Entry
Name
Fc epsilon RI signaling pathway - Equus caballus (horse)
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
ecb04664 Fc epsilon RI signaling pathway
Ortholog table
Other DBs
Organism
Equus caballus (horse) [GN:
ecb ]
Gene
100057308 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha precursor [KO:K08089 ]
100033954 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta isoform X1 [KO:K08090 ]
100034137 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983 ]
106782043 high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
100070545 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116 ] [EC:3.1.4.11 ]
100055670 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859 ] [EC:3.1.4.11 ]
100051623 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100058141 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100051753 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100052122 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100050227 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
100146348 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100061732 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100054701 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860 ]
100054738 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100033981 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
100057737 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
100069175 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
100064430 LAT; linker for activation of T-cells family member 1 [KO:K07362 ]
100034178 ALOX5AP; arachidonate 5-lipoxygenase-activating protein [KO:K20735 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Kawakami T, Galli SJ.
Title
Regulation of mast-cell and basophil function and survival by IgE.
Journal
Reference
Authors
Siraganian RP.
Title
Mast cell signal transduction from the high-affinity IgE receptor.
Journal
Reference
Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title
Immunobiology 6th edition
Journal
Garland Science Publishing (2005)
Reference
Authors
Turner H, Kinet JP.
Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal
Reference
Authors
Gilfillan AM, Tkaczyk C.
Title
Integrated signalling pathways for mast-cell activation.
Journal
Reference
Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal
Reference
Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title
Essential role for Gab2 in the allergic response.
Journal
Reference
Authors
Nadler MJ, Kinet JP.
Title
Uncovering new complexities in mast cell signaling.
Journal
Related pathway
ecb04070 Phosphatidylinositol signaling system
KO pathway
LinkDB
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