KEGG   PATHWAY: sbq04613
Entry
sbq04613                    Pathway                                
Name
Neutrophil extracellular trap formation - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action is the formation of neutrophil extracellular traps (NETs), the extracellular structures composed of chromatin coated with histones, proteases and granular and cytosolic proteins that help catch and kill microorganisms. NETs are formed by a process known as "NETosis" that can be triggered by microorganisms and endogenous stimuli, such as damage-associated molecular patterns and immune complexes, and involves activation in most cases of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, which produces reactive oxygen species (ROS). Recent study has reported that there are two different mechanisms of NETosis, including a lytic NETosis and a vital NETosis. Lytic NETosis begins with nuclear delobulation and the disassembly of the nuclear envelope and continues with loss of cellular polarization, chromatin decondensation and plasma membrane rupture. Vital NETosis can occur independently of cell death and involves the secreted expulsion of nuclear chromatin that is accompanied by the release of granule proteins through degranulation.
Class
Organismal Systems; Immune system
Pathway map
sbq04613  Neutrophil extracellular trap formation
sbq04613

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101040447  low affinity immunoglobulin gamma Fc region receptor III isoform X2 [KO:K06463]
101031617  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101045636  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101052306  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101054407  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
101045425  cytochrome b-245 light chain [KO:K08009]
101034817  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101034334  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101029481  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101035195  TLR7; toll-like receptor 7 [KO:K05404]
101035511  TLR8; toll-like receptor 8 [KO:K10170]
101030517  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
101046117  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
101037287  ACTB; actin, cytoplasmic 1 [KO:K05692]
101050060  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
101049910  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104651678  actin, cytoplasmic 1-like [KO:K05692]
101031406  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104649961  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101038914  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101045138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101034520  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101037746  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
101030497  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
101048239  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
101039411  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101043018  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
101036833  ADP/ATP translocase 3 [KO:K05863]
101032370  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101043022  PADI4; protein-arginine deiminase type-4 [KO:K24669] [EC:3.5.3.15]
101040997  LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing protein 7 [KO:K06856]
101054381  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
101033685  uncharacterized protein LOC101033685 [KO:K06856]
101041646  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
101027415  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
101040113  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
101035688  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101053620  ITGB2; integrin beta-2 [KO:K06464]
101049788  ITGAL; integrin alpha-L [KO:K05718]
101043670  CLEC7A; C-type lectin domain family 7 member A isoform X2 [KO:K10074]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101046851  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101047168  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101052271  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101029401  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101046976  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101030999  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101030411  ATG7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
101040239  FPR3; N-formyl peptide receptor 3 [KO:K04173]
101040875  FPR2; N-formyl peptide receptor 2 [KO:K04173]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101035406  RELA; transcription factor p65 [KO:K04735]
101044671  C3; complement C3 [KO:K03990]
104651759  CR1L; complement component receptor 1-like protein isoform X1 [KO:K04011]
101048758  CR1; complement receptor type 1 [KO:K04011]
101040214  C5; complement C5 [KO:K03994]
101034910  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
101039324  LOW QUALITY PROTEIN: high mobility group protein B1-like [KO:K10802]
101045472  TLR2; toll-like receptor 2 [KO:K10159]
101043935  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101031876  ITGA2B; integrin alpha-IIb [KO:K06476]
101049562  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
