KEGG   PATHWAY: loc04810
Entry
loc04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Lepisosteus oculatus (spotted gar)
Class
Cellular Processes; Cell motility
Pathway map
loc04810  Regulation of actin cytoskeleton
loc04810

Other DBs
GO: 0030036
Organism
Lepisosteus oculatus (spotted gar) [GN:loc]
Gene
102692058  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
102697034  lpar2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
102695093  lysophosphatidic acid receptor 4-like [KO:K04275]
102695965  lysophosphatidic acid receptor 6-like [KO:K04275]
102692207  lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
102693787  lysophosphatidic acid receptor 6-like [KO:K04275]
102693349  cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102684223  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
102695044  prothrombin-like [KO:K01313] [EC:3.4.21.5]
102698385  prothrombin-like [KO:K01313] [EC:3.4.21.5]
102697669  proteinase-activated receptor 1-like [KO:K03914]
102697478  proteinase-activated receptor 1-like isoform X1 [KO:K03914]
102697280  proteinase-activated receptor 1-like [KO:K03914]
102694874  insulin-like [KO:K04526]
102695073  insulin-like isoform X2 [KO:K04526]
102689722  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
102692817  fgf1; fibroblast growth factor 1 [KO:K18496]
102692334  fgf2; fibroblast growth factor 2 [KO:K18497]
107079423  fibroblast growth factor 4A-like isoform X1 [KO:K04358]
102688224  fgf5; fibroblast growth factor 5 [KO:K04358]
102688700  fgf10; fibroblast growth factor 10 [KO:K04358]
102693875  fgf9; fibroblast growth factor 9 isoform X2 [KO:K04358]
102686248  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102690321  fgf7; fibroblast growth factor 7 [KO:K04358]
102686339  fibroblast growth factor 18-like [KO:K04358]
102686735  fibroblast growth factor 18-like isoform X3 [KO:K04358]
102684714  fgf20; fibroblast growth factor 20 [KO:K04358]
102686442  fgf22; fibroblast growth factor 22 [KO:K04358]
102682504  fgf8; fibroblast growth factor 8 [KO:K04358]
102688212  fgf4; fibroblast growth factor 4 [KO:K04358]
102689763  fgf3; fibroblast growth factor 3 [KO:K04358]
102689601  fgf16; fibroblast growth factor 16 [KO:K04358]
102696329  fgf6; fibroblast growth factor 6 [KO:K04358]
102689566  fibroblast growth factor 19-like [KO:K22603]
102685904  fibroblast growth factor 19-like [KO:K22603]
102686213  fgf23; fibroblast growth factor 23 [KO:K22428]
102685958  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102694666  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
102688904  pdgfc; platelet-derived growth factor C isoform X2 [KO:K05450]
102688253  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102691524  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102694148  fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
102691474  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102687082  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102682229  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102697036  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102684349  fn1; fibronectin isoform X1 [KO:K05717]
102685990  itga1; integrin alpha-1 [KO:K06480]
102686190  itga2; integrin alpha-2 [KO:K06481]
102688191  itga2b; integrin alpha-IIb [KO:K06476]
102689009  itga3; integrin alpha-3 isoform X1 [KO:K06482]
102682247  itga4; integrin alpha-4 [KO:K06483]
102694002  itga5; integrin alpha-5 [KO:K06484]
102689276  itga6; integrin alpha-6 isoform X1 [KO:K06485]
102695191  itga7; integrin alpha-7 isoform X1 [KO:K06583]
102684864  itga8; integrin alpha-8 [KO:K06584]
102687777  itga9; integrin alpha-9 [KO:K06585]
102698250  itga10; integrin alpha-10 [KO:K06586]
102690666  itga11; integrin alpha-11 [KO:K06587]
102684077  itgav; integrin alpha-V isoform X1 [KO:K06487]
102690798  itgal; integrin alpha-L [KO:K05718]
107079925  itgae; integrin alpha-E isoform X1 [KO:K06524]
102687195  itgb1; integrin beta-1 isoform X2 [KO:K05719]
102690489  itgb2; integrin beta-2 [KO:K06464]
102687246  itgb3; integrin beta-3 [KO:K06493]
102696979  itgb4; integrin beta-4 isoform X1 [KO:K06525]
102690279  itgb5; integrin beta-5 [KO:K06588]
102694560  itgb6; integrin beta-6 isoform X1 [KO:K06589]
102696565  itgb7; integrin beta-7 [KO:K06590]
102695741  itgb8; integrin beta-8 [KO:K06591]
102695287  kininogen-1-like [KO:K03898]
102683382  B2 bradykinin receptor-like [KO:K03916]
102683590  bdkrb2; B2 bradykinin receptor [KO:K03916]
102697130  chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
102697102  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
102696792  chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
102692176  chrm4; muscarinic acetylcholine receptor M4 isoform X1 [KO:K04132]
102689322  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
102692241  c5; complement C5 [KO:K03994]
102692262  c6; complement component C6 [KO:K03995]
102692464  c7; complement component C7 [KO:K03996]
102696134  c8a; complement component C8 alpha chain [KO:K03997]
102696332  c8b; complement component C8 beta chain isoform X1 [KO:K03998]
107076693  c8g; complement component C8 gamma chain [KO:K03999]
102695378  c9; complement component C9 [KO:K04000]
102693638  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102687288  gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102697527  fgd1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
102693690  fgd3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
102692374  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
102683891  adapter molecule crk-like [KO:K04438]
102695616  crkl; crk-like protein [KO:K04438]
102690670  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102697324  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102692301  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102696513  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102697398  hras; GTPase HRas [KO:K02833]
102696189  kras; GTPase KRas isoform X3 [KO:K07827]
102691327  nras; GTPase NRas [KO:K07828]
102690777  rras2; ras-related protein R-Ras2 [KO:K07830]
102687237  mras; ras-related protein M-Ras [KO:K07831]
102693427  arhgef6; rho guanine nucleotide exchange factor 6 isoform X2 [KO:K05729]
102691786  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102685070  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102688673  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102695429  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102693436  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102696821  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
102687995  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
102692646  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
102683314  vav1; proto-oncogene vav isoform X1 [KO:K05730]
102685871  vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102696827  tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
102687735  LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
