KEGG   PATHWAY: ppad04510
Entry
ppad04510                   Pathway                                
Name
Focal adhesion - Panthera pardus (leopard)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ppad04510  Focal adhesion
ppad04510

Other DBs
GO: 0005925
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109263702  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
109247299  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
109249029  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
109264962  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
109264069  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
109253654  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
109253658  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109263959  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109264961  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
109258089  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
109258106  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109264846  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
109258923  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
109258949  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
109258972  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
109248201  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
109253350  collagen alpha-3(IX) chain [KO:K08131]
109254858  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
109260619  laminin subunit alpha-2 [KO:K05637]
109248611  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
109276486  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
109253358  LAMA5; laminin subunit alpha-5 [KO:K06240]
109263563  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
109268056  LAMB1; laminin subunit beta-1 [KO:K05636]
109247785  LAMB2; laminin subunit beta-2 [KO:K06243]
109255133  LAMB3; laminin subunit beta-3 [KO:K06244]
109268053  LAMB4; laminin subunit beta-4 [KO:K06245]
109253964  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
109253935  LAMC2; laminin subunit gamma-2 [KO:K06246]
109249948  LAMC3; laminin subunit gamma-3 [KO:K06247]
109247288  CHAD; chondroadherin [KO:K06248]
109268114  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
109263182  THBS1; thrombospondin-1 [KO:K16857]
109274929  THBS4; thrombospondin-4 [KO:K04659]
109247641  COMP; cartilage oligomeric matrix protein [KO:K04659]
109245441  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
109256247  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
109265107  FN1; fibronectin isoform X1 [KO:K05717]
109276169  SPP1; osteopontin isoform X1 [KO:K06250]
109261967  osteopontin [KO:K06250]
109251863  VTN; vitronectin [KO:K06251]
109269912  TNC; tenascin isoform X1 [KO:K06252]
109260500  TNXB; tenascin-X isoform X1 [KO:K06252]
109252955  TNN; tenascin-N isoform X1 [KO:K06252]
109253015  TNR; tenascin-R [KO:K06252]
109276146  VWF; von Willebrand factor [KO:K03900]
109276234  IBSP; bone sialoprotein 2 [KO:K06253]
109275894  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
109275896  ITGA2; integrin alpha-2 [KO:K06481]
109258195  ITGA2B; integrin alpha-IIb [KO:K06476]
109247309  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
109273952  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109249251  ITGA5; integrin alpha-5 [KO:K06484]
109273006  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109270291  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109273690  ITGA8; integrin alpha-8 [KO:K06584]
109248733  ITGA9; integrin alpha-9 [KO:K06585]
109259168  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109262786  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
109274234  ITGAV; integrin alpha-V [KO:K06487]
109276308  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109276923  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109266512  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109271789  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109249190  ITGB7; integrin beta-7 [KO:K06590]
109263803  ITGB8; integrin beta-8 [KO:K06591]
109278309  EMP2; epithelial membrane protein 2 [KO:K26256]
109251089  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109265580  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109262483  PDGFC; platelet-derived growth factor C [KO:K05450]
109257520  PDGFD; platelet-derived growth factor D [KO:K05450]
109248153  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
109265419  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109271390  VEGFA; vascular endothelial growth factor A [KO:K05448]
109246982  VEGFB; vascular endothelial growth factor B [KO:K16858]
109253846  PGF; placenta growth factor isoform X1 [KO:K16859]
109248315  VEGFD; vascular endothelial growth factor D [KO:K05449]
109257848  VEGFC; vascular endothelial growth factor C [KO:K05449]
109268152  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109278988  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109275948  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109273360  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109278955  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109267979  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109266122  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109278978  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109248389  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
109247423  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109268636  EMP1; epithelial membrane protein 1 [KO:K26255]
109272472  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109253182  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
109254302  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
109247805  RHOA; transforming protein RhoA [KO:K04513]
109252200  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
109248559  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109268495  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109277655  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109259322  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
109267914  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
109272490  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
109250506  MYL10; myosin regulatory light chain 10 [KO:K12756]
109248585  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
109248586  myosin regulatory light chain 12B [KO:K12757]
109258960  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
109258998  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109266491  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109246846  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109277658  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109270552  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109256388  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
109259902  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
109249481  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
109266499  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109270987  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109272590  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109275437  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
109255916  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109256994  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
109276785  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109251167  ACTB; actin, cytoplasmic 1 [KO:K05692]
109273575  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
109258888  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
109268265  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
109256593  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
109270161  TLN1; talin-1 isoform X1 [KO:K06271]
109262894  TLN2; talin-2 [KO:K06271]
109259850  FLNA; filamin-A [KO:K04437]
109279138  FLNB; filamin-B [KO:K27392]
109277539  PXN; paxillin isoform X1 [KO:K05760]
109261635  integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
109271076  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
109269180  ZYX; zyxin [KO:K06273]
109253231  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
109264429  VCL; vinculin isoform X1 [KO:K05700]
109265693  PARVG; gamma-parvin isoform X1 [KO:K06275]
109265694  PARVB; beta-parvin isoform X1 [KO:K06275]
109271150  PARVA; alpha-parvin isoform X1 [KO:K06275]
109278175  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
109256570  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109251379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109257810  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109266441  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109248805  CTNNB1; catenin beta-1 [KO:K02105]
109277056  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109255537  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109259277  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
109273067  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109274075  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109275159  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109259912  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109266953  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109275060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109247606  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109255395  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109258267  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109271959  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
109261030  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
109251192  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109265228  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109277132  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109267249  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109266552  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109253672  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
109256627  serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
109274718  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
109263168  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
109274276  CDC42; cell division control protein 42 homolog [KO:K04393]
109245694  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
109259695  CRKL; crk-like protein [KO:K04438]
109255155  CRK; adapter molecule crk isoform X1 [KO:K04438]
109252245  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109249998  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
109272045  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109259557  ras-related protein Rap-1b [KO:K07836]
109270479  RAP1B; ras-related protein Rap-1b [KO:K07836]
109278973  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109276314  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109264550  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109266785  JUN; transcription factor AP-1 [KO:K04448]
109269114  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109248391  CAV1; caveolin-1 isoform X1 [KO:K06278]
109248392  CAV2; caveolin-2 isoform X1 [KO:K12958]
109254405  CAV3; caveolin-3 [KO:K12959]
109263555  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
109256269  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
109257730  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
109275536  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
109263016  SHC4; SHC-transforming protein 4 [KO:K17449]
109276940  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
109268505  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
109265500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109259759  GTPase HRas [KO:K02833]
109257492  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109262816  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109259699  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109261343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109248161  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
109246902  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109276198  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109271613  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109257521  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
109257526  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109250719  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
109246663  BAD; bcl2-associated agonist of cell death [KO:K02158]
109275625  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
ppad04010  MAPK signaling pathway
ppad04060  Cytokine-cytokine receptor interaction
ppad04070  Phosphatidylinositol signaling system
ppad04110  Cell cycle
ppad04151  PI3K-Akt signaling pathway
ppad04310  Wnt signaling pathway
ppad04512  ECM-receptor interaction
ppad04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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