KEGG   PATHWAY: aml04020
Entry
aml04020                    Pathway                                
Name
Calcium signaling pathway - Ailuropoda melanoleuca (giant panda)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
aml04020  Calcium signaling pathway
aml04020

Other DBs
GO: 0019722
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100471755  SLC8A3; sodium/calcium exchanger 3 isoform X2 [KO:K05849]
100474541  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
100469610  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
100472949  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100476768  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100465354  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100484762  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100481445  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109488507  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
100480193  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100478431  ADORA2A; adenosine receptor A2a [KO:K04266]
100464166  ADORA2B; adenosine receptor A2b [KO:K04267]
100471252  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
100474451  ADRB2; beta-2 adrenergic receptor isoform X5 [KO:K04142]
100469495  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
100480500  DRD1; D(1A) dopamine receptor [KO:K04144]
100477987  DRD5; D(1B) dopamine receptor [KO:K05840]
100480755  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
100468962  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
100467594  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
100482203  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100483737  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100464818  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
100473680  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
100469231  neuroendocrine secretory protein 55 [KO:K04632]
100479878  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
100472777  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100473195  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100471164  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100471940  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100466965  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100474121  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100476495  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100465655  PLN; cardiac phospholamban [KO:K05852]
100466949  SLN; sarcolipin [KO:K22642]
117799087  sarcolipin [KO:K22642]
105235795  MRLN; myoregulin [KO:K22643]
100483290  C11H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
105237911  SMIM6; small integral membrane protein 6 [KO:K26468]
100465699  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6 [KO:K05853] [EC:7.2.2.10]
100470716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100465047  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100475216  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100482557  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
100471703  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
100477778  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100480196  ORAI2; protein orai-2 [KO:K16057]
100477490  ORAI3; protein orai-3 [KO:K16058]
100479715  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
100467700  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100468661  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100472835  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100473951  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100466608  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100466242  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
100464603  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100464578  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
100484838  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100469287  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100465687  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100469843  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100466153  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100475562  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100473622  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100474487  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X3 [KO:K05213]
100484451  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100463691  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
100476571  P2RX3; P2X purinoceptor 3 [KO:K05217]
100477528  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
100464947  P2RX5; P2X purinoceptor 5 [KO:K05219]
100471072  P2RX6; P2X purinoceptor 6 [KO:K05221]
100477277  P2RX7; P2X purinoceptor 7 isoform X2 [KO:K05220]
100471044  RYR1; ryanodine receptor 1 [KO:K04961]
100476576  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
100481196  RYR3; ryanodine receptor 3 [KO:K04963]
109489706  TRDN; triadin [KO:K23449]
100481138  CASQ1; calsequestrin-1 [KO:K23468]
100469187  CASQ2; calsequestrin-2 [KO:K23445]
100479314  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X8 [KO:K00476] [EC:1.14.11.16]
100469195  CYSLTR1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
100475060  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X2 [KO:K04323]
100483729  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100479899  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
100482658  alpha-1B adrenergic receptor [KO:K04136]
117801375  alpha-1B adrenergic receptor-like [KO:K04136]
100474572  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100471220  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100474277  EDNRA; endothelin-1 receptor [KO:K04197]
100465526  EDNRB; endothelin receptor type B [KO:K04198]
105240499  F2R; proteinase-activated receptor 1 [KO:K03914]
100479929  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100466868  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100468501  GRPR; gastrin-releasing peptide receptor isoform X3 [KO:K04169]
100471067  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
100483987  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
100466077  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100464098  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
100478534  lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
100479759  NTSR1; neurotensin receptor type 1 [KO:K04211]
100473374  OXTR; LOW QUALITY PROTEIN: oxytocin receptor [KO:K04229]
100484939  AVPR1A; vasopressin V1a receptor [KO:K04226]
100476427  AVPR1B; vasopressin V1b receptor [KO:K04227]
100466170  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100469053  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
105238442  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100480537  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
100465340  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100482893  BDKRB1; B1 bradykinin receptor [KO:K03915]
100482647  BDKRB2; B2 bradykinin receptor [KO:K03916]
100477723  TACR1; substance-P receptor [KO:K04222]
100475693  TACR2; substance-K receptor isoform X1 [KO:K04223]
100476487  TBXA2R; thromboxane A2 receptor [KO:K04264]
100465073  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
109490241  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
100468785  thyrotropin-releasing hormone receptor-like [KO:K04282]
100471458  CCKAR; cholecystokinin receptor type A [KO:K04194]
100476081  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
100468194  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100464853  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100469689  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100463849  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100469944  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
100467733  pro-epidermal growth factor isoform X1 [KO:K04357]
100467724  TGFA; protransforming growth factor alpha isoform X3 [KO:K08774]
100473486  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100475543  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100479872  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100481171  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100463878  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100479986  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
100482817  FGF8; fibroblast growth factor 8 [KO:K04358]
