KEGG   PATHWAY: dsp05010
Entry
dsp05010                    Pathway                                
Name
Alzheimer disease - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
dsp05010  Alzheimer disease
dsp05010

Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122114386  Adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
122108773  Adam17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
122105645  amyloid-beta precursor protein isoform X1 [KO:K04520]
122126149  Nae1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
122117629  Apbb1; amyloid-beta A4 precursor protein-binding family B member 1 [KO:K04529]
122110421  Bace1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
122114277  Bace2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
122105029  Rtn3; reticulon-3 [KO:K20723]
122117433  Rtn4; reticulon-4 isoform X1 [KO:K20720]
122097520  Psenen; gamma-secretase subunit PEN-2 [KO:K06170]
122118706  Psen1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
122126773  Psen2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
122109476  Ncstn; nicastrin [KO:K06171]
122114638  Aph1b; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
122109387  Aph1a; gamma-secretase subunit APH-1A isoform X1 [KO:K06172]
122115756  Ide; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
122112611  Mme; neprilysin isoform X1 [KO:K01389] [EC:3.4.24.11]
122103501  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
122102014  NADH-ubiquinone oxidoreductase chain 6 [KO:K03884] [EC:7.1.1.2]
122105042  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
122110984  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
122106236  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
122114211  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
122128220  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
122108040  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
122118108  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
122110711  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
122121867  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
122124167  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
122121866  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
122123541  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
122119662  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
122107085  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
122102116  Ndufa9; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
122115668  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
122116189  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
122122737  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
122119277  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
122100836  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
122118714  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
122105938  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
122096426  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
122126228  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
122098774  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
122099228  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
122120998  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
122119574  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
122115954  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
122102448  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
122123702  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
122111716  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
122107426  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
122109574  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
122104850  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
122117000  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
122107146  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
122120953  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
122122878  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
122105323  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
122127166  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
122116107  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
122120947  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
122099154  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
122109696  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
122124981  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
122110255  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
122097460  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
122098857  cytochrome c1, heme protein, mitochondrial [KO:K00413]
122095608  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
122116160  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
122112477  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
122107694  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
122103356  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122102346  cytochrome b-c1 complex subunit 7 [KO:K00417]
122115447  cytochrome b-c1 complex subunit 8 [KO:K00418]
122097187  cytochrome b-c1 complex subunit 9 [KO:K00419]
122122787  cytochrome b-c1 complex subunit 10 [KO:K00420]
122102258  cytochrome c oxidase subunit 2 [KO:K02261]
122120460  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
122101094  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
122098449  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
122121277  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
122096278  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
122099010  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
122110655  cytochrome c oxidase subunit 6B2 [KO:K02267]
122097523  cytochrome c oxidase subunit 6B1 [KO:K02267]
122112426  cytochrome c oxidase subunit 6C-like [KO:K02268]
122112583  cytochrome c oxidase subunit 6C-like [KO:K02268]
122114643  cytochrome c oxidase subunit 6C-like [KO:K02268]
122102359  cytochrome c oxidase subunit 6C [KO:K02268]
122104575  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
122097524  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
122113939  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
122097646  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
122106921  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
