KEGG   PATHWAY: pcoo05014
Entry
pcoo05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Puma concolor (puma)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pcoo05014  Amyotrophic lateral sclerosis
pcoo05014

Organism
Puma concolor (puma) [GN:pcoo]
Gene
112856999  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
112867264  BID; BH3-interacting domain death agonist [KO:K04726]
112868295  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
112869207  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112852108  BAD; bcl2-associated agonist of cell death [KO:K02158]
112863492  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
112870556  cytochrome c-like [KO:K08738]
112866368  cytochrome c, testis-specific-like [KO:K08738]
112866541  cytochrome c [KO:K08738]
112861739  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112870035  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112849351  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
11473378  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
11473379  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
11473385  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
11473377  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
11473386  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
11473374  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
11473375  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
112852033  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
112868105  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
112850447  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
112871256  NDUFA1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112859395  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
112861044  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
112851148  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
112863770  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112866744  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112850499  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
112866670  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
112863619  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112871796  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112867527  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112867674  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112853284  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112852859  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112863598  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112852861  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112856171  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112866888  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112848529  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112850222  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112849670  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
112861170  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
112854315  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
112859401  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
112853318  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
112870588  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112869732  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
112851625  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112865371  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112860962  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
112872093  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112861125  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112852781  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112851977  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
112858442  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112865346  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
112860213  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112871838  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112851739  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112865224  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
112860597  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
112850981  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
11473376  CYTB; cytochrome b [KO:K00412]
112859467  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112852534  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112853229  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112869979  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112859521  cytochrome b-c1 complex subunit 7 [KO:K00417]
112861315  cytochrome b-c1 complex subunit 8 [KO:K00418]
112870212  cytochrome b-c1 complex subunit 9 [KO:K00419]
11473384  COX3; cytochrome c oxidase subunit III [KO:K02262]
11473380  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
11473381  COX2; cytochrome c oxidase subunit II [KO:K02261]
112869546  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
112857357  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112855929  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112868931  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112857263  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112870298  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112851056  cytochrome c oxidase subunit 6B1 [KO:K02267]
112871161  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112853181  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112859438  cytochrome c oxidase subunit 6C [KO:K02268]
112862079  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112864047  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
112870951  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112858534  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
112868518  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112869381  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112852040  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112868376  ATP5F1A; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
112863809  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
112867261  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
112852776  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
112851812  ATP5F1E; LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial [KO:K02135]
11473383  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
112869166  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112871780  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112854094  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112867188  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112864643  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
112849519  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
112849583  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
11473382  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
112861387  VDAC1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
112851624  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
112854508  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
112862120  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
112862211  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
112867769  OPTN; optineurin isoform X1 [KO:K19946]
112861403  SQSTM1; sequestosome-1 [KO:K14381]
112868813  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
112863123  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
112863216  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
112863806  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112848671  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
112861229  WDR41; WD repeat-containing protein 41 [KO:K23610]
112857149  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
112849476  CUNH9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
112852617  RAB8A; ras-related protein Rab-8A [KO:K07901]
112871186  RAB39B; ras-related protein Rab-39B [KO:K07925]
112869149  RAB1A; ras-related protein Rab-1A [KO:K07874]
112848905  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112857056  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
112867375  ATG101; autophagy-related protein 101 [KO:K19730]
112864915  ATG13; autophagy-related protein 13 [KO:K08331]
112859628  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
112865154  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
112863210  BECN2; beclin-2 [KO:K08334]
112853991  BECN1; beclin-1 [KO:K08334]
112849662  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
112856175  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
112854526  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
112868128  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
112855877  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
112851920  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
112864581  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
112859970  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
112868570  ALS2; alsin [KO:K04575]
112850392  RAB5A; ras-related protein Rab-5A [KO:K07887]
112859959  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112849489  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
112862088  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
112856502  SPG11; spatacsin isoform X1 [KO:K19026]
112869884  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
112858792  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
112854258  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112861555  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112869328  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112868721  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
112851696  UBQLN4; ubiquilin-4 [KO:K04523]
112871069  UBQLN2; ubiquilin-2 isoform X1 [KO:K04523]
112865558  UBQLN3; ubiquilin-3 [KO:K04523]
112871974  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
112859784  DERL1; derlin-1 isoform X1 [KO:K11519]
112856001  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
112866596  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
112854962  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
112868273  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
112871938  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
112855103  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
112857090  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
112858694  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
112854106  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
112871747  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
112855220  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
112849269  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
112870973  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
112866304  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
112856402  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
