085 106687824

NLU:	111049113 111050068

MQU:	128994040 128995786

PHU:	Phum_PHUM202900 Phum_PHUM484780

FOC:

113209701

TPAL:

117640477

ZNE:	110835822 110836328

CSEC:

PAME:

SGRE:

BROR:

IEL:	124158845 124170976

HAMR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:	121121646(mfr)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

LPOL:

HRO:	HELRODRAFT_114638

LGI:	LOTGIDRAFT_125029

PVUL:

PCAN:

LSAX:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106150648 106180923

SMM:	Smp_163750

OVI:	T265_08582

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100204322 100205085

HSY:	130622730 130647359 130654128 130655648

RES:	135688753 135689123 135689133

TAD:	TRIADDRAFT_27805

PIF:	PITG_02021

PSOJ:

PHYSODRAFT_490672

SPAR:

SPRG_06649

» show all

Reference

PMID:18772196

Authors

Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N

Title

Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.

Journal

Hum Mol Genet 17:3814-21 (2008)
DOI:10.1093/hmg/ddn279

Sequence

[mmu:83762]

Reference

PMID:25122888

Authors

Vincent PF, Bouleau Y, Safieddine S, Petit C, Dulon D

Title

Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.

Journal

J Neurosci 34:10853-69 (2014)
DOI:10.1523/JNEUROSCI.0947-14.2014

Sequence

[mmu:83762]

LinkDB

DBGET integrated database retrieval system