KEGG   PATHWAY: clud05205
Entry
clud05205                   Pathway                                
Name
Proteoglycans in cancer - Canis lupus dingo (dingo)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
clud05205  Proteoglycans in cancer
clud05205

Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112663469  CD44; CD44 antigen isoform X2 [KO:K06256]
112673919  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112677440  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
112663195  CTTN; src substrate cortactin isoform X4 [KO:K06106]
112655065  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
112672798  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112677396  VAV2; guanine nucleotide exchange factor VAV2 isoform X8 [KO:K05730]
112640748  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
112666384  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112665533  KRAS; GTPase KRas isoform X1 [KO:K07827]
112664166  NRAS; GTPase NRas [KO:K07828]
112645140  RRAS; ras-related protein R-Ras [KO:K07829]
112667665  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
112660985  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
112650991  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112673245  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112666294  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112669083  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
112646333  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
112653075  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
112659940  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112672066  cell division control protein 42 homolog [KO:K04393]
112660852  cell division control protein 42 homolog [KO:K04393]
112675684  cell division control protein 42 homolog [KO:K04393]
112673250  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112644313  ESR1; estrogen receptor isoform X2 [KO:K08550]
112663184  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112646354  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
112672928  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112653534  actin, cytoplasmic 2-like [KO:K05692]
112668365  FLNA; filamin-A isoform X1 [KO:K04437]
112642133  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112661908  TIAM1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
112645406  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330]
112665784  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
112651615  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
112647981  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
112664826  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
112655384  ANK1; LOW QUALITY PROTEIN: ankyrin-1 [KO:K10380]
112671683  ANK2; LOW QUALITY PROTEIN: ankyrin-2 [KO:K09255]
112651919  ANK3; ankyrin-3 isoform X11 [KO:K09259]
112669327  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112660000  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
112659369  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112664593  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112676539  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112654323  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
112667052  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
112645002  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
112671185  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
112672092  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
112662581  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112665544  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112641421  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
112671686  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112650738  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
112651229  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112651948  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
112675319  NANOG; homeobox protein NANOG [KO:K10164]
112652921  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
112652850  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
112654961  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112669997  TWIST2; twist-related protein 2 isoform X1 [KO:K09069]
112670536  TWIST1; twist-related protein 1 [KO:K09069]
112668145  HOXD10; homeobox protein Hox-D10 [KO:K09295]
112654880  DCN; decorin [KO:K04660]
112654388  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
112653816  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112678102  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112640520  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112655510  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112659290  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
112667199  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
112650443  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
118351175  40S ribosomal protein S6-like [KO:K02991]
112645871  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
118354148  40S ribosomal protein S6-like [KO:K02991]
112647577  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
112654846  40S ribosomal protein S6-like [KO:K02991]
112666468  40S ribosomal protein S6-like [KO:K02991]
112677796  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
112661500  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112670793  CAV1; caveolin-1 isoform X1 [KO:K06278]
112670794  CAV2; caveolin-2 isoform X1 [KO:K12958]
112662331  CAV3; caveolin-3 [KO:K12959]
112678050  CD63; CD63 antigen [KO:K06497]
112641497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112675231  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112645426  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
112654591  TLR2; toll-like receptor 2 isoform X2 [KO:K10159]
112650004  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112672330  PDCD4; programmed cell death protein 4 [KO:K16865]
112641287  TNF; tumor necrosis factor [KO:K03156]
112651834  IL12B; interleukin-12 subunit beta [KO:K05425]
112678033  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112656400  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
112662261  MYC; myc proto-oncogene protein [KO:K04377]
112668716  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112656912  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
