KEGG   PATHWAY: plop04510
Entry
plop04510                   Pathway                                
Name
Focal adhesion - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
plop04510  Focal adhesion
plop04510

Other DBs
GO: 0005925
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125347013  Col1a2; collagen alpha-2(I) chain [KO:K06236]
125365631  Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
125354877  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
125348106  Col4a1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
125348107  Col4a2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
125350237  Col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
125350238  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
125343870  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
125344255  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125342346  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
125350154  Col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
125351377  Col6a2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
125351379  Col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
125344999  collagen alpha-1(VI) chain [KO:K06238]
125353783  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
125354978  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
125357626  Col9a1; collagen alpha-1(IX) chain [KO:K08131]
125357277  Lama2; laminin subunit alpha-2 [KO:K05637]
125364133  Lama1; laminin subunit alpha-1 [KO:K05637]
125353773  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
125363903  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
125357195  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
125346879  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
125342554  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
125359631  Lamb3; laminin subunit beta-3 isoform X1 [KO:K06244]
125346878  Lamb4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
125360004  Lamc1; laminin subunit gamma-1 [KO:K05635]
125359512  Lamc2; laminin subunit gamma-2 [KO:K06246]
125353209  Lamc3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
125365545  Chad; chondroadherin [KO:K06248]
125346913  Reln; reelin [KO:K06249] [EC:3.4.21.-]
125340576  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
125339848  Thbs4; thrombospondin-4 [KO:K04659]
125348933  cartilage oligomeric matrix protein [KO:K04659]
125357497  Thbs2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
125344998  thrombospondin-2 [KO:K04659]
125359140  Thbs3; thrombospondin-3 [KO:K04659]
125350332  Fn1; fibronectin isoform X1 [KO:K05717]
125364494  Spp1; osteopontin [KO:K06250]
125365546  Vtn; vitronectin [KO:K06251]
125347252  Tnc; tenascin isoform X1 [KO:K06252]
125359257  Tnr; tenascin-R isoform X1 [KO:K06252]
125352745  Tnxb; tenascin-X [KO:K06252]
125360095  Tnn; tenascin-N isoform X1 [KO:K06252]
125364844  bone sialoprotein 2 [KO:K06253]
125367498  Itga1; integrin alpha-1 [KO:K06480]
125367487  Itga2; integrin alpha-2 [KO:K06481]
125365988  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
125365969  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
125350497  Itga4; integrin alpha-4 [KO:K06483]
125363601  Itga5; integrin alpha-5 [KO:K06484]
125350555  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
125363375  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
125366767  Itga8; integrin alpha-8 [KO:K06584]
125342437  Itga9; integrin alpha-9 [KO:K06585]
125355511  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
125338720  Itga11; integrin alpha-11 [KO:K06587]
125350485  Itgav; integrin alpha-V [KO:K06487]
125366727  Itgb1; integrin beta-1 [KO:K05719]
125366291  Itgb3; integrin beta-3 [KO:K06493]
125365686  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
125351789  Itgb5; integrin beta-5 [KO:K06588]
125350628  Itgb6; integrin beta-6 [KO:K06589]
125364132  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
125346836  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
125340767  Emp2; epithelial membrane protein 2 [KO:K26256]
125339510  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125358224  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
125349532  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125364930  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
125341585  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
125359379  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125352543  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
125361173  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
125363322  Pgf; placenta growth factor isoform X1 [KO:K16859]
125339553  Vegfc; vascular endothelial growth factor C [KO:K05449]
125343391  Vegfd; vascular endothelial growth factor D [KO:K05449]
125346953  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
125364960  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125339985  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125368530  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125364405  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125346757  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125348386  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125344151  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
125342051  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125347055  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125365164  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
125353459  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
125338763  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
125363640  Arhgap5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
125367464  transforming protein RhoA-like [KO:K04513]
125347858  transforming protein RhoA-like [KO:K04513]
125342586  Rhoa; transforming protein RhoA [KO:K04513]
125339772  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
125364223  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
125356729  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
125347983  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
125364763  Myl5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
125345506  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
125353445  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
125355076  Myl10; myosin regulatory light chain 10 [KO:K12756]
125364186  myosin regulatory light polypeptide 9 [KO:K12757]
125364187  myosin regulatory light chain 12B [KO:K12757]
125340270  Myl11; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
