KEGG   PATHWAY: pale05205
Entry
pale05205                   Pathway                                
Name
Proteoglycans in cancer - Pteropus alecto (black flying fox)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
pale05205  Proteoglycans in cancer
pale05205

Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102893320  CD44; CD44 antigen [KO:K06256]
102891249  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
102884070  CTTN; src substrate cortactin isoform X2 [KO:K06106]
102885301  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
102885300  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102878822  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102883521  VAV1; proto-oncogene vav [KO:K05730]
102886772  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102884766  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102895590  KRAS; GTPase KRas isoform X1 [KO:K07827]
102885950  NRAS; GTPase NRas isoform X2 [KO:K07828]
102881941  RRAS; ras-related protein R-Ras [KO:K07829]
102881508  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102879891  MRAS; ras-related protein M-Ras [KO:K07831]
102878393  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102893439  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102877877  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102879034  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102888464  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
102889114  CDC42; cell division control protein 42 homolog [KO:K04393]
102878877  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102877910  ESR1; estrogen receptor isoform X1 [KO:K08550]
102885330  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102884158  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102884469  ACTB; actin, cytoplasmic 1 [KO:K05692]
102889996  FLNA; filamin-A isoform X1 [KO:K04437]
102880323  PAK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102883973  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
102894194  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
102891515  RHOA; transforming protein RhoA [KO:K04513]
102879861  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
102897424  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
102880607  ANK2; LOW QUALITY PROTEIN: ankyrin-2 [KO:K09255]
102886179  ANK3; ankyrin-3 isoform X1 [KO:K09259]
102881252  GAB1; GRB2-associated-binding protein 1 isoform X6 [KO:K09593]
102889227  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102880320  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102889576  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102879163  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102891637  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102879453  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102888463  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102892254  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102881448  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102887827  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102898474  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
102879733  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
102878573  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102879072  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
102898319  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102894982  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102896356  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102881783  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102888982  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
102888385  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102880869  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
102896030  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102879419  NANOG; homeobox protein NANOG isoform X1 [KO:K10164]
102895749  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
102895564  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
102884374  STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692]
102896776  TWIST2; twist-related protein 2 [KO:K09069]
102892258  TWIST1; twist-related protein 1 [KO:K09069]
102890186  HOXD10; homeobox protein Hox-D10 [KO:K09295]
102886864  DCN; decorin [KO:K04660]
102890331  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102885962  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102885092  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102896950  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102891214  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102889369  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102890117  EIF4B; eukaryotic translation initiation factor 4B isoform X5 [KO:K03258]
102891633  RPS6; 40S ribosomal protein S6 [KO:K02991]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102886570  CAV1; caveolin-1 isoform X1 [KO:K06278]
102887161  CAV2; caveolin-2 [KO:K12958]
102879431  CAV3; caveolin-3 [KO:K12959]
102891206  CD63; CD63 antigen [KO:K06497]
102894049  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102897289  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102884154  TGFB1; transforming growth factor beta-1 [KO:K13375]
102893057  TLR2; toll-like receptor 2 precursor [KO:K10159]
102897365  TLR4; toll-like receptor 4 precursor [KO:K10160]
102882502  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
102887632  TNF; tumor necrosis factor [KO:K03156]
102884214  IL12B; interleukin-12 subunit beta [KO:K05425]
102895392  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102895574  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102895524  MYC; myc proto-oncogene protein [KO:K04377]
102880017  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
102897284  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102885005  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
102890394  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
