KEGG   PATHWAY: gja04810
Entry
gja04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Gekko japonicus (Schlegel's Japanese gecko)
Class
Cellular Processes; Cell motility
Pathway map
gja04810  Regulation of actin cytoskeleton
gja04810

Other DBs
GO: 0030036
Organism
Gekko japonicus (Schlegel's Japanese gecko) [GN:gja]
Gene
107114523  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107108929  lysophosphatidic acid receptor 2-like [KO:K04289]
107124321  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
107125005  lysophosphatidic acid receptor 6-like [KO:K04275]
107121365  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
107118407  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
107115414  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
107106779  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
107123146  proteinase-activated receptor 1-like [KO:K03914]
107123148  proteinase-activated receptor 1-like [KO:K03914]
107123150  proteinase-activated receptor 1-like [KO:K03914]
107123376  INS; insulin-like [KO:K04526]
107122699  EGF; epidermal growth factor [KO:K04357]
107113068  FGF1; fibroblast growth factor 1 [KO:K18496]
107109560  FGF2; fibroblast growth factor 2 [KO:K18497]
107112547  FGF18; fibroblast growth factor 18 [KO:K04358]
107107945  FGF5; fibroblast growth factor 5 [KO:K04358]
107126231  FGF22; fibroblast growth factor 22 [KO:K04358]
107123230  FGF16; fibroblast growth factor 16 [KO:K04358]
107115357  FGF9; fibroblast growth factor 9 [KO:K04358]
107124462  FGF7; fibroblast growth factor 7 [KO:K04358]
107110406  FGF6; fibroblast growth factor 6 [KO:K04358]
107114445  FGF8; fibroblast growth factor 8 [KO:K04358]
107120325  FGF17; fibroblast growth factor 17 [KO:K04358]
107116759  FGF20; fibroblast growth factor 20 [KO:K04358]
107121500  FGF3; fibroblast growth factor 3 [KO:K04358]
107121520  FGF4; fibroblast growth factor 4 [KO:K04358]
107121547  FGF10; fibroblast growth factor 10 [KO:K04358]
107121501  FGF19; fibroblast growth factor 19 [KO:K22603]
107106394  fibroblast growth factor 21-like [KO:K22429]
107110402  FGF23; fibroblast growth factor 23 [KO:K22428]
107115509  PDGFA; platelet derived growth factor subunit A [KO:K04359]
107117132  PDGFB; platelet derived growth factor subunit B [KO:K17386]
107126145  PDGFD; platelet derived growth factor D [KO:K05450]
107126248  PDGFC; platelet derived growth factor C [KO:K05450]
107114887  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
107119225  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
107113006  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
107112647  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
107111538  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107106036  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107121182  FN1; fibronectin 1 [KO:K05717]
107116961  ITGA1; integrin subunit alpha 1 [KO:K06480]
107116970  ITGA2; integrin subunit alpha 2 [KO:K06481]
107112527  ITGA3; integrin subunit alpha 3 [KO:K06482]
107106004  ITGA4; integrin subunit alpha 4 [KO:K06483]
107119049  ITGA5; integrin subunit alpha 5 [KO:K06484]
107107039  ITGA6; integrin subunit alpha 6 [KO:K06485]
107105864  ITGA7; integrin subunit alpha 7 [KO:K06583]
107120962  ITGA8; integrin subunit alpha 8 [KO:K06584]
107105731  ITGA9; integrin subunit alpha 9 [KO:K06585]
107110085  ITGA10; integrin subunit alpha 10 [KO:K06586]
107113280  ITGA11; integrin subunit alpha 11 [KO:K06587]
107121779  ITGAV; integrin subunit alpha V [KO:K06487]
107111209  ITGAL; integrin subunit alpha L [KO:K05718]
107106207  integrin alpha-M-like [KO:K06461]
107106692  ITGAE; integrin subunit alpha E [KO:K06524]
107125566  ITGB1; integrin subunit beta 1 [KO:K05719]
107117606  ITGB2; integrin subunit beta 2 [KO:K06464]
107109989  integrin beta-3-like [KO:K06493]
107112937  integrin beta-3-like [KO:K06493]
107113186  ITGB4; integrin subunit beta 4 [KO:K06525]
107106324  ITGB5; integrin subunit beta 5 [KO:K06588]
107126129  ITGB6; integrin subunit beta 6 [KO:K06589]
107118966  ITGB7; integrin subunit beta 7 [KO:K06590]
107123057  ITGB8; integrin subunit beta 8 [KO:K06591]
107112650  BDKRB2; bradykinin receptor B2 [KO:K03916]
107111024  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
107119224  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
107119040  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
107107913  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
107116075  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
107124805  C5; complement C5 [KO:K03994]
107108807  complement component C6-like [KO:K03995]
107108813  complement component C6-like [KO:K03995]
107108808  C7; complement C7 [KO:K03996]
107118036  C8A; complement C8 alpha chain [KO:K03997]
107118034  C8B; complement C8 beta chain [KO:K03998]
107117958  C9; complement C9 [KO:K04000]
107116703  GNA12; G protein subunit alpha 12 [KO:K04346]
107105951  GNA13; G protein subunit alpha 13 [KO:K04639]
107114357  GNG12; G protein subunit gamma 12 [KO:K04347]
107114377  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
107118814  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
107107898  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
107108519  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
107117460  crk-like protein [KO:K04438]
107119408  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
107106401  dedicator of cytokinesis protein 1-like [KO:K13708]
107106402  dedicator of cytokinesis protein 1 [KO:K13708]
107109696  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
107122628  son of sevenless homolog 2-like [KO:K03099]
107116186  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
107112057  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
107106941  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
107116614  GTPase HRas-like [KO:K07827]
107108106  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07830]
107113523  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
107122828  MRAS; muscle RAS oncogene homolog [KO:K07831]
107121175  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
107110982  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
107110507  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
107107376  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
107118085  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107108905  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
107119473  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
107121678  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
107109021  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
107106561  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
107112000  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
107119936  guanine nucleotide exchange factor VAV3-like [KO:K05730]
107109049  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
107120717  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
107119310  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