122118596  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
122128078  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122115340  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122117176  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
122118854  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
122104940  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
122104244  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
122102260  ATP synthase subunit alpha, mitochondrial [KO:K02132]
122124046  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
122113006  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
122122875  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
122124616  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
122104432  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
122105773  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
122107641  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
122103388  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
122120084  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
122124362  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
122128375  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
122114301  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
122105474  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
122112017  Hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
122097789  Ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
122115367  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122116516  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122107662  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
122101658  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
122128204  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
122111998  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
122125556  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
122116536  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
122125612  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
122125736  Apoe; apolipoprotein E [KO:K04524]
122124406  Lrp1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
122116005  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122102541  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122099877  Fadd; FAS-associated death domain protein [KO:K02373]
122096450  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122101664  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
122118832  Calm1; calmodulin-1 [KO:K02183]
122104536  Calm2; calmodulin-2 [KO:K02183]
122113235  Calml3; calmodulin-like protein 3 [KO:K02183]
122113280  Calml5; calmodulin-like protein 5 [KO:K02183]
122122996  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122124059  calmodulin-1-like [KO:K02183]
122125740  Calm3; calmodulin-3 [KO:K02183]
122126861  calmodulin-like [KO:K02183]
122127053  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122096621  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122116547  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122110513  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
122122799  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
122105036  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
122110854  cytochrome c-like [KO:K08738]
122112201  cytochrome c, somatic [KO:K08738]
122115021  cytochrome c, testis-specific [KO:K08738]
122124195  cytochrome c, somatic-like [KO:K08738]
122116980  cytochrome c, somatic-like [KO:K08738]
122117286  cytochrome c, somatic-like [KO:K08738]
122119240  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
122099125  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122126104  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122105224  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
122112994  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
122114594  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
122115429  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
122095118  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122120299  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122105124  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122120360  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
122114401  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122102555  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122123837  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
122101235  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122094969  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
122125845  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
122108123  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
122098776  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122126705  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122122998  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
122116572  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122114409  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
122108136  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122100994  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
122111510  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
122096216  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122098533  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
122124839  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
122109183  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
122097163  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
122124058  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
122128373  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122116859  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122099715  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122126135  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122119668  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122097824  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122115378  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122116492  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122117971  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
122123666  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122106531  Psma6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
122100662  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