102896638  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102885990  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102895335  CBL; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
102881388  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
102898784  THBS1; thrombospondin-1 [KO:K16857]
102883808  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
102889517  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102886614  LUM; lumican [KO:K08122]
102883204  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102879561  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
102884281  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
102889604  TP53; cellular tumor antigen p53 [KO:K04451]
102881295  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
102893928  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
102888805  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
102881775  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
102879325  SDC1; syndecan-1 [KO:K06257]
102880095  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
102886320  PLAUR; LOW QUALITY PROTEIN: urokinase plasminogen activator surface receptor [KO:K03985]
102886463  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102878069  COL1A2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
102897185  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102886785  ITGB1; integrin beta-1 [KO:K05719]
102878956  VTN; vitronectin [KO:K06251]
102895440  ITGAV; integrin alpha-V [KO:K06487]
102881894  ITGB3; integrin beta-3 [KO:K06493]
102891509  FN1; fibronectin isoform X1 [KO:K05717]
102892062  ITGB5; integrin beta-5 [KO:K06588]
102884470  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102888016  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102880538  FZD7; frizzled-7 [KO:K02432]
102895634  FZD1; frizzled-1 [KO:K02432]
102884150  FZD2; frizzled-2 [KO:K02235]
102890038  FZD3; frizzled-3 isoform X1 [KO:K02329]
102892989  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
102877864  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
102883426  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
102890002  FZD6; frizzled-6 [KO:K02376]
102894135  FZD10; frizzled-10 [KO:K02842]
102878169  FZD9; frizzled-9 [KO:K02842]
102889111  ITGA5; integrin alpha-5 [KO:K06484]
102898100  SDC2; syndecan-2 [KO:K16336]
102897360  EZR; ezrin [KO:K08007]
102898450  RDX; radixin isoform X1 [KO:K05762]
102879953  MSN; moesin [KO:K05763]
102882587  SDC4; syndecan-4 [KO:K16338]
107196088  FGF2; fibroblast growth factor 2 [KO:K18497]
102898943  FGFR1; fibroblast growth factor receptor 1 isoform X9 [KO:K04362] [EC:2.7.10.1]
102885879  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
102889219  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102887205  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102882462  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102889597  SOS2; son of sevenless homolog 2 [KO:K03099]
102896228  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102883128  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102880663  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102888961  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102881206  NUDT16L1; tudor-interacting repair regulator protein isoform X2 [KO:K16867]
102891920  PXN; paxillin isoform X2 [KO:K05760]
102898998  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
102882842  HBEGF; proheparin-binding EGF-like growth factor isoform X1 [KO:K08523]
102884911  GPC1; LOW QUALITY PROTEIN: glypican-1 [KO:K08107]
102880410  IGF2; insulin-like growth factor II [KO:K13769]
102890682  GPC3; glypican-3 [KO:K08109]
102880959  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
102885080  WNT2; protein Wnt-2 [KO:K00182]
102895795  WNT3A; protein Wnt-3a [KO:K00312]
102877979  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102888866  WNT4; protein Wnt-4 [KO:K00408]
102890342  WNT5A; protein Wnt-5a isoform X5 [KO:K00444]
102881682  WNT5B; protein Wnt-5b isoform X2 [KO:K00444]
102882368  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
102888597  WNT7A; protein Wnt-7a [KO:K00572]
102898026  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
102896480  WNT8A; protein Wnt-8a [KO:K00714]
102878209  WNT8B; protein Wnt-8b [KO:K00714]
102885223  protein Wnt-9b [KO:K01064]
102884543  WNT9A; protein Wnt-9a [KO:K01064]
102882121  WNT10A; protein Wnt-10a [KO:K01357]
102888263  WNT10B; protein Wnt-10b [KO:K01357]
102877879  WNT11; protein Wnt-11 [KO:K01384]
102882050  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
102882514  SHH; sonic hedgehog protein [KO:K11988]
102883197  IHH; indian hedgehog protein [KO:K11989]
102884350  PTCH1; LOW QUALITY PROTEIN: protein patched homolog 1 [KO:K06225]
102892668  SMO; smoothened homolog [KO:K06226]
102887886  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
102893228  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102882918  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102886679  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102877853  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102895900  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102888602  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102888845  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102877720  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102887333  HSPB2; heat shock protein beta-2 [KO:K09543]
102895931  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
pale04010  MAPK signaling pathway
pale04020  Calcium signaling pathway
pale04066  HIF-1 signaling pathway
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04210  Apoptosis
pale04310  Wnt signaling pathway
pale04340  Hedgehog signaling pathway
pale04350  TGF-beta signaling pathway
pale04370  VEGF signaling pathway
pale04510  Focal adhesion
pale04520  Adherens junction
pale04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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