KEGG   PATHWAY: esp04510
Entry
esp04510                    Pathway                                
Name
Focal adhesion - Etheostoma spectabile (orangethroat darter)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
esp04510  Focal adhesion
esp04510

Other DBs
GO: 0005925
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116701464  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
116671215  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
116703513  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
116692048  collagen alpha-1(II) chain-like isoform X1 [KO:K19719]
116688445  collagen alpha-1(II) chain isoform X1 [KO:K19719]
116697722  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
116698394  col4a1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
116699273  LOW QUALITY PROTEIN: collagen alpha-4(IV) chain-like [KO:K06237]
116699283  LOW QUALITY PROTEIN: collagen alpha-5(IV) chain-like [KO:K06237]
116684671  LOW QUALITY PROTEIN: collagen alpha-5(IV) chain-like [KO:K06237]
116707338  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116669489  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
116697674  collagen alpha-2(VI) chain-like [KO:K06238]
116698428  col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
116698699  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
116698700  col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
116679334  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain-like [KO:K06238]
116704895  col9a1; collagen alpha-1(IX) chain [KO:K08131]
116692515  col9a3; collagen alpha-3(IX) chain [KO:K08131]
116701245  collagen alpha-3(IX) chain-like isoform X1 [KO:K08131]
116701498  col9a2; collagen alpha-2(IX) chain [KO:K08131]
116706683  lama2; laminin subunit alpha-2 [KO:K05637]
116698492  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
116669984  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
116705940  lama4; laminin subunit alpha-4 [KO:K06241]
116673333  laminin subunit beta-1-like [KO:K05636]
116677570  LOW QUALITY PROTEIN: laminin subunit beta-1-like [KO:K05636]
116691873  lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
116692975  laminin subunit beta-2-like [KO:K06243]
116688517  lamb3; laminin subunit beta-3 isoform X1 [KO:K06244]
116677569  laminin subunit beta-4-like isoform X1 [KO:K06245]
116697085  lamc2; LOW QUALITY PROTEIN: laminin subunit gamma-2 [KO:K06246]
116704341  lamc3; laminin subunit gamma-3 [KO:K06247]
116670903  chad; chondroadherin [KO:K06248]
116694204  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116706057  thrombospondin-1-like [KO:K16857]
116670144  thbs1; thrombospondin-1 [KO:K16857]
116704791  thrombospondin-4-B-like [KO:K04659]
116704891  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
116671146  thrombospondin-2-like [KO:K04659]
116696012  thrombospondin-4-like [KO:K04659]
116689235  thrombospondin-4-B-like [KO:K04659]
116698421  LOW QUALITY PROTEIN: fibronectin-like [KO:K05717]
116706203  fn1; fibronectin isoform X1 [KO:K05717]
116700186  vitronectin-like [KO:K06251]
116687137  vtn; vitronectin [KO:K06251]
116704267  tenascin-like isoform X1 [KO:K06252]
116704587  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
116691005  tenascin-like [KO:K06252]
116698623  tnr; tenascin-R isoform X1 [KO:K06252]
116699372  tnn; tenascin-N [KO:K06252]
116689277  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
116694167  vwf; von Willebrand factor [KO:K03900]
116704787  itga1; integrin alpha-1 [KO:K06480]
116689477  itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
116671152  itga3; integrin alpha-3 [KO:K06482]
116697981  itga4; integrin alpha-4 [KO:K06483]
116693125  LOW QUALITY PROTEIN: integrin alpha-5-like [KO:K06484]
116687553  itga5; integrin alpha-5 [KO:K06484]
116698403  itga6; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
116698830  integrin alpha-6-like isoform X1 [KO:K06485]
116687421  itga7; integrin alpha-7 isoform X1 [KO:K06583]
116691646  itga8; integrin alpha-8 [KO:K06584]
116705775  itga9; integrin alpha-9 [KO:K06585]
116690803  itga10; integrin alpha-10 [KO:K06586]
116690676  itga11; integrin alpha-11 isoform X1 [KO:K06587]
116672030  itgb1; integrin beta-1 isoform X1 [KO:K05719]
116698833  integrin beta-1-like isoform X1 [KO:K05719]
116670728  integrin beta-3-like [KO:K06493]
116702297  integrin beta-3-like [KO:K06493]
116671118  itgb4; integrin beta-4 isoform X1 [KO:K06525]
116689863  itgb5; integrin beta-5 [KO:K06588]
116669838  itgb6; integrin beta-6 [KO:K06589]
116701571  itgb8; integrin beta-8 [KO:K06591]
116703074  emp2; epithelial membrane protein 2 [KO:K26256]
116700400  platelet-derived growth factor subunit A-like [KO:K04359]
116703151  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116700940  myb-like protein Q isoform X1 [KO:K17386]
116683329  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116696522  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
116696510  egf; pro-epidermal growth factor [KO:K04357]
116673369  igf1; insulin-like growth factor I [KO:K05459]
116691938  insulin-like growth factor I [KO:K05459]
116697380  vegfb; vascular endothelial growth factor B [KO:K05448]
116706224  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
116699327  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
116706644  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
116670486  placenta growth factor-like isoform X1 [KO:K16859]
116673735  vascular endothelial growth factor C-like [KO:K05449]
116702284  vegfc; vascular endothelial growth factor C [KO:K05449]
116672012  vegfd; vascular endothelial growth factor D [KO:K05449]
116694689  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116673226  hepatocyte growth factor-like isoform X1 [KO:K05460]
116695589  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116696884  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116694009  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
116694654  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116695590  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116698815  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116697253  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
116672533  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
116697226  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116693711  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116671269  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116703557  emp1; epithelial membrane protein 1 [KO:K26255]
116704770  epithelial membrane protein 2-like [KO:K26255]
116692732  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
116687594  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
116678507  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
116700588  LOW QUALITY PROTEIN: rho GTPase-activating protein 35-like [KO:K05732]
116686302  arhgap5; LOW QUALITY PROTEIN: rho GTPase-activating protein 5 [KO:K13709]
116691940  rho-related GTP-binding protein RhoA-C [KO:K04513]
116692018  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
116692455  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
116687703  rho-related GTP-binding protein RhoA-B [KO:K04513]
116688259  rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
116698610  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
116705871  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
116670634  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116686662  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
116687400  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116689310  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
116689632  myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
116688064  myosin regulatory light polypeptide 9 [KO:K12755]
116698538  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
116672459  myosin regulatory light polypeptide 9 [KO:K12757]
116671334  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
116703217  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
116679804  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116706431  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116707200  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116669662  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116686659  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116671320  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
