KEGG   PATHWAY: rro05208
Entry
rro05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
rro05208  Chemical carcinogenesis - reactive oxygen species
rro05208

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104656532  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
104662936  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
104662944  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
104662954  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
104662965  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
104656035  GSTM4; glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
104656061  glutathione S-transferase Mu 2 isoform X3 [KO:K00799] [EC:2.5.1.18]
104656071  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
104678116  GSTM5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
104662429  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
104670178  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
104680320  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
104675852  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
104668124  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
104672059  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
104667407  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
104667408  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
104667423  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
104654333  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
104656552  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
104656553  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
104667412  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
4171534  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4171535  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4171541  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4171543  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4171542  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4171544  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4171545  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
104664727  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
104670231  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
104674738  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
104678001  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
104668090  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
115898726  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
104681769  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
104681673  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
104676020  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
104682371  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
104655119  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
115898341  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
115900323  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
104663455  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
104680801  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
104666007  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
104670246  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
115897013  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
104682265  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
104655854  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
104658990  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
104660451  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X6 [KO:K03954]
104658248  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
104665386  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
104678588  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
104680657  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
104679039  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
104659699  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
104671857  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
104666513  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
104680979  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
115898156  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
115894162  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
104670533  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
104656987  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
115894594  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
104655058  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
104661038  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
104682589  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
104656478  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
104662797  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
104681527  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
104664585  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
104653602  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
104664715  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
104665340  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
104668417  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
115891979  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
104672473  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
104681936  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
104670266  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
104654148  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
104653643  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
115898976  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
115896538  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
104661530  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
104671414  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
104664718  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
104654339  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
104664308  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
104662045  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
104668708  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
104669912  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
104663917  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
104669001  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
104675621  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
104665348  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
104677354  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
104668069  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
104656160  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4171546  CYTB; cytochrome b [KO:K00412]
104671687  cytochrome c1, heme protein, mitochondrial [KO:K00413]
104667772  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
104682087  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
104662117  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
104671564  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
104659826  cytochrome b-c1 complex subunit 8 [KO:K00418]
104659363  cytochrome b-c1 complex subunit 9 isoform X2 [KO:K00419]
104671409  cytochrome b-c1 complex subunit 10 [KO:K00420]
104657632  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 10 [KO:K00420]
115897633  cytochrome b-c1 complex subunit 10 [KO:K00420]
4171540  COX3; cytochrome c oxidase subunit III [KO:K02262]
4171536  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4171537  COX2; cytochrome c oxidase subunit II [KO:K02261]
104653722  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
104656020  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
104672160  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
104661470  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
104661582  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
104666251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104670251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104660364  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104667089  cytochrome c oxidase subunit 6B1 [KO:K02267]
104682113  cytochrome c oxidase subunit 6B2 [KO:K02267]
104679876  cytochrome c oxidase subunit 6C [KO:K02268]
115894606  cytochrome c oxidase subunit 6C-like [KO:K02268]
115892804  cytochrome c oxidase subunit 6C [KO:K02268]
115893203  cytochrome c oxidase subunit 6C-like [KO:K02268]
115895267  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-like [KO:K02268]
104677541  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
104666288  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
104669287  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
104669550  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
104680071  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
104671254  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
115900678  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
104672609  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115897656  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115899665  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115899666  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115898290  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115899930  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115892348  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115898701  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115899083  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115898718  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115896572  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115896575  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115894755  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115896799  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115892928  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115897482  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115898761  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115893223  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115893945  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115896524  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115897625  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115899181  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
104672955  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
104679055  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
104680752  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
104673663  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
104682665  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
104671420  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
104663802  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
4171539  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
104658937  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
104659648  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
104672398  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
104670586  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
104659379  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
104658760  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
104678202  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
4171538  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
104666425  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
104659812  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
115894591  voltage-dependent anion-selective channel protein 1 [KO:K05862]
115895711  voltage-dependent anion-selective channel protein 1 [KO:K05862]
104671883  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
104666042  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104661254  LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
104663348  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
104673881  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
104673801  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
115899258  ADP/ATP translocase 2 [KO:K05863]
104662253  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
104664641  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
104658349  CAT; catalase [KO:K03781] [EC:1.11.1.6]
104671723  SLC26A1; sulfate anion transporter 1 [KO:K14700]
104670404  SLC26A2; sulfate transporter [KO:K14701]
104667747  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
104661727  SLC26A9; solute carrier family 26 member 9 isoform X1 [KO:K14706]
104672152  LOW QUALITY PROTEIN: cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
104680852  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
104676181  LOW QUALITY PROTEIN: cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
104672151  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
104680972  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
104660094  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
104673945  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
104661024  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
104667815  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
104662135  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
104678925  aldo-keto reductase family 1 member C1 homolog isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
104674747  aldo-keto reductase family 1 member C15 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104678924  aldo-keto reductase family 1 member C3 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104674748  aldo-keto reductase family 1 member C4 isoform X1 [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
104655880  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X2 [KO:K00355] [EC:1.6.5.2]
104680046  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
104674165  AHR; aryl hydrocarbon receptor [KO:K09093]
104667616  uncharacterized protein LOC104667616 [KO:K09093]
104669825  LPO; lactoperoxidase isoform X2 [KO:K12550] [EC:1.11.1.7]
104678914  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
104655986  cytochrome b-245 light chain [KO:K08009]
104675589  NOX1; NADPH oxidase 1 [KO:K08008]
104681251  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
104666804  NCF2; neutrophil cytosol factor 2 [KO:K08010]
104682421  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104675886  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104681576  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104682633  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104663024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104682751  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104669078  NRAS; GTPase NRas [KO:K07828]
104664593  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104675014  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
104672345  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
104679497  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
104676194  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104678447  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104668007  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104660767  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104660769  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104682867  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682868  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104664278  JUN; transcription factor AP-1 [KO:K04448]
104677590  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104661825  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104682713  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115893905  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104677475  FOXO3; forkhead box protein O3 [KO:K09408]
104673141  BAD; bcl2-associated agonist of cell death [KO:K02158]
104678520  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
104675158  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104679802  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104664815  RELA; transcription factor p65 [KO:K04735]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104672393  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
104668433  PTPRJ; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
104680237  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
104679856  low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
104674419  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
104655840  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
115895854  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
104660552  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
104672008  ABL2; tyrosine-protein kinase ABL2 isoform X4 [KO:K08887] [EC:2.7.10.2]
104669942  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
104673404  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
104671236  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
104679749  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104666985  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
104663087  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
104678377  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104655242  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
104681067  ARNT; LOW QUALITY PROTEIN: aryl hydrocarbon receptor nuclear translocator [KO:K09097]
104667362  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104670474  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
104677398  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
104682468  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
115895303  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
rro00190  Oxidative phosphorylation
rro00980  Metabolism of xenobiotics by cytochrome P450
rro04010  MAPK signaling pathway
rro04064  NF-kappa B signaling pathway
rro04066  HIF-1 signaling pathway
rro04151  PI3K-Akt signaling pathway
rro04370  VEGF signaling pathway
rro05207  Chemical carcinogenesis - receptor activation
rro05211  Renal cell carcinoma
rro05215  Prostate cancer
rro05219  Bladder cancer
rro05221  Acute myeloid leukemia
rro05222  Small cell lung cancer
rro05223  Non-small cell lung cancer
rro05224  Breast cancer
rro05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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