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ENTRY	nt06552
Name	Integrated stress response (ISR) signaling pathway
Category	Pathway view; Cellular processes
Pathway	hsa04156 Integrated stress response (ISR) signaling pathway
Display	drug-target relation   disease type

N02046            eIF2+GDP − EIF2B → eIF2+GTP = Met-tRNAi     MEHMO         EIF2S3*     VWM1             EIF2B1*     VWM2             EIF2B2*     VWM3             EIF2B3*     VWM4             EIF2B4*     VWM5             EIF2B5*   N02047        (EIF2AK1,EIF2AK2,E.. − (EIF2S1+Pi) ⊣ EIF2B N02048        (EIF2AK1,EIF2AK2,E.. − (EIF2S1+Pi)+(EIF2S.. → (EIF2S1+Pi+EIF2S2+..     LEMSPAD     EIF2AK1*     DYT33/LEUDEN     EIF2AK2*     WRS     EIF2AK3*     PVOD2     EIF2AK4*   N02049    (PP1C+PPP1R15A,PPP.. ⊣ (EIF2AK1,EIF2AK2,E..     MSSGM2 PPP1R15B*   N02050        OMA1 → DELE1 → EIF2AK1 → EIF2S1 → ATF4 ⇒ DDIT3 N02051    (CHCHD2+CHCHD10) ⊣ OMA1     PARK22 CHCHD2*     FTDALS2/IMMD CHCHD10* N02052        LONP1 ⊣ DELE1     CODAS     LONP1*   N02053    EIF2AK1,EIF2AK2,EI.. → EIF2S1 → ATF4,ATF5 ⇒ LONP1,HSPA9,HSPD1     SIDBA4/EVPLS             HSPA9*     SPG13/HLD4             HSPD1*

		Disease name	Disease category
MEHMO	H02195	MEHMO syndrome	Congenital malformation
VWM1	H00869	Leukoencephalopathy with vanishing white matter	Nervous system disease
VWM2	H00869	Leukoencephalopathy with vanishing white matter	Nervous system disease
VWM3	H00869	Leukoencephalopathy with vanishing white matter	Nervous system disease
VWM4	H00869	Leukoencephalopathy with vanishing white matter	Nervous system disease
VWM5	H00869	Leukoencephalopathy with vanishing white matter	Nervous system disease
LEMSPAD	H02457	Developmental delay, leukoencephalopathy, and neurologic decompensation	Nervous system disease
DYT33/LEUDEN	H00831	Primary dystonia	Nervous system disease
	H02457	Developmental delay, leukoencephalopathy, and neurologic decompensation	Nervous system disease
WRS	H00766	Wolcott-Rallison syndrome	Endocrine and metabolic disease
PVOD2	H01866	Pulmonary veno-occlusive disease	Cardiovascular disease
MSSGM2	H01923	Microcephaly, short stature, and impaired glucose metabolism	Congenital malformation
PARK22	H00057	Parkinson disease	Neurodegenerative disease
FTDALS2/IMMD	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
	H03051	Autosomal dominant isolated mitochondrial myopathy	Inherited metabolic disorder
CODAS	H01824	CODAS syndrome	Congenital malformation
SIDBA4/EVPLS	H00982	Sideroblastic anemia	Hematologic disease
	H02343	EVEN-plus syndrome	Congenital malformation
SPG13/HLD4	H00266	Hereditary spastic paraplegia	Nervous system disease
	H00679	Hypomyelinating leukodystrophy	Inherited metabolic disorder