KEGG   PATHWAY: biu04024
Entry
biu04024                    Pathway                                
Name
cAMP signaling pathway - Bos indicus (zebu cattle)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
biu04024  cAMP signaling pathway
biu04024

Other DBs
GO: 0019933
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109563671  VIP peptides [KO:K05264]
109563673  VIP; VIP peptides [KO:K05264]
109568302  corticoliberin [KO:K05256]
109568305  CRH; corticoliberin [KO:K05256]
109563646  CGA; glycoprotein hormones alpha chain [KO:K08522]
109571973  lutropin subunit beta-like [KO:K08521]
109573026  lutropin subunit beta [KO:K08521]
109554578  GPHA2; glycoprotein hormone alpha-2 isoform X1 [KO:K25483]
109564582  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
109555886  TSHB; thyrotropin subunit beta [KO:K05251]
109566326  POMC; pro-opiomelanocortin [KO:K05228]
109576469  GCG; glucagon isoform X1 [KO:K05259]
109573627  GIP; gastric inhibitory polypeptide [KO:K05258]
109569281  follitropin subunit beta [KO:K05250]
109569290  follitropin subunit beta-like [KO:K05250]
109570145  NPPA; natriuretic peptides A [KO:K12334]
109578023  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
109553237  ADRB1; beta-1 adrenergic receptor [KO:K04141]
109562177  ADRB2; beta-2 adrenergic receptor [KO:K04142]
109564446  DRD1; D(1A) dopamine receptor [KO:K04144]
109570969  ADORA2A; adenosine receptor A2a [KO:K04266]
109562176  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
109574407  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
109564679  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
109557471  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
109558052  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
109573320  CRHR1; LOW QUALITY PROTEIN: corticotropin-releasing factor receptor 1 [KO:K04578]
109557474  CRHR2; corticotropin-releasing factor receptor 2 [KO:K04579]
109565541  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
109565398  TSHR; thyrotropin receptor [KO:K04249]
109577760  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
109576566  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
109573073  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
109565738  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
109554550  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
109567291  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
109567292  neuroendocrine secretory protein 55 [KO:K04632]
109577403  EDN1; endothelin-1 [KO:K16366]
109557106  EDN2; endothelin-2 [KO:K16367]
109567284  EDN3; endothelin-3 [KO:K05227]
109564221  SST; somatostatin [KO:K05237]
109558110  NPY; pro-neuropeptide Y [KO:K05232]
109575799  GHRL; appetite-regulating hormone [KO:K05254]
109567741  OXT; oxytocin-neurophysin 1 [KO:K05243]
109563893  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
109574780  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
109563647  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
109563717  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
109577134  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
109554719  CHRM1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 [KO:K04129]
109557673  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
109569207  DRD2; D(2) dopamine receptor [KO:K04145]
109562526  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
109577195  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
109571433  EDNRA; endothelin-1 receptor [KO:K04197]
109575218  SSTR1; somatostatin receptor type 1 [KO:K04217]
109573447  SSTR2; somatostatin receptor type 2 [KO:K04218]
109578277  SSTR5; somatostatin receptor type 5 [KO:K04221]
109571562  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
109571509  hydroxycarboxylic acid receptor 2-like [KO:K08402]
109572374  free fatty acid receptor 2-like [KO:K04328]
109571696  LOW QUALITY PROTEIN: free fatty acid receptor 2-like [KO:K04328]
109559158  SUCNR1; succinate receptor 1 [KO:K10042]
109556168  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
109576336  OXTR; oxytocin receptor [KO:K04229]
109558036  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
109557337  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109576257  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109555970  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
109557525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109574822  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109566330  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
109564199  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
109555842  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
109559159  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
109572478  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109568647  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
109578364  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
109577377  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
109577577  ADCY10; LOW QUALITY PROTEIN: adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
109560448  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
109555004  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
109565820  CNGA3; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
109569214  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
109572130  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
109568317  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
109565417  CALM1; calmodulin [KO:K02183]
109575003  calmodulin-alpha-like [KO:K02183]
109566056  CALM2; calmodulin [KO:K02183]
109568081  calmodulin-like [KO:K02183]
109570679  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
109572535  CALM3; calmodulin isoform X1 [KO:K02183]
109564712  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
109553698  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109560236  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109557541  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109562200  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
109563876  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
109577455  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
109563873  POPDC3; popeye domain-containing protein 3 [KO:K26207]
109570750  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
109561057  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
109564751  HCN4; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
109566910  multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
109567080  multidrug resistance-associated protein 4-like [KO:K05673]
109567081  multidrug resistance-associated protein 4-like [KO:K05673]
109567083  multidrug resistance-associated protein 4-like [KO:K05673]
109567082  multidrug resistance-associated protein 4-like [KO:K05673]
109559177  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