100474108  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100468641  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100467527  FGF20; fibroblast growth factor 20 [KO:K04358]
100479573  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
100464088  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100470803  fibroblast growth factor 3 [KO:K04358]
100471023  FGF6; fibroblast growth factor 6 [KO:K04358]
100473739  FGF9; fibroblast growth factor 9 [KO:K04358]
100466947  FGF16; fibroblast growth factor 16 [KO:K04358]
100475745  FGF10; fibroblast growth factor 10 [KO:K04358]
100481939  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
100470300  FGF19; fibroblast growth factor 19 [KO:K22603]
100478145  FGF21; fibroblast growth factor 21 [KO:K22429]
100472512  FGF23; fibroblast growth factor 23 [KO:K22428]
100482983  VEGFA; vascular endothelial growth factor A [KO:K05448]
100465735  VEGFB; vascular endothelial growth factor B [KO:K16858]
100482213  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100483046  VEGFC; vascular endothelial growth factor C [KO:K05449]
100469695  NGF; beta-nerve growth factor [KO:K02582]
100463560  HGF; hepatocyte growth factor isoform X5 [KO:K05460]
100482601  MST1; hepatocyte growth factor-like protein [KO:K23441]
100469029  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100480029  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100468735  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100470612  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100464991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100472005  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100472630  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100468267  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100481826  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100477678  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100483462  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100478767  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
100484938  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100477127  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
100472259  NTRK3; NT-3 growth factor receptor isoform X2 [KO:K05101] [EC:2.7.10.1]
100480742  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
100473272  MST1R; macrophage-stimulating protein receptor isoform X4 [KO:K05100] [EC:2.7.10.1]
100467317  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100469148  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2 [KO:K05857] [EC:3.1.4.11]
100471021  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
100476035  PLCD1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100480586  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100481994  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100479318  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
100471118  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
100467161  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
100477888  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100471747  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100481326  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100463932  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
100473327  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
100474979  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
100472508  MCOLN2; mucolipin-2 isoform X3 [KO:K04993]
100472258  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
100479407  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
100473787  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
100475721  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100463625  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100465507  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100470763  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100473508  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100464085  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100469507  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100476732  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117799792  ADP/ATP translocase 2-like [KO:K05863]
100481603  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100484935  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
117800158  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
100473401  TNNC2; troponin C, skeletal muscle [KO:K12042]
117800170  troponin C, skeletal muscle [KO:K12042]
100478600  CALML6; calmodulin-like protein 6 [KO:K02183]
100470909  CALM2; calmodulin-2 [KO:K02183]
100484519  calmodulin [KO:K02183]
100484770  calmodulin-like protein 3 [KO:K02183]
100481177  CALM1; calmodulin-1 [KO:K02183]
100472122  CALM3; calmodulin-3 [KO:K02183]
100478732  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117799706  calmodulin-alpha-like [KO:K02183]
100477667  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
100478501  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
100468646  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100479757  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X5 [KO:K07190]
100482884  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
100473453  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100481263  MYLK; myosin light chain kinase, smooth muscle isoform X5 [KO:K00907] [EC:2.7.11.18]
100469244  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100474254  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100471632  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
100477852  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
100465342  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100475467  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
100466256  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5 [KO:K04515] [EC:2.7.11.17]
100474459  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3 [KO:K04515] [EC:2.7.11.17]
100478243  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
100473015  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100477289  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100467653  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474970  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100467683  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100465562  TFEB; transcription factor EB isoform X1 [KO:K15590]
100470861  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100464798  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100477832  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100471691  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100468087  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100470060  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100483990  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
100464920  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100478405  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
100476485  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
100478801  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100471742  ITPKA; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100466758  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100471702  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
100477326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100478007  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100484719  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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PMID:11698232
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Keef KD, Hume JR, Zhong J.
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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Yakel JL.
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
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Reference
PMID:14572802
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Bruce JI, Straub SV, Yule DI.
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Reference
PMID:10331643
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Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
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Reference
PMID:11080247
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Crompton M.
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
aml04010  MAPK signaling pathway
aml04070  Phosphatidylinositol signaling system
aml04210  Apoptosis
aml04720  Long-term potentiation
aml04730  Long-term depression
KO pathway
ko04020   
LinkDB

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