KEGG   PATHWAY: nmel04510
Entry
nmel04510                   Pathway                                
Name
Focal adhesion - Numida meleagris (helmeted guineafowl)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nmel04510  Focal adhesion
nmel04510

Other DBs
GO: 0005925
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110394035  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110388398  collagen alpha-1(I) chain-like [KO:K06236]
110390877  COL2A1; collagen alpha-1(II) chain [KO:K19719]
110403266  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
110403268  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
110398034  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
110398035  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
110407454  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
110407460  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
110399529  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
110399575  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110394081  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
110400425  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
110408071  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
110396978  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
110387441  collagen alpha-2(IX) chain isoform X1 [KO:K08131]
110393606  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
110396190  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
110408008  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
110393896  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
110395980  LAMA4; laminin subunit alpha-4 [KO:K06241]
110392386  LAMB1; laminin subunit beta-1 [KO:K05636]
110404947  laminin subunit beta-2-like isoform X1 [KO:K06243]
110404948  laminin subunit beta-2-like [KO:K06243]
110388297  LAMB3; laminin subunit beta-3 [KO:K06244]
110392388  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
110402436  LAMC1; laminin subunit gamma-1 [KO:K05635]
110402437  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
110406737  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
110407333  CHAD; chondroadherin [KO:K06248]
110392355  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110401369  THBS1; thrombospondin-1 [KO:K16857]
110396493  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
110388912  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
110390104  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
110399842  FN1; fibronectin isoform X1 [KO:K05717]
110398229  SPP1; osteopontin [KO:K06250]
110407581  VTN; vitronectin [KO:K06251]
110406891  TNC; tenascin isoform X1 [KO:K06252]
110402416  TNR; tenascin-R [KO:K06252]
110402417  TNN; tenascin-N [KO:K06252]
110397366  VWF; von Willebrand factor isoform X1 [KO:K03900]
110398859  IBSP; bone sialoprotein 2 isoform X1 [KO:K06253]
110389587  ITGA1; integrin alpha-1 [KO:K06480]
110389638  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
110388403  integrin alpha-3-like [KO:K06482]
110399450  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
110400360  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
110391114  ITGA7; integrin alpha-7 [KO:K06583]
110394492  ITGA8; integrin alpha-8 [KO:K06584]
110393412  ITGA9; integrin alpha-9 [KO:K06585]
110403915  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
110400462  ITGAV; integrin alpha-V [KO:K06487]
110393676  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
110388544  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
110407291  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
110400372  ITGB5; integrin beta-5 [KO:K06588]
110399659  ITGB6; integrin beta-6 [KO:K06589]
110390876  ITGB7; integrin beta-7 [KO:K06590]
110393691  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
110405836  EMP2; epithelial membrane protein 2 [KO:K26256]
110405632  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110392622  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
110397304  PDGFC; platelet-derived growth factor C [KO:K05450]
110389823  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110399042  EGF; pro-epidermal growth factor [KO:K04357]
110393921  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110395890  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110401232  PGF; placenta growth factor isoform X1 [KO:K16859]
110404988  VEGFD; vascular endothelial growth factor D [KO:K05449]
110398494  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
110392449  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110397725  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110405265  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110403525  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110398187  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
110393050  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110403438  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
110388861  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
110405266  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110392601  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110388649  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110388234  EMP1; epithelial membrane protein 1 [KO:K26255]
110408003  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
110391622  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
110401122  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
110404968  RHOA; transforming protein RhoA [KO:K04513]
110393351  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110395385  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
110406487  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110408206  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
110407950  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
110394232  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
110394311  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
110400859  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110396314  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110406337  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110392872  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
110388357  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
110391351  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
110388525  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
110393482  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110400604  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110408280  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110404229  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110388874  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
110388035  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110389787  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
110407139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110403650  actin, cytoplasmic type 5 [KO:K05692]
110406159  ACTB; actin, cytoplasmic 1 [KO:K05692]
110403677  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
110395702  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
110402069  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
110389118  ACTN4; alpha-actinin-4 [KO:K05699]
110403643  TLN2; talin-2 isoform X1 [KO:K06271]
110389621  TLN1; talin-1 isoform X1 [KO:K06271]
110404616  FLNB; filamin-B isoform X1 [KO:K27392]
110406215  PXN; paxillin isoform X1 [KO:K05760]
110391748  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
110398164  ZYX; LOW QUALITY PROTEIN: zyxin [KO:K06273]
110400515  VCL; vinculin isoform X1 [KO:K05700]
110401102  PARVA; alpha-parvin isoform X1 [KO:K06275]
110396865  PARVB; beta-parvin isoform X1 [KO:K06275]
110396882  PARVG; gamma-parvin [KO:K06275]
110405647  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110396620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110400745  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110399222  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
110395154  CTNNB1; catenin beta-1 [KO:K02105]
110407228  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110405777  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110393818  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110398160  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110397252  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110408755  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110389564  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110388756  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110402756  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110390505  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110391240  proto-oncogene vav-like [KO:K05730]
110402414  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110406776  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
110405694  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110393190  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110407289  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110391291  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110397348  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
110403309  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
110389111  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110395539  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
110401184  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
110408527  CDC42; cell division control protein 42 homolog [KO:K04393]
110404454  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
110406265  CRKL; crk-like protein [KO:K04438]
110407619  CRK; adapter molecule crk isoform X1 [KO:K04438]
110400523  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
110406774  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
110388047  RAP1A; ras-related protein Rap-1A [KO:K04353]
110392786  RAP1B; ras-related protein Rap-1b [KO:K07836]
110398630  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110405490  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110399325  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110402812  JUN; transcription factor AP-1 [KO:K04448]
110394457  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110392605  CAV1; caveolin-1 [KO:K06278]
110392606  CAV2; caveolin-2 [KO:K12958]
110404959  CAV3; caveolin-3 [KO:K12959]
110397033  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
110391258  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110389019  SHC2; SHC-transforming protein 2 [KO:K17447]
110390178  SHC3; SHC-transforming protein 3 [KO:K17448]
110403695  SHC4; SHC-transforming protein 4 [KO:K17449]
110407421  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110401960  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110397177  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110400761  HRAS; GTPase HRas [KO:K02833]
110404723  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110404031  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110406180  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110400907  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
110390646  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110388224  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110389900  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
110403244  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
110395041  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
nmel04010  MAPK signaling pathway
nmel04060  Cytokine-cytokine receptor interaction
nmel04070  Phosphatidylinositol signaling system
nmel04110  Cell cycle
nmel04310  Wnt signaling pathway
nmel04512  ECM-receptor interaction
nmel04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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