KEGG   PATHWAY: psiu04151
Entry
psiu04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Phocoena sinus (vaquita)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
psiu04151  PI3K-Akt signaling pathway
psiu04151

Other DBs
GO: 0043491
Organism
Phocoena sinus (vaquita) [GN:psiu]
Gene
116754608  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116764662  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
116754675  EREG; proepiregulin [KO:K09784]
116754393  AREG; amphiregulin [KO:K09782]
116751451  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116753904  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
116758288  LOW QUALITY PROTEIN: fibroblast growth factor 2-like [KO:K18497]
116746806  FGF20; fibroblast growth factor 20 [KO:K04358]
116754298  FGF5; fibroblast growth factor 5 [KO:K04358]
116760979  FGF6; fibroblast growth factor 6 [KO:K04358]
116747847  FGF16; fibroblast growth factor 16 [KO:K04358]
116755801  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116749192  FGF7; fibroblast growth factor 7 [KO:K04358]
116750440  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116750545  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
116757391  FGF4; fibroblast growth factor 4 [KO:K04358]
116757392  FGF3; fibroblast growth factor 3 [KO:K04358]
116741677  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116751461  FGF10; fibroblast growth factor 10 [KO:K04358]
116758422  FGF19; fibroblast growth factor 19 [KO:K22603]
116744336  FGF21; fibroblast growth factor 21 [KO:K22429]
116761246  FGF23; fibroblast growth factor 23 [KO:K22428]
116754467  NGF; beta-nerve growth factor [KO:K02582]
116758559  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116760719  NTF3; neurotrophin-3 [KO:K04356]
116744343  NTF4; neurotrophin-4 [KO:K12457]
116758168  insulin [KO:K04526]
116760902  IGF1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
116758167  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
116740378  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116761017  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116754109  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
116758674  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116756768  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116760722  KITLG; kit ligand isoform X1 [KO:K05461]
116743695  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116762165  VEGFA; vascular endothelial growth factor A [KO:K05448]
116758090  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116749646  PGF; placenta growth factor isoform X1 [KO:K16859]
116746676  VEGFC; vascular endothelial growth factor C [KO:K05449]
116747916  VEGFD; vascular endothelial growth factor D [KO:K05449]
116759711  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
116742473  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
116746760  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116740279  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
116744243  EFNA3; ephrin-A3 [KO:K05462]
116744249  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
116738713  EFNA1; ephrin-A1 [KO:K05462]
116752074  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
116752293  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
116751822  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
116751991  NRTN; neurturin [KO:K25414]
116760139  ARTN; artemin [KO:K25415]
116752001  PSPN; persephin [KO:K25416]
116759758  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
116745518  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
116761086  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116756965  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
116746732  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
116741579  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116754486  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116751966  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116745757  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116756746  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
116755336  NTRK2; LOW QUALITY PROTEIN: BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
116751331  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116748753  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116754045  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116751332  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116752024  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116754507  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116743304  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
116742893  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116752252  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116754436  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116759279  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116755617  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116756797  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116742042  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116746378  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116747062  SOS2; son of sevenless homolog 2 [KO:K03099]
116764289  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116757893  HRAS; GTPase HRas isoform X1 [KO:K02833]
116751649  uncharacterized protein LOC116751649 [KO:K02833]
116760326  KRAS; GTPase KRas isoform X1 [KO:K07827]
116739088  NRAS; GTPase NRas [KO:K07828]
116761625  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116747589  MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116751189  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116738910  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116740620  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
116756739  IRS1; insulin receptor substrate 1 [KO:K16172]
116754202  TLR2; toll-like receptor 2 [KO:K10159]
116755398  TLR4; toll-like receptor 4 [KO:K10160]
116761737  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116739565  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116755719  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
116740545  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
116741393  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
116745532  somatotropin [KO:K05438]
116762705  PRL; prolactin isoform X1 [KO:K05439]
116739070  OSM; oncostatin-M [KO:K05418]
116754231  IL2; interleukin-2 [KO:K05429]
116751037  interleukin-3-like [KO:K04736]
116759822  IL6; interleukin-6 isoform X1 [KO:K05405]
116751393  IL4; interleukin-4 [KO:K05430]
116742373  IL7; interleukin-7 isoform X1 [KO:K05431]
116755247  interferon alpha-1-like [KO:K05414]
116755466  interferon alpha-1-like [KO:K05414]
116755467  interferon alpha-1-like [KO:K05414]
116756115  interferon alpha-1-like [KO:K05414]
116755914  IFNB1; interferon beta [KO:K05415]
116740523  EPO; erythropoietin [KO:K05437]
116745666  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
116751870  GHR; growth hormone receptor isoform X1 [KO:K05080]
116751896  PRLR; prolactin receptor isoform X1 [KO:K05081]
116750938  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
116748786  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
116760998  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
116747462  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
116746994  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
116748787  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
116740907  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
116751594  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
116752564  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116752781  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
116751362  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
116744796  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
116756336  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
116755422  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
116751653  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
116759245  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
116745191  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
116760999  COL2A1; collagen alpha-1(II) chain [KO:K19719]
116747864  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
116748067  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116756400  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
116756805  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116743163  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
116743164  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
116753029  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
116753030  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
116753075  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
116756922  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
116752834  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
116743487  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
116739831  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
116763458  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
116763252  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
116765008  LAMA1; laminin subunit alpha-1 [KO:K05637]
116739717  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
116765156  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
116763363  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
116759601  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
116761805  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
116741523  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
116750559  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
116756094  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
116756082  LAMC3; laminin subunit gamma-3 [KO:K06247]
116745178  CHAD; chondroadherin [KO:K06248]
116759789  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116748587  THBS1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
116749562  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
116763676  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
116751864  COMP; cartilage oligomeric matrix protein [KO:K04659]
116752206  THBS4; thrombospondin-4 [KO:K04659]
116756945  FN1; fibronectin isoform X1 [KO:K05717]
116754469  SPP1; osteopontin [KO:K06250]
116745287  VTN; vitronectin [KO:K06251]
116760986  TNR; tenascin-R [KO:K06252]
116755484  TNC; tenascin isoform X1 [KO:K06252]
116762928  TNXB; tenascin-X isoform X1 [KO:K06252]
116764929  TNN; tenascin-N [KO:K06252]
116760832  VWF; von Willebrand factor isoform X1 [KO:K03900]
116754579  IBSP; bone sialoprotein 2 [KO:K06253]
116750743  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
116750842  ITGA2; integrin alpha-2 [KO:K06481]
116746301  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
116745368  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
116756296  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
116760042  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
116756709  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
116760594  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
116749001  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
116762719  ITGA9; integrin alpha-9 [KO:K06585]
116745510  ITGA10; integrin alpha-10 [KO:K06586]
116748382  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
116757071  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
116748884  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
116746035  ITGB3; integrin beta-3 [KO:K06493]