112640441  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
112641644  VEGFA; vascular endothelial growth factor A [KO:K05448]
112652118  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112670796  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
112671204  CBL; E3 ubiquitin-protein ligase CBL isoform X2 [KO:K04707] [EC:2.3.2.27]
112668945  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
112676140  THBS1; thrombospondin-1 [KO:K16857]
112659990  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
112674054  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
112654548  LUM; lumican [KO:K08122]
112648603  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112656223  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
112677878  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112647438  TP53; cellular tumor antigen p53 [KO:K04451]
112643136  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
112647773  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112646173  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
112672165  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
112664761  SDC1; syndecan-1 isoform X1 [KO:K06257]
112651515  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
112645363  PLAUR; urokinase plasminogen activator surface receptor [KO:K03985]
112674906  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112655086  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
112651978  ITGA2; integrin alpha-2 [KO:K06481]
112679018  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
112677673  VTN; vitronectin [KO:K06251]
112668239  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
112652894  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
112656719  FN1; fibronectin isoform X1 [KO:K05717]
112676939  ITGB5; integrin beta-5 [KO:K06588]
112661349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112678279  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
112674955  FZD1; frizzled-1 [KO:K02432]
112656639  FZD7; frizzled-7 [KO:K02432]
112655297  FZD2; frizzled-2 [KO:K02235]
112669675  FZD3; frizzled-3 isoform X1 [KO:K02329]
112642049  FZD4; frizzled-4 [KO:K02354]
112678994  FZD8; frizzled-8 [KO:K02375]
112656460  FZD5; frizzled-5 [KO:K02375]
112662097  FZD6; frizzled-6 isoform X1 [KO:K02376]
112646159  FZD9; frizzled-9 [KO:K02842]
112676414  FZD10; frizzled-10 [KO:K02842]
112667148  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
112650672  SDC2; syndecan-2 [KO:K16336]
112644369  EZR; ezrin isoform X1 [KO:K08007]
112671371  RDX; radixin isoform X1 [KO:K05762]
112671781  MSN; moesin isoform X1 [KO:K05763]
112674016  SDC4; syndecan-4 [KO:K16338]
112642713  FGF2; fibroblast growth factor 2 isoform X2 [KO:K18497]
112649669  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112677869  FRS2; fibroblast growth factor receptor substrate 2 isoform X1 [KO:K12461]
112676579  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112647029  AGRN; agrin isoform X15 [KO:K07293] [EC:3.1.3.48]
112657995  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112664493  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112673956  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
112646723  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112652873  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
112640230  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112645036  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112640423  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
112676659  PXN; paxillin isoform X5 [KO:K05760]
112662017  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112658975  HBEGF; proheparin-binding EGF-like growth factor isoform X1 [KO:K08523]
112670018  GPC1; glypican-1 isoform X1 [KO:K08107]
112663224  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
112649226  GPC3; glypican-3 [KO:K08109]
112670801  WNT2; protein Wnt-2 isoform X2 [KO:K00182]
112663902  WNT2B; protein Wnt-2b [KO:K00182]
112652965  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112665303  WNT3A; protein Wnt-3a [KO:K00312]
112660019  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112668992  WNT5B; protein Wnt-5b [KO:K00444]
112665934  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112656503  WNT6; protein Wnt-6 [KO:K00445]
112660989  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
112666027  WNT7B; protein Wnt-7b isoform X5 [KO:K00572]
112672198  WNT8B; protein Wnt-8b [KO:K00714]
112650067  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
112652984  WNT9B; protein Wnt-9b [KO:K01064]
112665302  WNT9A; protein Wnt-9a [KO:K01064]
112656502  WNT10A; protein Wnt-10a [KO:K01357]
112678278  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
112642157  WNT11; protein Wnt-11 [KO:K01384]
112678075  WNT16; protein Wnt-16 [KO:K01558]
112663058  SHH; sonic hedgehog protein [KO:K11988]
112656444  IHH; indian hedgehog protein [KO:K11989]
112644598  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
112675071  SMO; smoothened homolog isoform X1 [KO:K06226]
112660444  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
112643829  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
112644575  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
112673255  procathepsin L [KO:K01365] [EC:3.4.22.15]
112666620  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112640987  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112641479  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112641481  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112665560  MAPK11; mitogen-activated protein kinase 11 isoform X3 [KO:K04441] [EC:2.7.11.24]
112665622  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
112671344  HSPB2; heat shock protein beta-2 [KO:K09543]
112675367  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
clud04010  MAPK signaling pathway
clud04020  Calcium signaling pathway
clud04066  HIF-1 signaling pathway
clud04150  mTOR signaling pathway
clud04151  PI3K-Akt signaling pathway
clud04210  Apoptosis
clud04310  Wnt signaling pathway
clud04340  Hedgehog signaling pathway
clud04350  TGF-beta signaling pathway
clud04370  VEGF signaling pathway
clud04510  Focal adhesion
clud04520  Adherens junction
clud04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
LinkDB

DBGET integrated database retrieval system