KEGG   PATHWAY: ajm05208
Entry
ajm05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
ajm05208  Chemical carcinogenesis - reactive oxygen species
ajm05208

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119043286  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
119044181  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
119038198  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
119038509  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
119039311  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
119041343  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
119041344  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
119034965  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
119042793  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
119042872  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
119059001  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119059190  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
119059191  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
119059193  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119059228  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
119059627  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
119059706  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
119059742  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
119059743  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
119059745  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
119059996  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
119054553  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
119054555  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
119054565  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
119062912  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
119055852  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
119065408  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
808336  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808337  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808335  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808341  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808338  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808343  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808345  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
119041886  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119062765  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119047858  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial-like [KO:K03942] [EC:7.1.1.2]
119047547  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
119048802  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
119060097  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
119051031  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
119035990  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
119058578  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119035650  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
119065356  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
119052577  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
119047844  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
119060175  NDUFA6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
119059324  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
119058701  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
119046902  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
119046884  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial-like [KO:K03953]
119054863  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
119061047  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
119059248  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
119062380  acyl carrier protein, mitochondrial-like [KO:K03955]
119063810  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
119060482  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
119054709  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
119037973  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
119044477  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
119065520  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
119045182  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
119054436  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
119043023  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
119060007  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
119049700  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
119059659  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
119064637  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
119057225  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-B-like [KO:K03966]
119058250  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
119060282  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
119049214  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934] [EC:7.1.1.2]
119064342  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
119038933  NADH-ubiquinone oxidoreductase 49 kDa subunit-like [KO:K03935] [EC:7.1.1.2]
119052562  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
119064429  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
119049168  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
119052496  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
119043399  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
119043734  probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
119044196  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
119041917  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
119034973  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
119044291  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
119043356  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
119040544  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
119049945  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
119052482  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
119056525  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
119049098  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
119049737  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
808339  CYTB; cytochrome b [KO:K00412]
119054812  cytochrome c1-2, heme protein, mitochondrial [KO:K00413]
119064722  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
119036682  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
119056044  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
119057504  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
119052413  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
119037581  cytochrome b-c1 complex subunit 7 [KO:K00417]
119038585  cytochrome b-c1 complex subunit 7 [KO:K00417]
119037668  cytochrome b-c1 complex subunit 8 [KO:K00418]
119038072  cytochrome b-c1 complex subunit 8-like [KO:K00418]
119055148  cytochrome b-c1 complex subunit 9 [KO:K00419]
119043944  cytochrome b-c1 complex subunit 10 [KO:K00420]
808342  COX3; cytochrome c oxidase subunit III [KO:K02262]
808340  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808333  COX2; cytochrome c oxidase subunit II [KO:K02261]
119047065  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
119047719  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
119046558  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
119053181  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119055996  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
119038030  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
119057477  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119044212  cytochrome c oxidase subunit 6B1 [KO:K02267]
119051314  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
119059934  cytochrome c oxidase subunit 6B2 [KO:K02267]
119054176  cytochrome c oxidase subunit 6B2-like [KO:K02267]
119047669  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119065432  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119050774  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119038600  cytochrome c oxidase subunit 6C [KO:K02268]
119061534  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
119049825  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
119050898  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
119039407  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
119039459  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
119046078  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
119052752  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
119065249  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119045463  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
119063661  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
