KEGG   PATHWAY: hai04510
Entry
hai04510                    Pathway                                
Name
Focal adhesion - Hipposideros armiger (great roundleaf bat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
hai04510  Focal adhesion
hai04510

Other DBs
GO: 0005925
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109380648  COL1A1; collagen alpha-1(I) chain [KO:K06236]
109371948  COL1A2; collagen alpha-2(I) chain [KO:K06236]
109372512  COL2A1; collagen alpha-1(II) chain [KO:K19719]
109396325  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109393347  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
109393353  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109390501  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109383936  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109383910  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109374954  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
109374373  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
109373828  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109373829  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
109395820  collagen alpha-4(VI) chain-like [KO:K06238]
109380077  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
109383345  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
109394154  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
109375466  laminin subunit alpha-2 [KO:K05637]
109377451  LAMA1; laminin subunit alpha-1 [KO:K05637]
109380081  LAMA5; laminin subunit alpha-5 [KO:K06240]
109390109  LAMA3; laminin subunit alpha-3 [KO:K06240]
109384762  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
109372668  LAMB1; laminin subunit beta-1 [KO:K05636]
109376158  laminin subunit beta-2-like isoform X1 [KO:K06243]
109376176  laminin subunit beta-2 isoform X1 [KO:K06243]
109396115  LAMB3; laminin subunit beta-3 [KO:K06244]
109372664  LAMB4; laminin subunit beta-4 [KO:K06245]
109379100  laminin subunit gamma-1 [KO:K05635]
109379101  LAMC2; laminin subunit gamma-2 [KO:K06246]
109380683  LAMC3; laminin subunit gamma-3 [KO:K06247]
109380758  CHAD; chondroadherin [KO:K06248]
109389504  RELN; reelin [KO:K06249] [EC:3.4.21.-]
109384080  THBS1; thrombospondin-1 [KO:K16857]
109381904  THBS4; thrombospondin-4 [KO:K04659]
109382454  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
109393407  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
109391677  THBS2; thrombospondin-2 [KO:K04659]
109380590  FN1; fibronectin isoform X1 [KO:K05717]
109396331  SPP1; osteopontin [KO:K06250]
109385176  VTN; vitronectin [KO:K06251]
109385116  TNN; tenascin-N [KO:K06252]
109385122  TNR; tenascin-R [KO:K06252]
109373091  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
109390423  TNC; tenascin isoform X1 [KO:K06252]
109373317  VWF; von Willebrand factor [KO:K03900]
109396344  IBSP; bone sialoprotein 2 [KO:K06253]
109382143  ITGA1; integrin alpha-1 [KO:K06480]
109382125  ITGA2; integrin alpha-2 [KO:K06481]
109394948  ITGA2B; integrin alpha-IIb [KO:K06476]
109380829  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
109392600  ITGA4; integrin alpha-4 [KO:K06483]
109391860  ITGA5; integrin alpha-5 [KO:K06484]
109390397  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109396843  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
109374603  ITGA8; integrin alpha-8 [KO:K06584]
109385214  ITGA9; integrin alpha-9 [KO:K06585]
109373692  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109385221  ITGA11; integrin alpha-11 [KO:K06587]
109372713  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
109388160  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109380323  ITGB3; integrin beta-3 [KO:K06493]
109383761  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109387967  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109379873  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109391828  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109386990  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109387180  EMP2; epithelial membrane protein 2 [KO:K26256]
109380137  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109392273  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109372936  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109394938  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109379436  EGF; pro-epidermal growth factor [KO:K04357]
109387785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109382864  VEGFA; vascular endothelial growth factor A [KO:K05448]
109384216  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
109381519  PGF; placenta growth factor isoform X1 [KO:K16859]
109395927  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109387670  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
109392334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109381815  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
109375002  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109380372  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109381812  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109388365  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109395227  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109390085  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
109392740  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109389346  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109380800  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109383116  EMP1; epithelial membrane protein 1 [KO:K26255]
109377191  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109372218  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
109390371  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
109376114  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
109393560  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
109388840  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109386644  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
109386121  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
109386122  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
109390950  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
109373005  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
109389577  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109385005  MYL10; myosin regulatory light chain 10 [KO:K12756]
109394738  myosin regulatory light chain 12B [KO:K12757]
109394739  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
109374175  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109385685  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109384139  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109386108  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109375211  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109380462  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
109373751  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
109383050  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109384471  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109388085  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109388601  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109372273  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
109392539  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
109393048  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109380220  ACTB; actin, cytoplasmic 1 [KO:K05692]
109381402  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
109381194  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
109382080  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
109395369  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
109387083  TLN2; talin-2 [KO:K06271]
109393752  TLN1; talin-1 isoform X1 [KO:K06271]
109377338  FLNA; filamin-A isoform X1 [KO:K04437]
109388247  FLNB; filamin-B isoform X1 [KO:K27392]
109386147  paxillin-like [KO:K05760]
109386148  mediator of DNA damage checkpoint protein 1-like [KO:K05760]
109376531  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
109376374  ZYX; zyxin [KO:K06273]
109374736  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
109372637  VCL; vinculin isoform X1 [KO:K05700]
109388282  PARVA; LOW QUALITY PROTEIN: alpha-parvin [KO:K06275]
109387612  PARVG; gamma-parvin [KO:K06275]
109376428  PARVB; beta-parvin [KO:K06275]
109385875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109388396  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109377341  CTNNB1; catenin beta-1 [KO:K02105]
109380289  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109386578  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109372505  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109390857  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109387530  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109381168  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109374297  guanine nucleotide exchange factor VAV3 [KO:K05730]
109378054  VAV1; proto-oncogene vav [KO:K05730]
109375381  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109394502  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109393041  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109376015  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109387639  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109392102  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
109395380  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
109378999  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
109384074  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
109396744  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109384807  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
109386906  CRK; adapter molecule crk isoform X1 [KO:K04438]
109376239  CRKL; crk-like protein [KO:K04438]
109389001  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109380820  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
109373546  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109381707  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
109392215  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109377948  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109392748  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109371251  JUN; transcription factor AP-1 [KO:K04448]
109371257  transcription factor AP-1 [KO:K04448]
109395605  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109389343  CAV1; caveolin-1 isoform X1 [KO:K06278]
109389345  CAV2; caveolin-2 isoform X1 [KO:K12958]
109387266  CAV3; caveolin-3 [KO:K12959]
109384758  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
109393422  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
109390676  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
109376923  SHC3; SHC-transforming protein 3 [KO:K17448]
109394486  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
109383688  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109385471  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109375221  SOS2; son of sevenless homolog 2 [KO:K03099]
109375639  HRAS; GTPase HRas isoform X1 [KO:K02833]
109385150  GTPase HRas-like [KO:K02833]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109376565  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
109389297  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
109392488  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109382891  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109375115  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
109375125  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
109376360  LOW QUALITY PROTEIN: putative inhibitor of apoptosis [KO:K16060]
109390892  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109390784  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
hai04010  MAPK signaling pathway
hai04060  Cytokine-cytokine receptor interaction
hai04070  Phosphatidylinositol signaling system
hai04110  Cell cycle
hai04151  PI3K-Akt signaling pathway
hai04310  Wnt signaling pathway
hai04512  ECM-receptor interaction
hai04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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