107108795  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
107118023  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
107113874  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
107121194  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107118240  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107117455  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107115252  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107108180  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
107107366  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
107121519  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107108545  RGCC; regulator of cell cycle [KO:K26108]
107123495  rho guanine nucleotide exchange factor 1-like [KO:K12330]
107108209  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
107121227  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
107124777  transforming protein RhoA-like [KO:K04513]
107106083  transforming protein RhoA-like [KO:K04513]
107107158  RHOA; ras homolog family member A [KO:K04513]
107123053  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
107120055  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
107118111  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
107116700  CDC42; cell division cycle 42 [KO:K04393]
107118386  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
107113978  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
107106346  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
107116363  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
107123895  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
107119643  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
107118933  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
107119545  GIT1; GIT ArfGAP 1 [KO:K05737]
107120578  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107114818  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
107113908  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
107108885  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
107106205  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
107124492  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
107112146  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
107113829  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
107125719  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
107112184  MYL2; myosin light chain 2 [KO:K10351]
107117236  MYL5; myosin light chain 5 [KO:K12753]
107117400  MYL7; myosin light chain 7 [KO:K12754]
107112280  MYL9; myosin light chain 9 [KO:K12755]
107107690  MYL10; myosin light chain 10 [KO:K12756]
107118014  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
107106266  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
107109334  MYH11; myosin heavy chain 11 [KO:K10352]
107109545  MYH9; myosin heavy chain 9 [KO:K10352]
107111148  myosin-10-like [KO:K10352]
107123850  MYH10; myosin heavy chain 10 [KO:K10352]
107110352  DIAPH1; diaphanous related formin 1 [KO:K05740]
107111172  DIAPH2; diaphanous related formin 2 [KO:K05741]
107110810  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
107105814  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
107118282  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
107121582  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
107106766  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
107120792  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
107119202  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
107105889  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
107112406  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
107126094  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
107122538  DIAPH3; diaphanous related formin 3 [KO:K05745]
107108222  BAIAP2; BAI1 associated protein 2 [KO:K05627]
107113130  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
107117862  protein enabled homolog [KO:K05746]
107120737  wiskott-Aldrich syndrome protein homolog [KO:K23612]
107115724  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107112840  wiskott-Aldrich syndrome protein-like [KO:K23612]
107116649  WASF2; WAS protein family member 2 [KO:K05748]
107124835  cytoplasmic FMR1-interacting protein 2 [KO:K05749]
107110223  cytoplasmic FMR1-interacting protein 1 [KO:K05749]
107106014  nck-associated protein 1 [KO:K05750]
107119051  NCKAP1L; NCK associated protein 1 like [KO:K05750]
107107252  ABI2; abl interactor 2 [KO:K05751]
107107145  BRK1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
107106878  WASF1; WAS protein family member 1 [KO:K05753]
107107618  actin-related protein 2 [KO:K17260]
107115229  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
107105613  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
107123154  actin-related protein 3B [KO:K18584]
107116920  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
107116923  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
107109411  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
107115903  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
107119103  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
107117513  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
107119961  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
107106287  actin, cytoplasmic 1-like [KO:K05692]
107108307  ACTG1; actin gamma 1 [KO:K05692]
107117852  actin, cytoplasmic type 5 [KO:K05692]
107121971  PFN2; profilin 2 [KO:K05759]
107107722  PFN4; profilin family member 4 [KO:K05759]
107114138  profilin-1-like [KO:K05759]
107122301  PFN3; profilin 3 [KO:K05759]
107124432  PFN1; profilin 1 [KO:K05759]
107122298  PXN; paxillin [KO:K05760]
107106614  EZR; ezrin [KO:K08007]
107126002  RDX; radixin [KO:K05762]
107119169  MSN; moesin [KO:K05763]
107124268  TMSB4X; thymosin beta 4, X-linked [KO:K05764]
107125501  thymosin beta-4-like [KO:K05764]
107114813  CFL2; cofilin 2 [KO:K05765]
107121075  CFL1; cofilin 1 [KO:K05765]
107119560  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107112139  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107116820  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107113229  VCL; vinculin [KO:K05700]
107109718  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
107123149  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
107118046  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
107114413  GSN; gelsolin [KO:K05768]
107117478  SCIN; scinderin [KO:K05768]
107106834  ACTN4; actinin alpha 4 [KO:K05699]
107112209  ACTN1; actinin alpha 1 [KO:K05699]
107116684  APC; APC, WNT signaling pathway regulator [KO:K02085]
107116347  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
107124056  rho guanine nucleotide exchange factor 4-like [KO:K05769]
107117276  SPATA13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
gja04010  MAPK signaling pathway
gja04510  Focal adhesion
gja04520  Adherens junction
KO pathway
ko04810   
LinkDB

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