KEGG   PATHWAY: nvs05208
Entry
nvs05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Neogale vison (American mink)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05208

Organism
Neogale vison (American mink) [GN:nvs]
Gene
122901073  AS3MT; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
122918402  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
122919175  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
122898785  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
122891708  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
122899711  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
122900299  glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
122900300  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
122901094  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
122901095  glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
122902020  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
122909124  LOW QUALITY PROTEIN: glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122909140  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
122909151  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
122903212  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
122903213  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
122903214  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
122903215  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
122917705  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
14841852  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
14841840  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
14841846  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
14841848  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
14841847  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
14841849  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
14841850  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
122913194  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
122903032  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
122908267  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
122897149  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
122915592  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
122890557  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
122911678  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
122904860  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
122897372  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
122891482  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
122894691  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
122903641  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
122905031  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
122891864  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
122909803  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
122917290  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
122891108  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
122902465  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
122895608  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
122909833  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
122891747  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
122909517  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
122894479  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
122905137  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
122902186  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
122908543  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
122909800  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
122908719  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
122917534  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
122909545  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
122901022  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
122904311  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
122896181  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
122897625  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
122902230  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
122918373  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
122912907  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
122894329  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
122897039  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
122906214  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
122899787  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
122908823  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
122896151  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
122909951  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
122913199  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
122919183  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
122892467  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
122903016  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
122912547  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
122896387  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
122899501  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
122918379  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
122910054  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
122912281  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
122910115  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
122911488  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
14841851  CYTB; cytochrome b [KO:K00412]
122904230  cytochrome c1, heme protein, mitochondrial [KO:K00413]
122909454  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
122895793  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
122899923  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
122889565  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122899957  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122892438  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122904422  cytochrome b-c1 complex subunit 7 [KO:K00417]
122889942  cytochrome b-c1 complex subunit 8-like [KO:K00418]
122891839  cytochrome b-c1 complex subunit 8 [KO:K00418]
122902031  cytochrome b-c1 complex subunit 9 [KO:K00419]
122909942  cytochrome b-c1 complex subunit 10 [KO:K00420]
14841845  COX3; cytochrome c oxidase subunit III [KO:K02262]
14841841  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
14841842  COX2; cytochrome c oxidase subunit II [KO:K02261]
122915598  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
122911162  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
122893690  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
122915687  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
122894239  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
122895433  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
122903357  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
122912869  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
122891980  cytochrome c oxidase subunit 6B1-like [KO:K02267]
122913938  cytochrome c oxidase subunit 6B2 [KO:K02267]
122911559  cytochrome c oxidase subunit 6B1 [KO:K02267]
122896390  cytochrome c oxidase subunit 6C [KO:K02268]
122914073  cytochrome c oxidase subunit 6C-like [KO:K02268]
122905394  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
122897493  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122915125  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
122903450  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122911585  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
122897159  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
122889784  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
122900125  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
122897479  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122910059  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122917769  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
122914556  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
122902906  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
122891405  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
122890845  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
122909967  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
122906212  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
122901826  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
122915928  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
122904096  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
14841844  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
122900323  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
122896727  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
122896778  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
122906610  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
122891642  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
122908798  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
122902615  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
122906004  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
122900900  ATP synthase subunit d, mitochondrial-like [KO:K02138]
122908319  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
122896797  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
122896839  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
122908364  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
14841843  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
122902858  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
122904870  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
122891745  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122900317  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
122900818  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122889854  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122889978  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
122897566  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
122890114  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
122916940  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
122896262  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
122900832  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
122908345  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
122912833  CAT; catalase [KO:K03781] [EC:1.11.1.6]
122919132  SLC26A1; sulfate anion transporter 1 [KO:K14700]
122894140  SLC26A2; sulfate transporter [KO:K14701]
122909450  solute carrier family 26 member 6-like isoform X1 [KO:K14704]
122918853  SLC26A9; solute carrier family 26 member 9 isoform X1 [KO:K14706]
122893016  cytochrome P450 1A2-like isoform X1 [KO:K07409] [EC:1.14.14.1]
122899062  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
122912053  cytochrome P450 2F5 isoform X1 [KO:K07416] [EC:1.14.14.1]
122893452  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
122915146  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
122918688  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
122889650  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
122910723  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
122900192  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
122899906  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
122891768  AKR1C4; aldo-keto reductase family 1 member C4 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
122911291  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
122908308  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
122908309  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
122908310  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
122904876  AHR; aryl hydrocarbon receptor [KO:K09093]
122907702  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
122912502  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
122911145  cytochrome b-245 light chain [KO:K08009]
122896781  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
122895759  NCF1; neutrophil cytosol factor 1 [KO:K08011]
122918609  NCF2; neutrophil cytosol factor 2 [KO:K08010]
122889261  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
122904647  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122904762  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122905007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122905991  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122915138  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122894274  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122913220  HRAS; GTPase HRas isoform X1 [KO:K02833]
122892446  KRAS; GTPase KRas isoform X1 [KO:K07827]
122899136  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
122900359  NRAS; GTPase NRas [KO:K07828]
122897579  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122905138  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122909192  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122892965  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122909871  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122895342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122903200  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122906270  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122906771  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122909795  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122889452  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122900866  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122915651  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122891909  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122891975  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122910068  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
122910086  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122900023  JUN; transcription factor AP-1 [KO:K04448]
122893478  FOS; proto-oncogene c-Fos [KO:K04379]
122918946  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122899916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122909588  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122899425  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122908712  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122908899  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122895963  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122895932  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122918524  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122912036  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122894172  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122904039  FOXO3; forkhead box protein O3 [KO:K09408]
122913061  BAD; bcl2-associated agonist of cell death [KO:K02158]
122915978  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
122900668  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122901015  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122889856  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122897563  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122893621  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
122913121  RELA; transcription factor p65 [KO:K04735]
122889330  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122909342  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
122912912  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
122915349  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
122895388  low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
122903412  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
122916091  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
122917157  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
122918641  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
122911916  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
122915151  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
122894310  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
122904271  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122906672  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
122908696  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
122906116  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
122894188  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
122900431  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
122901177  VEGFA; vascular endothelial growth factor A [KO:K05448]
122909732  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
122902626  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
122891620  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Redox toxicology of environmental chemicals causing oxidative stress.
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Related
pathway
nvs00190  Oxidative phosphorylation
nvs00980  Metabolism of xenobiotics by cytochrome P450
nvs04010  MAPK signaling pathway
nvs04064  NF-kappa B signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04151  PI3K-Akt signaling pathway
nvs04370  VEGF signaling pathway
nvs05207  Chemical carcinogenesis - receptor activation
nvs05211  Renal cell carcinoma
nvs05215  Prostate cancer
nvs05219  Bladder cancer
nvs05221  Acute myeloid leukemia
nvs05222  Small cell lung cancer
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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