Entry
Name
Axon guidance - Bos indicus (zebu cattle)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Bos indicus (zebu cattle) [GN:
biu ]
Gene
109572707 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
109563107 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109553732 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109560300 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109567554 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
109572084 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
109564198 NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
109569536 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
109555912 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
109557337 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
109576257 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
109555970 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
109576345 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
109559280 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
109570436 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
109563152 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
109553698 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109560236 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109557541 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109559805 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109570415 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109557823 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
109574805 PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
109561418 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
109556345 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
109572619 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound
Reference
Authors
Guan KL, Rao Y.
Title
Signalling mechanisms mediating neuronal responses to guidance cues.
Journal
Reference
Authors
Govek EE, Newey SE, Van Aelst L.
Title
The role of the Rho GTPases in neuronal development.
Journal
Reference
Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal
Reference
Authors
Negishi M, Oinuma I, Katoh H.
Title
Plexins: axon guidance and signal transduction.
Journal
Reference
Authors
Huot J.
Title
Ephrin signaling in axon guidance.
Journal
Reference
Authors
Patel BN, Van Vactor DL.
Title
Axon guidance: the cytoplasmic tail.
Journal
Reference
Authors
Yu TW, Bargmann CI.
Title
Dynamic regulation of axon guidance.
Journal
Reference
Authors
Dickson BJ.
Title
Molecular mechanisms of axon guidance.
Journal
Reference
Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal
Reference
Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal
Reference
Authors
Fujita Y, Yamashita T
Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal
Reference
Authors
Yamashita T, Mueller BK, Hata K
Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal
Reference
Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal
Related pathway
biu04060 Cytokine-cytokine receptor interaction
biu04810 Regulation of actin cytoskeleton
KO pathway
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