119038717  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119040325  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119042966  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119052971  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
119056972  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
119044111  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
119061345  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
119055371  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
808334  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
119054530  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
119043527  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119052667  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
119057209  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
119050909  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
119065275  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
119035752  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
119056730  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
808344  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
119034937  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
119055703  37S ribosomal protein MRP1, mitochondrial [KO:K04564] [EC:1.15.1.1]
119037617  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
119038134  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119053810  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
119047138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
119035353  ADP,ATP carrier protein 1, mitochondrial [KO:K05863]
119036890  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
119037676  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
119045737  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
119046880  ADP,ATP carrier protein [KO:K05863]
119062994  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
119050103  ADP/ATP translocase 3-like [KO:K05863]
119056937  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119036390  superoxide dismutase [Cu-Zn] 4A [KO:K04565] [EC:1.15.1.1]
119061029  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
119036439  CAT; catalase [KO:K03781] [EC:1.11.1.6]
119038696  catalase-1 [KO:K03781] [EC:1.11.1.6]
119053339  catalase-like [KO:K03781] [EC:1.11.1.6]
119035501  SLC26A1; sulfate anion transporter 1 isoform X1 [KO:K14700]
119061400  SLC26A2; sulfate transporter [KO:K14701]
119036590  solute carrier family 26 member 6 isoform X1 [KO:K14704]
119056850  SLC26A9; solute carrier family 26 member 9 isoform X1 [KO:K14706]
119046569  LOW QUALITY PROTEIN: cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
119059516  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
119040806  LOW QUALITY PROTEIN: cytochrome P450 2F1 [KO:K07416] [EC:1.14.14.1]
119041322  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
119041329  cytochrome P450 1A1-like [KO:K07408] [EC:1.14.14.1]
119063849  cytochrome P450 1B1 isoform X1 [KO:K07410] [EC:1.14.14.1]
119044442  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
119044629  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
119061772  EPHX3; epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
119056107  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
119039972  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119052197  aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
119052199  aldo-keto reductase family 1 member A1-like [KO:K00002] [EC:1.1.1.2]
119060729  aldo-keto reductase family 1 member A1-like [KO:K00002] [EC:1.1.1.2]
119057712  aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
119061942  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
119035748  carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119062853  AHR; aryl hydrocarbon receptor [KO:K09093]
119062637  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
119043581  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
119047041  cytochrome b-245 light chain isoform X1 [KO:K08009]
119042037  NCF1; neutrophil cytosol factor 1 [KO:K08011]
119049621  NCF2; neutrophil cytosol factor 2 [KO:K08010]
119057431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119057339  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119044937  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
119038260  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119058521  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
119052051  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
119056966  SOS2; son of sevenless homolog 2 [KO:K03099]
119062206  HRAS; GTPase HRas isoform X1 [KO:K02833]
119048987  KRAS; GTPase KRas isoform X1 [KO:K07827]
119041711  NRAS; GTPase NRas [KO:K07828]
119060144  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119044502  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119044815  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
119057101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119063754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119052787  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119061575  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
119057169  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119059334  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119042614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119046845  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119062834  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119060490  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119060539  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050071  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050081  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119051654  JUN; transcription factor AP-1 [KO:K04448]
119049259  FOS; proto-oncogene c-Fos [KO:K04379]
119052227  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119053288  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119046830  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119041500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119051762  rho-related BTB domain-containing protein 1-like [KO:K04392]
119041006  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119059362  FOXO3; forkhead box protein O3 [KO:K09408]
119045448  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119065325  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
119057730  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119062929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119050282  RELA; transcription factor p65 [KO:K04735]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119041430  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
119064424  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
119053964  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
119040448  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
119063248  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119059032  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
119049579  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
119044978  LOW QUALITY PROTEIN: serine/threonine-protein kinase D3-like [KO:K06070] [EC:2.7.11.13]
119062510  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
119063835  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
119056632  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
119064798  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119043204  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
119043442  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
119039312  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
119061562  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119039594  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
119034693  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
119055590  VEGFA; vascular endothelial growth factor A [KO:K05448]
119055679  KEAP1; kelch-like ECH-associated protein 1 isoform X1 [KO:K10456]
119037735  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
119060410  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
ajm00190  Oxidative phosphorylation
ajm00980  Metabolism of xenobiotics by cytochrome P450
ajm04010  MAPK signaling pathway
ajm04064  NF-kappa B signaling pathway
ajm04066  HIF-1 signaling pathway
ajm04151  PI3K-Akt signaling pathway
ajm04370  VEGF signaling pathway
ajm05207  Chemical carcinogenesis - receptor activation
ajm05211  Renal cell carcinoma
ajm05215  Prostate cancer
ajm05219  Bladder cancer
ajm05221  Acute myeloid leukemia
ajm05222  Small cell lung cancer
ajm05223  Non-small cell lung cancer
ajm05224  Breast cancer
ajm05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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