101043642  FGA; LOW QUALITY PROTEIN: fibrinogen alpha chain [KO:K03903]
101043955  FGB; fibrinogen beta chain [KO:K03904]
101043315  FGG; fibrinogen gamma chain [KO:K03905]
101033397  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
101044155  VWF; von Willebrand factor [KO:K03900]
101049034  SELP; P-selectin [KO:K06496]
101034747  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
101043104  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
101048389  caspase-4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
101048062  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
101047124  GSDMD; gasdermin-D isoform X2 [KO:K20917]
101047836  HAT1; histone acetyltransferase type B catalytic subunit isoform X1 [KO:K11303] [EC:2.3.1.48]
101053861  histone H2A.V [KO:K11251]
101044182  core histone macro-H2A.2 [KO:K11251]
101037059  uncharacterized protein LOC101037059 [KO:K11251]
101039214  histone H2A-Bbd type 2/3-like [KO:K11251]
101048953  histone H2A type 1 [KO:K11251]
104649848  histone H2A type 1-D [KO:K11251]
101052234  histone H2A type 1 [KO:K11251]
101050098  histone H2A type 1-C [KO:K11251]
101030413  histone H2A type 1-A [KO:K11251]
101052551  histone H2A type 2-B [KO:K11251]
101050376  core histone macro-H2A.1 isoform X1 [KO:K11251]
101035221  histone H2A-Bbd type 2/3-like [KO:K11251]
104650223  histone H2A-Bbd type 2/3 [KO:K11251]
104650372  histone H2A type 1-like [KO:K11251]
104650373  histone H2A type 1-H-like [KO:K11251]
101052866  histone H2A type 2-C [KO:K11251]
101052214  histone H2A type 2-A-like [KO:K11251]
101036985  histone H2A type 3 [KO:K11251]
101040049  histone H2A.J [KO:K11251]
101039271  histone H2A type 1 [KO:K11251]
101049544  histone H2AX [KO:K11251]
101027550  histone H2A type 1-H [KO:K11251]
101027857  histone H2A type 1 [KO:K11251]
101028338  uncharacterized protein LOC101028338 [KO:K11252]
101049270  histone H2B type 1-like [KO:K11252]
101048322  histone H2B type 1 [KO:K11252]
101053209  histone H2B type 1-B [KO:K11252]
101030103  histone H2B type 1 [KO:K11252]
104651261  histone H2B type 1 [KO:K11252]
101030101  histone H2B type 1-A [KO:K11252]
104651689  late histone H2B.L4 [KO:K11252]
101029773  histone H2B type 1-M-like [KO:K11252]
104649920  histone H2B type 2-E [KO:K11252]
101027728  histone H2B type 2-F [KO:K11252]
101037290  histone H2B type 3-B [KO:K11252]
101037620  histone H2B type 3-A [KO:K11252]
104650371  histone H2B type 1-H [KO:K11252]
101040570  histone H2B type 1-N [KO:K11252]
101040244  histone H2B type 1-H [KO:K11252]
101028178  histone H2B type 1-K [KO:K11252]
101028704  histone H2B type 1-J [KO:K11252]
101029570  histone H2B type W-T [KO:K11252]
101037583  histone H2B type F-M [KO:K11252]
101053501  histone H4 [KO:K11254]
101039500  histone H4 [KO:K11254]
101039577  histone H4 [KO:K11254]
101052568  LOW QUALITY PROTEIN: uncharacterized protein LOC101052568 [KO:K11253]
101053540  histone H3.3-like [KO:K11253]
101035378  H3F3B; histone H3.3 [KO:K11253]
101053968  H3F3A; histone H3.3 [KO:K11253]
101047671  histone H3.1 [KO:K11253]
101054486  histone H3.1 [KO:K11253]
101049182  histone H3.3-like [KO:K11253]
104653169  histone H3.3C-like [KO:K11253]
101036450  histone H3.3-like [KO:K11253]
101028819  uncharacterized protein LOC101028819 [KO:K11253]
101050706  histone H3.3-like [KO:K11253]
101042862  histone H3.3C-like [KO:K11253]
101053187  histone H3 [KO:K11253]
101045345  LOW QUALITY PROTEIN: histone H3-like centromeric protein CSE4 [KO:K11253]
101052860  histone H3.3-like [KO:K11253]
101033898  histone H3.3-like [KO:K11253]
101044173  histone H3.1 [KO:K11253]
104650370  histone H3.1-like [KO:K11253]
101053838  histone H3.1-like [KO:K11253]
101041477  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101039964  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101030664  HDAC3; histone deacetylase 3 isoform X2 [KO:K11404] [EC:3.5.1.98]
101048948  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
101036245  HDAC4; histone deacetylase 4 isoform X2 [KO:K11406] [EC:3.5.1.98]
101053695  HDAC6; histone deacetylase 6 isoform X2 [KO:K11407] [EC:3.5.1.98]
101043404  HDAC7; histone deacetylase 7 [KO:K11408] [EC:3.5.1.98]
101040990  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
101053160  HDAC9; histone deacetylase 9 isoform X2 [KO:K11409] [EC:3.5.1.98]
101040591  HDAC10; histone deacetylase 10 isoform X2 [KO:K18671] [EC:3.5.1.98]
101028689  HDAC11; histone deacetylase 11 isoform X1 [KO:K11418] [EC:3.5.1.98]
101049998  AZU1; azurocidin [KO:K24665]
101051891  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
101039558  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
101051450  CLCN3; H(+)/Cl(-) exchange transporter 3 [KO:K05012]
101037859  CLCN5; H(+)/Cl(-) exchange transporter 5 [KO:K05012]
101029606  CLCN4; H(+)/Cl(-) exchange transporter 4 [KO:K05012]
101040884  AQP9; aquaporin-9 [KO:K09877]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00464  Mannan
C00518  Hyaluronate
C00551  beta-D-Glucan
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05151  12-O-Tetradecanoylphorbol 13-acetate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11221  Formylmethionyl-leucyl-phenylalanine methyl ester
Reference
PMID:29543328
  Authors
Van Avondt K, Hartl D
  Title
Mechanisms and disease relevance of neutrophil extracellular trap formation.