116746323  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
116752555  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
116757047  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
116760356  ITGB7; integrin beta-7 [KO:K06590]
116759316  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
116742653  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
116752953  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116752990  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116751286  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116750604  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116742613  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
116751944  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116751838  F2R; proteinase-activated receptor 1 [KO:K03914]
116758068  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116759002  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116756161  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
116750439  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
116739667  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
116747722  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
116761044  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
116743056  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
116764574  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116739605  GNB2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
116760197  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
116753308  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
116748817  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
116748861  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
116758798  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116742043  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116753058  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116763781  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
116743126  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
116752047  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116743417  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116744006  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
116755457  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116759883  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X1 [KO:K04546]
116756875  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116740969  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116759589  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116745853  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116759199  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
116746412  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
116745258  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
116739722  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
116750705  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
116739822  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
116751414  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116742040  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
116755497  TSC1; hamartin isoform X1 [KO:K07206]
116740928  TSC2; tuberin isoform X1 [KO:K07207]
116759598  RHEB; GTP-binding protein Rheb [KO:K07208]
116740632  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
116751184  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116745714  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
116746768  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
116754404  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
116756589  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
116750994  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
116743168  eukaryotic translation initiation factor 4E-like [KO:K03259]
116745009  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116760384  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
116755272  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
116755897  40S ribosomal protein S6-like [KO:K02991]
116763320  40S ribosomal protein S6-like [KO:K02991]
116758256  40S ribosomal protein S6-like [KO:K02991]
116741887  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
116745476  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116751232  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
116749748  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
116755096  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
116763384  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
116759483  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
116740998  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
116742526  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
116743673  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116759669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116748950  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116762017  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116759043  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
116741761  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116739888  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
116746674  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116750919  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116743774  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
116757415  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
116746197  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
116754762  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
116755706  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
116741434  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
116752026  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
116753268  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
116747993  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
116748480  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
116746995  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
116761517  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
116748702  PPP2R5E; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
116751199  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
116758459  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
116761650  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
116749262  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
116750427  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
116760340  HSP90B1; LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
116751906  CDC37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
116757632  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
116744245  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
116738932  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1 [KO:K16340] [EC:3.1.3.16]
116748663  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
116748662  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
116747843  MTCP1; protein p13 MTCP-1 [KO:K16837]
116759107  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
116745065  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
116752844  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116744253  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
116760633  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
116749461  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
116740888  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
116746427  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
116739361  glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
116756289  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
116745075  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
116742545  MYC; myc proto-oncogene protein [KO:K04377]
116757387  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116762584  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116760537  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116760157  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116760381  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
116759522  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
116760293  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
116762780  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116744703  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
116742324  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116763183  FOXO3; forkhead box protein O3 [KO:K09408]
116743728  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
116739025  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116764419  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
116760120  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
116754678  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
116740099  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
116764225  YWHAQ; 14-3-3 protein theta isoform X1 [KO:K16197]
116742171  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
116751721  14-3-3 protein beta/alpha-like [KO:K16197]
116745690  14-3-3 protein theta-like [KO:K16197]
116745257  YWHAE; 14-3-3 protein epsilon [KO:K06630]
116753144  LOW QUALITY PROTEIN: 14-3-3 protein gamma-like [KO:K16198]
116738823  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
116740301  YWHAG; 14-3-3 protein gamma [KO:K16198]
116758242  BAD; bcl2-associated agonist of cell death [KO:K02158]
116739841  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
116738931  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
116757481  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116756730  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
116756632  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
116761029  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
116755320  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116740243  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116758621  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
116751955  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
116759300  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
116759616  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
116762930  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
116760285  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
116755213  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116760487  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
116747398  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116741676  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116746707  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116758150  RELA; transcription factor p65 isoform X1 [KO:K04735]
116754222  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116763738  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
116760130  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
116745739  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
psiu00010  Glycolysis / Gluconeogenesis
psiu04010  MAPK signaling pathway
psiu04012  ErbB signaling pathway
psiu04062  Chemokine signaling pathway
psiu04064  NF-kappa B signaling pathway
psiu04068  FoxO signaling pathway
psiu04110  Cell cycle
psiu04115  p53 signaling pathway
psiu04150  mTOR signaling pathway
psiu04210  Apoptosis
psiu04370  VEGF signaling pathway
psiu04510  Focal adhesion
psiu04620  Toll-like receptor signaling pathway
psiu04630  JAK-STAT signaling pathway
psiu04662  B cell receptor signaling pathway
psiu04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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