116702550  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
116689305  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
116673322  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116704390  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
116694165  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K17457]
116671707  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
116699211  LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
116695568  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116702937  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
116691384  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116699144  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116701654  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116696108  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116689248  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
116703860  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116701733  actin, cytoplasmic 2 [KO:K05692]
116703193  actb; actin, cytoplasmic 1 [KO:K05692]
116690550  ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349]
116694238  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
116704839  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
116675778  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
116670542  alpha-actinin-1 [KO:K05699]
116704583  talin-1 isoform X1 [KO:K06271]
116691856  talin-2 [KO:K06271]
116693910  tln2; talin-2 isoform X1 [KO:K06271]
116693200  filamin-A-like isoform X1 [KO:K04437]
116690346  flocculation protein FLO11-like isoform X1 [KO:K05760]
116701018  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
116671424  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
116691232  zyx; zyxin [KO:K06273]
116673147  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
116679987  vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116705377  vinculin-like isoform X1 [KO:K05700]
116671183  vinculin isoform X1 [KO:K05700]
116686712  alpha-parvin [KO:K06275]
116694635  parvb; beta-parvin isoform X1 [KO:K06275]
116694636  parvg; gamma-parvin isoform X1 [KO:K06275]
116671370  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
116673342  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116705099  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116670120  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116673142  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
116698290  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116691343  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
116701310  catenin beta-1-like [KO:K02105]
116670566  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116702478  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116705456  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116703070  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116691362  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
116691433  LOW QUALITY PROTEIN: focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
116701641  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
116675754  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116678381  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116699195  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116692529  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116695417  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116698567  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116699207  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
116695430  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116696146  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116689915  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
116704085  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116705301  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116698498  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3-like [KO:K05730]
116707274  vav1; proto-oncogene vav isoform X1 [KO:K05730]
116672078  vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116704092  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116670942  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116702491  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116704504  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116671546  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116704619  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116685041  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116670013  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
116695614  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116700229  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
116686972  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
116706251  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
116670002  pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
116691327  cell division control protein 42 homolog [KO:K04393]
116692170  cell division control protein 42 homolog isoform X1 [KO:K04393]
116701833  cell division control protein 42 homolog [KO:K04393]
116688288  cell division control protein 42 homolog isoform X1 [KO:K04393]
116694598  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
116674771  crk; adapter molecule crk [KO:K04438]
116700737  adapter molecule crk-like [KO:K04438]
116703898  crkl; crk-like protein [KO:K04438]
116670996  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116704339  rapgef1; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1 [KO:K06277]
116692093  ras-related protein Rap-1b [KO:K04353]
116688344  ras-related protein Rap-1A-like [KO:K04353]
116697416  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
116705432  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
116671539  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116703876  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116677748  transcription factor AP-1-like [KO:K04448]
116698745  transcription factor AP-1-like [KO:K04448]
116695201  transcription factor AP-1-like [KO:K04448]
116704060  transcription factor AP-1-like [KO:K04448]
116673193  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116693796  cav1; caveolin-1 [KO:K06278]
116691899  caveolin-2-like [KO:K12958]
116693808  cav2; caveolin-2 [KO:K12958]
116688249  caveolin-2-like [KO:K12958]
116688419  caveolin-2-like [KO:K12958]
116688422  cav3; LOW QUALITY PROTEIN: caveolin-3 [KO:K12959]
116705947  fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
116679832  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
116669655  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
116691703  shc1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
116696202  LOW QUALITY PROTEIN: SHC-transforming protein 2-like [KO:K17447]
116704435  shc3; SHC-transforming protein 3 [KO:K17448]
116703619  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
116702397  grb2; growth factor receptor-bound protein 2 [KO:K04364]
116678819  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
116669702  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116694245  hras; GTPase HRas [KO:K02833]
116693071  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116694773  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116690322  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116703753  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
116679543  ETS domain-containing protein Elk-1-like [KO:K04375]
116694578  G1/S-specific cyclin-D1-like [KO:K04503]
116703178  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
116673298  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
116703090  G1/S-specific cyclin-D2-like [KO:K10151]
116687691  G1/S-specific cyclin-D2-like [KO:K10152]
116700009  inhibitor of apoptosis protein-like [KO:K16060]
116697435  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116707131  bad; bcl2-associated agonist of cell death [KO:K02158]
116698657  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
esp04010  MAPK signaling pathway
esp04060  Cytokine-cytokine receptor interaction
esp04070  Phosphatidylinositol signaling system
esp04110  Cell cycle
esp04310  Wnt signaling pathway
esp04512  ECM-receptor interaction
esp04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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