  Journal
Eur J Clin Invest 48 Suppl 2:e12919 (2018)
DOI:10.1111/eci.12919
Reference
PMID:31518165
  Authors
Sorvillo N, Cherpokova D, Martinod K, Wagner DD
  Title
Extracellular DNA NET-Works With Dire Consequences for Health.
  Journal
Circ Res 125:470-488 (2019)
DOI:10.1161/CIRCRESAHA.119.314581
Reference
PMID:28990587
  Authors
Papayannopoulos V
  Title
Neutrophil extracellular traps in immunity and disease.
  Journal
Nat Rev Immunol 18:134-147 (2018)
DOI:10.1038/nri.2017.105
Reference
PMID:24837201
  Authors
Liu FC, Chuang YH, Tsai YF, Yu HP
  Title
Role of neutrophil extracellular traps following injury.
  Journal
Shock 41:491-8 (2014)
DOI:10.1097/SHK.0000000000000146
Reference
PMID:27570525
  Authors
Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M
  Title
New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.
  Journal
Front Immunol 7:302 (2016)
DOI:10.3389/fimmu.2016.00302
Reference
PMID:28983472
  Authors
Zawrotniak M, Bochenska O, Karkowska-Kuleta J, Seweryn-Ozog K, Aoki W, Ueda M, Kozik A, Rapala-Kozik M
  Title
Aspartic Proteases and Major Cell Wall Components in Candida albicans Trigger the Release of Neutrophil Extracellular Traps.
  Journal
Front Cell Infect Microbiol 7:414 (2017)
DOI:10.3389/fcimb.2017.00414
Reference
PMID:29382950
  Authors
Honda M, Kubes P
  Title
Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system.
  Journal
Nat Rev Gastroenterol Hepatol 15:206-221 (2018)
DOI:10.1038/nrgastro.2017.183
Reference
PMID:31416265
  Authors
Hamam HJ, Palaniyar N
  Title
Post-Translational Modifications in NETosis and NETs-Mediated Diseases.
  Journal
Biomolecules 9:E369 (2019)
DOI:10.3390/biom9080369
Reference
PMID:31767647
  Authors
Burgener SS, Schroder K
  Title
Neutrophil Extracellular Traps in Host Defense.
  Journal
Cold Spring Harb Perspect Biol 12:a037028 (2020)
DOI:10.1101/cshperspect.a037028
Reference
PMID:33202203
  Authors
Vorobjeva NV, Chernyak BV
  Title
NETosis: Molecular Mechanisms, Role in Physiology and Pathology.
  Journal
Biochemistry (Mosc) 85:1178-1190 (2020)
DOI:10.1134/S0006297920100065
Reference
PMID:31416173
  Authors
Ravindran M, Khan MA, Palaniyar N
  Title
Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology.
  Journal
Biomolecules 9:E365 (2019)
DOI:10.3390/biom9080365
Reference
PMID:28267716
  Authors
Jorch SK, Kubes P
  Title
An emerging role for neutrophil extracellular traps in noninfectious disease.