122120759  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
122123386  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
122104344  Psma8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
122124999  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
122111139  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
122117796  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
122110090  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
122108623  Psmb6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
122107111  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
122103514  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
122111295  Psmb2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
122113388  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
122097243  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
122109362  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
122111905  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
122118644  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
122097397  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
122106459  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
122105126  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
122102009  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
122097063  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
122107359  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
122103275  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
122098523  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
122094924  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
122118095  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
122108147  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
122126198  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
122095018  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
122109213  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
122110797  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
122097575  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
122124990  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
122111954  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
122109968  26S proteasome complex subunit SEM1-like [KO:K10881]
122099033  Nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
122104935  Capn1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
122109365  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
122119897  Cdk5r1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
122099297  Slc39a3; zinc transporter ZIP3 [KO:K14709]
122108044  Slc39a2; zinc transporter ZIP2 isoform X1 [KO:K14709]
122109535  Slc39a1; zinc transporter ZIP1 [KO:K14709]
122098913  Slc39a4; zinc transporter ZIP4 [KO:K14710]
122124141  Slc39a5; zinc transporter ZIP5 [KO:K14711]
122104371  Slc39a6; zinc transporter ZIP6 [KO:K14712]
122111095  Slc39a7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
122127194  Slc39a8; metal cation symporter ZIP8 [KO:K14714]
122118618  Slc39a9; zinc transporter ZIP9 [KO:K14715]
122114990  Slc39a10; zinc transporter ZIP10 [KO:K14716]
122102239  Slc39a11; zinc transporter ZIP11 isoform X1 [KO:K14717]
122113293  Slc39a12; zinc transporter ZIP12 isoform X1 [KO:K14718]
122105290  Slc39a13; zinc transporter ZIP13 isoform X1 [KO:K14719]
122096627  Slc39a14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
122098342  Slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
122105882  Cdk5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
122096813  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
122115995  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122127254  Dkk2; dickkopf-related protein 2 [KO:K02165]
122107683  Dkk4; dickkopf-related protein 4 [KO:K02165]
122115924  Dkk1; dickkopf-related protein 1 [KO:K02165]
122106358  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
122104095  Wnt2b; protein Wnt-2b [KO:K00182]
122121825  Wnt2; protein Wnt-2 [KO:K00182]
122103469  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
122098964  Wnt3a; protein Wnt-3a [KO:K00312]
122115226  Wnt4; protein Wnt-4 [KO:K00408]
122099575  Wnt5b; LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
122108141  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
122107573  Wnt6; protein Wnt-6 [KO:K00445]
122096831  Wnt7b; protein Wnt-7b [KO:K00572]
122108198  Wnt7a; protein Wnt-7a [KO:K00572]
122115988  Wnt8b; protein Wnt-8b [KO:K00714]
122118246  Wnt8a; protein Wnt-8a [KO:K00714]
122103516  Wnt9b; protein Wnt-9b [KO:K01064]
122098938  Wnt9a; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
122106350  Wnt10b; protein Wnt-10b [KO:K01357]
122107497  Wnt10a; protein Wnt-10a [KO:K01357]
122115365  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
122121786  Wnt16; protein Wnt-16 [KO:K01558]
122096462  Fzd7; frizzled-7 [KO:K02432]
122111920  Fzd1; frizzled-1 [KO:K02432]
122103290  Fzd2; frizzled-2 [KO:K02235]
122125249  Fzd3; frizzled-3 isoform X1 [KO:K02329]
122114819  Fzd4; frizzled-4 [KO:K02354]
122113306  Fzd8; frizzled-8 [KO:K02375]
122107578  Fzd5; frizzled-5 [KO:K02375]
122102404  Fzd6; frizzled-6 [KO:K02376]
122113827  Fzd9; frizzled-9 [KO:K02842]
122098849  Fzd10; frizzled-10 [KO:K02842]
122104921  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
122101230  Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
122119159  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
122127322  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
122096769  Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
122100418  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
122115816  Frat1; proto-oncogene FRAT1 [KO:K03069]
122115797  Frat2; GSK-3-binding protein FRAT2 [KO:K03096]
122120178  Csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
122102234  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
122111124  Csnk2b; casein kinase II subunit beta [KO:K03115]
122098148  Axin1; axin-1 isoform X1 [KO:K02157]
122094958  Axin2; axin-2 [KO:K04385]
122122822  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
122118219  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122124883  Ctnnb1; catenin beta-1 [KO:K02105]
122121043  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
122113719  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122113956  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122118200  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
