KEGG   PATHWAY: pteh04510
Entry
pteh04510                   Pathway                                
Name
Focal adhesion - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pteh04510  Focal adhesion
pteh04510

Other DBs
GO: 0005925
Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111552480  COL1A2; collagen alpha-2(I) chain [KO:K06236]
111537568  COL1A1; collagen alpha-1(I) chain [KO:K06236]
111555277  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
111536673  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
111546314  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
111546316  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
111527511  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
111527529  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
111536655  collagen alpha-6(IV) chain-like [KO:K06237]
111539443  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
111553748  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111527942  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111527947  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
111539442  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
111539510  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
111520484  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111554646  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
111548837  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
111554928  LAMA2; laminin subunit alpha-2 [KO:K05637]
111553579  LAMA1; laminin subunit alpha-1 [KO:K05637]
111520480  laminin subunit alpha-5 [KO:K06240]
111539764  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
111547317  LAMA4; laminin subunit alpha-4 [KO:K06241]
111520373  LAMB1; laminin subunit beta-1 [KO:K05636]
111555391  LAMB2; laminin subunit beta-2 [KO:K06243]
111531101  LAMB3; laminin subunit beta-3 [KO:K06244]
111520401  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
111536950  LAMC1; laminin subunit gamma-1 [KO:K05635]
111536949  LAMC2; laminin subunit gamma-2 [KO:K06246]
111545964  LAMC3; laminin subunit gamma-3 [KO:K06247]
111537574  CHAD; chondroadherin [KO:K06248]
111526701  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111524230  THBS1; thrombospondin-1 [KO:K16857]
111530915  THBS2; thrombospondin-2 [KO:K04659]
111544433  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
111554211  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
111548154  FN1; fibronectin isoform X1 [KO:K05717]
111530883  SPP1; osteopontin isoform X1 [KO:K06250]
111520771  VTN; vitronectin isoform X1 [KO:K06251]
111550356  TNC; tenascin isoform X1 [KO:K06252]
111528966  TNXB; tenascin-X [KO:K06252]
111539366  TNR; tenascin-R isoform X1 [KO:K06252]
111539367  TNN; tenascin-N [KO:K06252]
111555950  VWF; von Willebrand factor [KO:K03900]
111530880  IBSP; bone sialoprotein 2 [KO:K06253]
111541654  ITGA1; integrin alpha-1 [KO:K06480]
111541653  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
111525821  ITGA2B; integrin alpha-IIb [KO:K06476]
111537562  ITGA3; integrin alpha-3 [KO:K06482]
111542790  ITGA4; integrin alpha-4 [KO:K06483]
111541902  ITGA5; integrin alpha-5 [KO:K06484]
111522158  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111541886  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
111550012  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
111523197  ITGA9; integrin alpha-9 [KO:K06585]
111531387  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
111548412  ITGA11; integrin alpha-11 [KO:K06587]
111542813  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111546659  ITGB1; integrin beta-1 [KO:K05719]
111526557  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111542414  ITGB4; integrin beta-4 [KO:K06525]
111544514  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
111546158  ITGB6; integrin beta-6 [KO:K06589]
111541940  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
111545093  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
111555232  EMP2; epithelial membrane protein 2 [KO:K26256]
111523727  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111549133  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111553384  PDGFC; platelet-derived growth factor C [KO:K05450]
111540080  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
111547933  EGF; pro-epidermal growth factor [KO:K04357]
111523785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
111543089  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111522374  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
111520971  PGF; placenta growth factor isoform X1 [KO:K16859]
111531650  VEGFD; vascular endothelial growth factor D [KO:K05449]
111554086  VEGFC; vascular endothelial growth factor C [KO:K05449]
111552446  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
111520430  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111552670  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111548389  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111526494  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111555709  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111540453  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
111527329  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
111553422  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111537465  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111552044  EMP1; epithelial membrane protein 1 [KO:K26255]
111553268  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111519926  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
111552899  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
111555593  RHOA; transforming protein RhoA [KO:K04513]
111526967  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
111553507  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111532006  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
111539037  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
111552271  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
111548199  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
111536834  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K12756]
111547935  uncharacterized protein LOC111547935 [KO:K12756]
111527906  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
111553582  MYL12B; myosin regulatory light chain 12B [KO:K12757]
111553583  myosin regulatory light chain 12A [KO:K12757]
