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ENTRY	nt06318
Name	CaSR-PTH signaling
Category	Pathway view; Endocrine system
Pathway	hsa04928 Parathyroid hormone synthesis, secretion and action
Disease	H00246 Hyperparathyroidism H01862 Hypoparathyroidism
Display	drug-target relation   disease type

D5,D6,D7,D8,D9  |                     N00291    Ca2+ → CASR → GNAQ → PLCB → IP3 → Ca2+ ⊣ PTH     Hyperparathyroidism     CASR*             D1,D2,D3,D4  |                 N00288        PTH → PTH1R → GNAS → ADCY → cAMP → PKA     Pseudohypoparathyroidism             GNAS* N00293    GCM2 ⇒ PTH     Hyperparathyroidism GCM2*↗     Hypoparathyroidism GCM2*     Hypoparathyroidism     PTH*

		Disease name	Disease category
Hyperparathyroidism	H00246	Primary hyperparathyroidism	Endocrine and metabolic disease
	H02030	Neonatal hyperparathyroidism	Endocrine and metabolic disease
Pseudohypoparathyroidism	H00244	Pseudohypoparathyroidism	Endocrine and metabolic disease
Hypoparathyroidism	H01862	Hypoparathyroidism	Endocrine and metabolic disease

		Drug name
D1	D03358	Teriparatide acetate (JAN)
D2	D05364	Parathyroid hormone (human) (USAN)
D3	D06078	Teriparatide (USP/INN)
D4	D12395	Palopegteriparatide (JAN/USAN/INN)
D5	D03505	Cinacalcet hydrochloride (JAN/USAN)
D6	D10677	Etelcalcetide hydrochloride (JAN/USAN)
D7	D11063	Evocalcet (JAN/INN)
D8	D11564	Upacicalcet sodium hydrate (JAN)
D9	D12917	Upacicalcet sodium (USAN)