125361327  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
125349126  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
125356603  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125345760  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
125360886  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
125359475  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
125339077  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
125353356  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
125358504  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
125351779  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
125353059  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
125340951  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
125348631  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
125359078  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
125338866  Actb; actin, cytoplasmic 1 [KO:K05692]
125339041  actin, cytoplasmic 1-like [KO:K05692]
125353241  actin, cytoplasmic 2-like [KO:K05692]
125350357  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
125338676  actin, cytoplasmic 1-like [KO:K05692]
125366560  Actg1; actin, cytoplasmic 2 [KO:K05692]
125338661  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
125360104  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
125339037  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
125362857  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
125339566  Tln1; talin-1 isoform X1 [KO:K06271]
125340800  Tln2; talin-2 [KO:K06271]
125343285  Flna; filamin-A isoform X1 [KO:K04437]
125358682  Flnb; filamin-B isoform X1 [KO:K27392]
125349059  Pxn; paxillin isoform X1 [KO:K05760]
125361364  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
125347267  Zyx; zyxin [KO:K06273]
125338555  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
125346479  Vcl; vinculin isoform X1 [KO:K05700]
125347007  Parvg; gamma-parvin [KO:K06275]
125362131  Parva; alpha-parvin [KO:K06275]
125341041  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125338979  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125363440  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
125363452  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125359645  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125351736  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125342497  Ctnnb1; catenin beta-1 [KO:K02105]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125340531  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125338673  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125360764  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125354550  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125342393  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125351954  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125367817  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125355095  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125348916  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125343908  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125353297  guanine nucleotide exchange factor VAV2-like [KO:K05730]
125348550  Vav1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
125364118  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
125350896  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
125343037  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125366701  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125353732  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125365137  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
125362735  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
125351829  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
125343376  Pak3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
125368462  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
125352322  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
125340766  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
125354689  Cdc42; cell division control protein 42 homolog [KO:K04393]
125345861  cell division control protein 42 homolog [KO:K04393]
125358177  Bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
125349344  Crkl; crk-like protein [KO:K04438]
125365521  Crk; adapter molecule crk isoform X1 [KO:K04438]
125345944  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
125350572  Rapgef1; rap guanine nucleotide exchange factor 1 [KO:K06277]
125355399  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
125361483  Rap1b; ras-related protein Rap-1b [KO:K07836]
125345750  ras-related protein Rap-1b-like [KO:K07836]
125346549  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125341845  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125364712  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125355221  Jun; transcription factor Jun [KO:K04448]
125347225  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125347053  Cav1; caveolin-1 isoform X1 [KO:K06278]
125347054  Cav2; caveolin-2 [KO:K12958]
125358120  Cav3; caveolin-3 [KO:K12959]
125357194  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
125360001  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
125347922  Shc2; SHC-transforming protein 2 [KO:K17447]
125355540  Shc3; SHC-transforming protein 3 [KO:K17448]
125340436  Shc4; SHC-transforming protein 4 [KO:K17449]
125365698  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
125356532  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125363420  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125358819  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125340362  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125343348  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
125362637  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125352590  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125349685  Birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
125343374  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
125362685  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
125363906  Bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
plop04010  MAPK signaling pathway
plop04060  Cytokine-cytokine receptor interaction
plop04070  Phosphatidylinositol signaling system
plop04110  Cell cycle
plop04151  PI3K-Akt signaling pathway
plop04310  Wnt signaling pathway
plop04512  ECM-receptor interaction
plop04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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