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ENTRY	nt06036
Name	Lysine degradation
Category	Pathway view; Amino acid metabolism
Pathway	hsa00310 Lysine degradation hsa00760 Nicotinate and nicotinamide metabolism hsa00380 Tryptophan metabolism
Module	hsa_M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA hsa_M00912 NAD biosynthesis, tryptophan => quinolinate => NAD
Display	drug-target relation   disease type

N01685    Lys+NADPH − AASS ⇉ ALDH7A1 ⇉ AADAT → 2-OA     Hyperlysinemia/Saccharopinuria Lys↗   AASS*     PDE         ALDH7A1* N01724    NAD+ − (NADK2,NADK) ⇉ NADP+     DECR     NADK2*   N01686    2-OA+Lipoyl-E2 − DHTKD1 ⇉ DLST → Glutaryl-CoA+Dihyd..     AAKAD     DHTKD1* N01687    Glutaryl-CoA − GCDH → Crotonoyl-CoA     GA1 Glutaryl-CoA↗   GCDH*   N01723    Trp − (TDO2,IDO1/2) ⇉ AFMID → Kyn − KMO ⇉ KYNU ⇉ HAAO ⇉ QPRT ⇉ NMNAT ⇉ NADSYN1 → NAD+     Hydroxykynureninuria/VCRL2                     KYNU*     VCRL1                         HAAO*     VCRL3                                     NADSYN1*

		Disease name	Disease category
Hyperlysinemia/Saccharopinuria	H00188	Hyperlysinemia	Inherited metabolic disorder
	H01242	Saccharopinuria	Inherited metabolic disorder
PDE	H01247	Pyridoxine-dependent epilepsy	Nervous system disease
DECR	H01929	2,4-Dienoyl-CoA reductase deficiency	Inherited metabolic disorder, Mitochondrial disease
AAKAD	H02644	Alpha-aminoadipic and alpha-ketoadipic aciduria	Inherited metabolic disorder
GA1	H00178	Glutaric acidemia	Inherited metabolic disorder
Hydroxykynureninuria/VCRL2	H01583	Hydroxykynureninuria	Inherited metabolic disorder
	H02087	Vertebral, cardiac, renal, and limb defects syndrome	Inherited metabolic disorder
VCRL1	H02087	Vertebral, cardiac, renal, and limb defects syndrome	Inherited metabolic disorder
VCRL3	H02087	Vertebral, cardiac, renal, and limb defects syndrome	Inherited metabolic disorder