122110785  Kif5c; kinesin heavy chain [KO:K10396]
122113307  Kif5b; kinesin-1 heavy chain [KO:K10396]
122124175  Kif5a; kinesin heavy chain [KO:K10396]
122105369  Klc2; kinesin light chain 2 isoform X1 [KO:K10407]
122122623  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
122101486  Klc4; kinesin light chain 4 [KO:K10407]
122125693  Klc3; kinesin light chain 3 [KO:K10407]
122095975  tubulin alpha-3 chain [KO:K07374]
122095976  tubulin alpha-3 chain-like [KO:K07374]
122113137  tubulin alpha chain-like 3 [KO:K07374]
122106151  Tuba1b; tubulin alpha-1B chain [KO:K07374]
122106173  tubulin alpha-1A chain [KO:K07374]
122106264  Tuba1c; tubulin alpha-1C chain [KO:K07374]
122107361  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
122107474  Tuba4a; tubulin alpha-4A chain [KO:K07374]
122101672  Tuba8; LOW QUALITY PROTEIN: tubulin alpha-8 chain [KO:K07374]
122127587  tubulin beta chain-like isoform X1 [KO:K07375]
122095233  tubulin beta chain-like [KO:K07375]
122110948  Tubb6; tubulin beta-6 chain [KO:K07375]
122127945  Tubb3; tubulin beta-3 chain [KO:K07375]
122128004  tubulin beta chain-like isoform X1 [KO:K07375]
122128109  tubulin beta chain-like isoform X1 [KO:K07375]
122111310  Tubb; tubulin beta chain [KO:K07375]
122096962  tubulin beta chain-like isoform X1 [KO:K07375]
122097259  tubulin beta chain-like [KO:K07375]
122121084  tubulin beta chain-like [KO:K07375]
122121153  tubulin beta chain-like [KO:K07375]
122121914  tubulin beta chain-like [KO:K07375]
122122727  Tubb4a; tubulin beta-4A chain [KO:K07375]
122099599  tubulin beta chain-like isoform X1 [KO:K07375]
122107163  tubulin beta chain-like isoform X1 [KO:K07375]
122100153  tubulin beta chain-like isoform X1 [KO:K07375]
122100529  tubulin beta chain-like isoform X1 [KO:K07375]
122108390  Tubb2a; tubulin beta-2A chain [KO:K07375]
122108391  tubulin beta-2B chain [KO:K07375]
122124602  Tubb1; tubulin beta-1 chain [KO:K07375]
122101130  tubulin beta chain-like isoform X1 [KO:K07375]
122108734  tubulin beta chain-like isoform X1 [KO:K07375]
122116339  tubulin beta chain-like isoform X1 [KO:K07375]
122116342  tubulin beta chain-like isoform X1 [KO:K07375]
122124845  tubulin beta chain-like isoform X1 [KO:K07375]
122124905  tubulin beta chain-like [KO:K07375]
122125926  tubulin beta chain-like isoform X1 [KO:K07375]
122102548  Tubb4b; tubulin beta-4B chain [KO:K07375]
122102987  tubulin beta chain-like [KO:K07375]
122103043  tubulin beta chain-like isoform X1 [KO:K07375]
122103060  tubulin beta chain-like isoform X1 [KO:K07375]
122103096  tubulin beta chain-like isoform X1 [KO:K07375]
122126428  tubulin beta chain-like [KO:K07375]
122126974  tubulin beta chain-like isoform X1 [KO:K07375]
122111560  Ager; advanced glycosylation end product-specific receptor [KO:K19722]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122118367  Nras; GTPase NRas [KO:K07828]
122098764  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122105936  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122099331  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122110441  Nox1; NADPH oxidase 1 isoform X1 [KO:K08008]
122128141  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
122114828  Nox4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
122105094  Rela; transcription factor p65 isoform X1 [KO:K04735]
122127164  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122120264  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
122103768  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122111281  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
122112101  interleukin-6-like [KO:K05405]
122112102  interleukin-6-like [KO:K05405]
122112217  interleukin-6-like [KO:K05405]
122100603  Il1a; interleukin-1 alpha [KO:K04383]
122100606  Il1b; interleukin-1 beta [KO:K04519]
122109178  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122127156  Snca; alpha-synuclein [KO:K04528]
122104582  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
122115917  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122107663  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122097005  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122102073  Ins; insulin [KO:K04526]
122119565  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122107464  Irs1; insulin receptor substrate 1 [KO:K16172]
122122851  Irs2; insulin receptor substrate 2 [KO:K07187]
122113664  insulin receptor substrate 1-like [KO:K17445]
122116357  Irs4; insulin receptor substrate 4 [KO:K17446]
122108047  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122100872  Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122117343  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122095294  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122121501  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122107232  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122123339  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122121508  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122102030  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
122101941  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
122098366  Atg101; autophagy-related protein 101 [KO:K19730]
122105296  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
122121924  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
122104920  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
122103677  Becn2; beclin-2 [KO:K08334]
122101465  Becn1; beclin-1 [KO:K08334]
122095662  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
122110021  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
122122128  nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
122122358  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
122104335  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
122118652  Atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
122104662  Atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
122094925  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
122113746  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
dsp00190  Oxidative phosphorylation
dsp03050  Proteasome
dsp04020  Calcium signaling pathway
dsp04140  Autophagy - animal
dsp04141  Protein processing in endoplasmic reticulum
dsp04210  Apoptosis
dsp04310  Wnt signaling pathway
dsp04910  Insulin signaling pathway
dsp04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system