111525699  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
111522255  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
111536803  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111546019  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111547177  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111522682  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
111521200  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
111524418  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
111548207  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111548560  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
111520668  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111543331  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
111543644  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
111552124  actin, cytoplasmic 2 [KO:K05692]
111530610  ACTB; actin, cytoplasmic 1 [KO:K05692]
113225257  actin, cytoplasmic 2 [KO:K05692]
111533492  actin, cytoplasmic 1 [KO:K05692]
111546247  actin, cytoplasmic 1-like [KO:K05692]
111526135  actin, cytoplasmic 2-like [KO:K05692]
111542306  ACTG1; actin, cytoplasmic 2 [KO:K05692]
111527206  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
111537094  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
111520112  ACTN1; alpha-actinin-1 [KO:K05699]
111554064  ACTN4; alpha-actinin-4 [KO:K05699]
111521745  TLN2; talin-2 [KO:K06271]
111536837  TLN1; talin-1 [KO:K06271]
111534210  FLNB; filamin-B isoform X1 [KO:K27392]
111537633  paxillin isoform X1 [KO:K05760]
111524650  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
111521549  ZYX; zyxin [KO:K06273]
111519981  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
111537836  VCL; vinculin isoform X1 [KO:K05700]
111555033  PARVA; alpha-parvin [KO:K06275]
111548913  PARVG; gamma-parvin isoform X1 [KO:K06275]
111548915  PARVB; beta-parvin isoform X1 [KO:K06275]
111554120  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111545216  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111538340  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111543871  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111555526  CTNNB1; catenin beta-1 [KO:K02105]
111542503  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111524197  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111530493  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111553372  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111521403  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111544647  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111523340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111554247  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111539891  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111548774  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111551321  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111530126  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
111523994  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111522605  VAV1; proto-oncogene vav [KO:K05730]
111530500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111549042  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111527658  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
111540806  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
111544329  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111536669  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
111554067  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
111546512  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
113219483  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
111547718  CDC42; cell division control protein 42 homolog [KO:K04393]
111536154  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111530661  CRKL; crk-like protein [KO:K04438]
111530638  CRK; adapter molecule crk isoform X1 [KO:K04438]
111550784  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
111545822  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111556041  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
111528626  RAP1B; ras-related protein Rap-1b [KO:K07836]
111532119  ras-related protein Rap-1b [KO:K07836]
111530867  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111535725  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111554538  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111523160  JUN; transcription factor AP-1 [KO:K04448]
111521522  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111553398  CAV1; caveolin-1 isoform X1 [KO:K06278]
111553423  CAV2; caveolin-2 isoform X1 [KO:K12958]
111546899  CAV3; caveolin-3 [KO:K12959]
111547323  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
111543732  SHC1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
111528883  SHC2; SHC-transforming protein 2 [KO:K17447]
111527961  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
111552722  SHC4; SHC-transforming protein 4 [KO:K17449]
111542428  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111545353  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111549528  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111546904  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111548354  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111530673  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111525729  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
111535736  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
111522272  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111535839  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111543039  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111540065  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
111540066  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
111532918  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
111522294  BAD; bcl2-associated agonist of cell death [KO:K02158]
111528437  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pteh04010  MAPK signaling pathway
pteh04060  Cytokine-cytokine receptor interaction
pteh04070  Phosphatidylinositol signaling system
pteh04110  Cell cycle
pteh04151  PI3K-Akt signaling pathway
pteh04310  Wnt signaling pathway
pteh04512  ECM-receptor interaction
pteh04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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