109566435  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
109572222  RRAS; ras-related protein R-Ras [KO:K07829]
109569777  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109574235  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
109558091  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
109553155  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
109561331  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109560650  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109553773  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109555931  RAP1A; ras-related protein Rap-1A [KO:K04353]
109559248  RAP1B; ras-related protein Rap-1b [KO:K07836]
109562052  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
109565687  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
109560955  VAV1; proto-oncogene vav [KO:K05730]
109556793  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109559531  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109574290  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109554525  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109561086  ARAP3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
109576171  RHOA; transforming protein RhoA [KO:K04513]
109564121  AFDN; afadin isoform X1 [KO:K05702]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109556345  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109557698  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109556827  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109561498  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109574383  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
109554414  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109571193  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
109566263  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109570093  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109554418  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109557676  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
109563018  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
109569868  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
109561750  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
109557489  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
109578349  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
109559852  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109569212  BDNF; brain-derived neurotrophic factor [KO:K04355]
109565363  FOS; proto-oncogene c-Fos [KO:K04379]
109556235  JUN; transcription factor AP-1 [KO:K04448]
109557558  GLI3; transcriptional activator GLI3 [KO:K06230]
109559320  GLI1; zinc finger protein GLI1 [KO:K16797]
109563237  PTCH1; protein patched homolog 1 [KO:K06225]
109570862  HHIP; hedgehog-interacting protein [KO:K06231]
109575581  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109554392  RELA; transcription factor p65 [KO:K04735]
109561802  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
109559910  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
109573351  ACOX1; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
109560748  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
109577750  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109564649  F2R; proteinase-activated receptor 1 [KO:K03914]
109554386  BAD; bcl2-associated agonist of cell death [KO:K02158]
109572731  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
109577829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109566382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109558936  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109567416  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109572857  TNNI3; troponin I, cardiac muscle [KO:K12044]
109563783  PLN; cardiac phospholamban [KO:K05852]
109574167  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109578141  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
109571032  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
109553606  RYR2; ryanodine receptor 2 [KO:K04962]
109578088  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
109559635  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
109573357  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
109571774  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
109563305  GRIN3A; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
109561061  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
109562229  GRIA1; LOW QUALITY PROTEIN: glutamate receptor 1 [KO:K05197]
109571560  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
109555352  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
109568760  GRIA4; glutamate receptor 4 [KO:K05200]
109557891  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
109578704  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
109578722  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
109555876  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
109571737  ATP1A3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
109555144  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
109574423  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
109570324  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
109559642  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
109569778  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
109572406  FXYD1; phospholemman isoform X1 [KO:K13360]
109573208  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
109571127  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
109555546  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
109558967  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
109570406  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
109576121  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
109558615  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
109576190  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109554975  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109559606  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
109569608  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
109561414  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
109574792  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
109561589  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
109556192  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
109564109  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
biu00071  Fatty acid degradation
biu04015  Rap1 signaling pathway
biu04020  Calcium signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04210  Apoptosis
biu04260  Cardiac muscle contraction
biu04340  Hedgehog signaling pathway
biu04720  Long-term potentiation
biu04740  Olfactory transduction
biu04972  Pancreatic secretion
biu04976  Bile secretion
KO pathway
ko04024   
LinkDB

DBGET integrated database retrieval system