112850709  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
112856484  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
112865190  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
112864552  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
112850215  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
112872149  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
112854113  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
112870279  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
112864467  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
112852693  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
112852521  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
112857328  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
112851991  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
112871860  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
112870755  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
112851286  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
112862736  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
112870931  HDAC6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
112871779  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
112856824  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
112855510  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112862171  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112868559  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112868792  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112855729  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112871194  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
112867380  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
112866868  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
112856450  ATXN2L; ataxin-2-like protein [KO:K23625]
112870122  ATXN2; ataxin-2 [KO:K23625]
112860656  MATR3; matrin-3 [KO:K13213]
112855115  ANG; angiogenin [KO:K16631] [EC:3.1.27.-]
112866831  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
112861961  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112868776  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
112870711  nuclear RNA export factor 3-like [KO:K14284]
112870713  nuclear RNA export factor 2-like [KO:K14284]
112870715  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112851890  NXF1; nuclear RNA export factor 1 [KO:K14284]
112869227  NXT1; NTF2-related export protein 1 [KO:K14285]
112871231  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
112863617  GLE1; nucleoporin GLE1 [KO:K18723]
112857817  TPR; nucleoprotein TPR [KO:K09291]
112863522  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
112853627  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
112865263  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
112868961  RAE1; mRNA export factor [KO:K14298]
112858369  SEC13; LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
112868248  SEH1L; nucleoporin SEH1 [KO:K14299]
112851539  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
112863603  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
112863638  NUP37; nucleoporin Nup37 [KO:K14302]
112865182  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
112864557  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
112862486  NUP43; nucleoporin Nup43 [KO:K14305]
112850819  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
112870684  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
112861164  NUP58; nucleoporin p58/p45 [KO:K14307]
112858351  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
112857495  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
112866674  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
112850011  NUP188; nucleoporin NUP188 homolog [KO:K14311]
112860978  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
112870334  NUP35; nucleoporin NUP35 [KO:K14313]
112851724  NUP210L; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like [KO:K14314]
112858025  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
112872012  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
112859901  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
112849811  NUP214; nuclear pore complex protein Nup214 [KO:K14317]
112856965  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
112871908  SETX; probable helicase senataxin [KO:K10706] [EC:5.6.2.5 5.6.2.3]
112870174  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
112850502  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
112868966  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
112864801  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
112863246  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112864460  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
112870154  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
112860577  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112862885  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112865165  caspase-12-like [KO:K04741] [EC:3.4.22.-]
112864237  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112855314  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112863930  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112862849  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112872079  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
112853630  TNF; tumor necrosis factor [KO:K03156]
112867910  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112861663  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
112862436  DAXX; death domain-associated protein 6 [KO:K02308]
112857077  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112864599  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112862836  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112862837  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
112863384  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112870473  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
112852050  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
112855390  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
112853045  GPX1; glutathione peroxidase 1 isoform X1 [KO:K00432] [EC:1.11.1.9]
112853501  LOW QUALITY PROTEIN: epididymal secretory glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
112853503  glutathione peroxidase 6-like [KO:K00432] [EC:1.11.1.9]
112860335  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
112860497  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
112848537  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
112865557  CAT; catalase [KO:K03781] [EC:1.11.1.6]
112867233  PRPH; peripherin isoform X1 [KO:K07607]
112869976  NEFM; neurofilament medium polypeptide [KO:K04573]
112870413  NEFH; neurofilament heavy polypeptide [KO:K04574]
112861515  PFN3; profilin-3 [KO:K05759]
112849669  PFN2; profilin-2 isoform X1 [KO:K05759]
112864340  PFN4; profilin-4 [KO:K05759]
112870752  profilin-1-like [KO:K05759]
112864619  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112860092  ACTB; actin, cytoplasmic 1 [KO:K05692]
112854564  ANXA11; annexin A11 [KO:K17095]
112854878  ANXA7; annexin A7 isoform X1 [KO:K17095]
112848974  KIF5C; kinesin heavy chain [KO:K10396]
112863775  KIF5A; kinesin heavy chain [KO:K10396]
112867749  KIF5B; kinesin-1 heavy chain [KO:K10396]
112855198  KLC1; kinesin light chain 1 [KO:K10407]
112862004  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
112851001  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
112852008  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
112870317  tubulin alpha-3 chain [KO:K07374]
112857710  tubulin alpha chain-like [KO:K07374]
112872268  tubulin alpha-4A chain [KO:K07374]
112867249  TUBA8; tubulin alpha-8 chain [KO:K07374]
112867334  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
112868247  TUBB6; tubulin beta-6 chain [KO:K07375]
112868868  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
112857201  TUBB3; tubulin beta-3 chain [KO:K07375]
112853398  tubulin beta-2 chain-like [KO:K07375]
112853544  tubulin beta-2A chain [KO:K07375]
112853548  TUBB; tubulin beta chain isoform X1 [KO:K07375]
112860891  TUBB4B; tubulin beta-4B chain [KO:K07375]
112869289  DCTN1; dynactin subunit 1 [KO:K04648]
112863774  DCTN2; dynactin subunit 2 [KO:K10424]
112865437  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
112861232  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
112853231  DCTN5; dynactin subunit 5 [KO:K10427]
112869895  DCTN6; dynactin subunit 6 [KO:K10428]
112868815  ACTR1B; beta-centractin [KO:K16575]
112854614  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
112855785  ACTR10; actin-related protein 10 [KO:K16576]
112854009  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
112868919  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
112862821  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
112863172  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
112857037  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
112870143  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
112852472  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
112852487  DNAH12; LOW QUALITY PROTEIN: dynein heavy chain 12, axonemal [KO:K10408]
112853128  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
112866355  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
112866599  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
112860415  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
112863151  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
112855026  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
112864483  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
112855822  DNAL1; dynein light chain 1, axonemal [KO:K10411]
112863842  DNAL4; dynein light chain 4, axonemal [KO:K10412]
112866144  SLC1A2; excitatory amino acid transporter 2 [KO:K05613]
112855216  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
112861192  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
112858348  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
112853155  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
112867262  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112869874  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
112860903  NRG2; LOW QUALITY PROTEIN: pro-neuregulin-2, membrane-bound isoform [KO:K05456]
112854369  NRG3; pro-neuregulin-3, membrane-bound isoform [KO:K05457]
112855508  NRG4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
112866849  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
pcoo00190  Oxidative phosphorylation
pcoo03013  Nucleocytoplasmic transport
pcoo03050  Proteasome
pcoo04010  MAPK signaling pathway
pcoo04012  ErbB signaling pathway
pcoo04020  Calcium signaling pathway
pcoo04115  p53 signaling pathway
pcoo04137  Mitophagy - animal
pcoo04140  Autophagy - animal
pcoo04141  Protein processing in endoplasmic reticulum
pcoo04210  Apoptosis
pcoo04724  Glutamatergic synapse
pcoo04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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