102693824  braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102692545  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102695470  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102691532  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102686784  map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102683764  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102690433  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102684446  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102691207  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102697254  rgcc; regulator of cell cycle RGCC [KO:K26108]
102685398  regulator of cell cycle RGCC-like [KO:K26108]
102698314  rho guanine nucleotide exchange factor 1-like [KO:K12330]
102684494  arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
102689375  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
102686749  transforming protein RhoA-like [KO:K04513]
102689455  rhoc; rho-related GTP-binding protein RhoC [KO:K04513]
102682211  rho-related GTP-binding protein RhoA-C [KO:K04513]
102696469  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102692563  rac2; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102686683  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102683416  cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
102698253  cell division control protein 42 homolog [KO:K04393]
102692188  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102683467  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102691808  pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102689711  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
102699066  pak7; serine/threonine-protein kinase PAK 7 isoform X2 [KO:K05736] [EC:2.7.11.1]
102692005  pak6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102698447  arhgef7; rho guanine nucleotide exchange factor 7 isoform X2 [KO:K13710]
102695106  git1; ARF GTPase-activating protein GIT1 [KO:K05737]
102698697  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102688837  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102682466  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102686027  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
102685356  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102689935  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102697050  mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
102683699  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102699172  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102696354  serine/threonine-protein phosphatase PP1(5.9)-like [KO:K06269] [EC:3.1.3.16]
102686196  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
102682260  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102688760  myl5; myosin light chain 5 [KO:K12753]
102697662  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102694319  myosin regulatory light polypeptide 9 [KO:K12755]
102688000  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
102691547  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
102690979  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
102698361  myosin-11-like isoform X1 [KO:K10352]
102695864  myh10; myosin-10 isoform X4 [KO:K10352]
102692295  myh9; myosin-9 [KO:K10352]
102689729  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
102687426  slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
102698309  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
102686521  pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
102690642  pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
102687138  pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
102687177  pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X2 [KO:K00920] [EC:2.7.1.149]
102690135  pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X4 [KO:K00920] [EC:2.7.1.149]
102698842  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
102697125  limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
102690924  LIM domain kinase 2-like [KO:K05744] [EC:2.7.11.1]
102697124  limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102697182  diaph3; protein diaphanous homolog 3 isoform X2 [KO:K05745]
102689798  diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05745]
102686308  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
102692088  baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4 [KO:K05627]
102683087  enah; protein enabled homolog [KO:K05746]
102690945  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
102694009  wasf2; wiskott-Aldrich syndrome protein family member 2 isoform X2 [KO:K05748]
102693845  cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102694547  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X2 [KO:K05749]
102684224  nckap1; nck-associated protein 1 isoform X3 [KO:K05750]
102690061  nckap1l; nck-associated protein 1-like [KO:K05750]
102686076  abi2; abl interactor 2 isoform X3 [KO:K05751]
102692606  brk1; protein BRICK1 [KO:K05752]
102686997  wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X3 [KO:K05753]
102687047  actr2; actin-related protein 2 isoform X2 [KO:K17260]
102691032  actr3; actin-related protein 3 [KO:K18584]
102684217  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
102694828  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
102695161  actin-related protein 2/3 complex subunit 1A [KO:K05757]
102684806  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
102697902  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102694512  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102691400  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102689021  arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102685870  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102690749  actg1; actin, cytoplasmic 2 [KO:K05692]
102696204  actb; actin, cytoplasmic 1 [KO:K05692]
102687042  pfn2; profilin-2 isoform X1 [KO:K05759]
102696122  pfn3; profilin-3 [KO:K05759]
102696490  pfn4; profilin-4 [KO:K05759]
102689346  pxn; paxillin [KO:K05760]
102697135  ezr; ezrin isoform X2 [KO:K08007]
102682335  rdx; radixin [KO:K05762]
102686549  msn; moesin isoform X1 [KO:K05763]
102682393  tmsb4x; thymosin beta-4 [KO:K05764]
102687759  thymosin beta-12-like isoform X1 [KO:K05764]
102683678  cofilin-2-like [KO:K05765]
102683042  cfl2; cofilin-2 isoform X2 [KO:K05765]
102693264  cfl1; cofilin-1 [KO:K05765]
102695500  ssh2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102695364  ssh1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102691417  ssh3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102691737  vcl; LOW QUALITY PROTEIN: vinculin [KO:K05700]
102698473  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
102687813  iqgap2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
102693786  ras GTPase-activating-like protein IQGAP3 [KO:K05767]
102690448  gelsolin-like [KO:K05768]
102692765  scin; adseverin [KO:K05768]
102685566  gsn; gelsolin isoform X2 [KO:K05768]
102686150  adseverin-like [KO:K05768]
102688291  alpha-actinin-4 [KO:K05699]
102693222  alpha-actinin-1 [KO:K05699]
102693649  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
102695054  apc; adenomatous polyposis coli protein isoform X3 [KO:K02085]
102683642  spata13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
102698236  arhgef4; rho guanine nucleotide exchange factor 4 isoform X9 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
loc04010  MAPK signaling pathway
loc04510  Focal adhesion
loc04520  Adherens junction
KO pathway
ko04810   
LinkDB

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