  Journal
Nat Med 23:279-287 (2017)
DOI:10.1038/nm.4294
Reference
PMID:31342866
  Authors
Goggs R, Jeffery U, LeVine DN, Li RHL
  Title
Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review.
  Journal
Vet Pathol 57:6-23 (2020)
DOI:10.1177/0300985819861721
Reference
PMID:27876233
  Authors
Kim SJ, Jenne CN
  Title
Role of platelets in neutrophil extracellular trap (NET) production and tissue injury.
  Journal
Semin Immunol 28:546-554 (2016)
DOI:10.1016/j.smim.2016.10.013
Reference
PMID:29572545
  Authors
de Bont CM, Boelens WC, Pruijn GJM
  Title
NETosis, complement, and coagulation: a triangular relationship.
  Journal
Cell Mol Immunol 16:19-27 (2019)
DOI:10.1038/s41423-018-0024-0
Reference
PMID:31129510
  Authors
Zawrotniak M, Bartnicka D, Rapala-Kozik M
  Title
UVA and UVB radiation induce the formation of neutrophil extracellular traps by human polymorphonuclear cells.
  Journal
J Photochem Photobiol B 196:111511 (2019)
DOI:10.1016/j.jphotobiol.2019.111511
Reference
PMID:21293492
  Authors
Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T
  Title
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality.
  Journal
Cell Death Differ 18:581-8 (2011)
DOI:10.1038/cdd.2011.1
Reference
PMID:23819131
  Authors
Zawrotniak M, Rapala-Kozik M
  Title
Neutrophil extracellular traps (NETs) - formation and implications.
  Journal
Acta Biochim Pol 60:277-84 (2013)
Reference
PMID:28373871
  Authors
Rosales C
  Title
Fcgamma Receptor Heterogeneity in Leukocyte Functional Responses.
  Journal
Front Immunol 8:280 (2017)
DOI:10.3389/fimmu.2017.00280
Reference
PMID:25716722
  Authors
Vorobjeva NV, Pinegin BV
  Title
Neutrophil extracellular traps: mechanisms of formation and role in health and disease.
  Journal
Biochemistry (Mosc) 79:1286-96 (2014)
DOI:10.1134/S0006297914120025
Reference
PMID:28220120
  Authors
Delgado-Rizo V, Martinez-Guzman MA, Iniguez-Gutierrez L, Garcia-Orozco A, Alvarado-Navarro A, Fafutis-Morris M
  Title
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.
  Journal
Front Immunol 8:81 (2017)
DOI:10.3389/fimmu.2017.00081
Reference
PMID:30023352
  Authors
Fonseca Z, Diaz-Godinez C, Mora N, Aleman OR, Uribe-Querol E, Carrero JC, Rosales C
  Title
Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation.
  Journal
Front Cell Infect Microbiol 8:226 (2018)
DOI:10.3389/fcimb.2018.00226
Reference
PMID:27923601
  Authors
Agraz-Cibrian JM, Giraldo DM, Mary FM, Urcuqui-Inchima S
  Title
Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity.
  Journal
Virus Res 228:124-133 (2017)
DOI:10.1016/j.virusres.2016.11.033
Reference
PMID:27698656
  Authors
Schonrich G, Raftery MJ
  Title
Neutrophil Extracellular Traps Go Viral.
  Journal
Front Immunol 7:366 (2016)
DOI:10.3389/fimmu.2016.00366
Reference
PMID:22817992
  Authors
Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
  Title
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
  Journal
Cell Host Microbe 12:109-16 (2012)
DOI:10.1016/j.chom.2012.05.015
Reference
PMID:29908538
  Authors
Kumar S, Gupta E, Kaushik S, Jyoti A
  Title
Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.
  Journal
Iran J Allergy Asthma Immunol 17:208-220 (2018)
Related
pathway
sbq04010  MAPK signaling pathway
sbq04020  Calcium signaling pathway
sbq04140  Autophagy - animal
sbq04151  PI3K-Akt signaling pathway
sbq04610  Complement and coagulation cascades
sbq04611  Platelet activation
sbq04620  Toll-like receptor signaling pathway
sbq04621  NOD-like receptor signaling pathway
sbq04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04613   
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